Recombinant Human Insulin-Like Growth Factor 2 (somatomedin A)

• Cat.No.: IGF2-5431H
• Product Overview: Recombinant humanIGF2 was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: The IGF-II geneencodes a single transcript which results in an 156 amino acid protein,including an 89 amino acid E-domain. ProIGF-II contains sites of O-linkedglycosylation. ProIGF-II is converted to mature IGF-II by sequential cleavageafter amino acids 104, 87 and 67. Differential glycosylation and cleavagewithin the E-domain can therefore result in multiple proIGF-II isoforms.
• Purity: Greater than 95% (byHPLC and N-terminal sequence analysis).
• Molecular Weight: 11.949 kDa-confirmedby Mass Spectometry.
• Endotoxin Level: Less than 0.1 EU/ug
• Biological Activity: Stimulation ofprotein synthesis in rat L6 myoblasts.
• State and appearance: Lyophilized whitepowder.
• N-terminal sequenceanalysis: 5 residues Greaterthan 95% single sequence.
• Reconstitution: Refer to Protocol1000: Handling of GroPep IGF-I, IGF-II and IGF Analogs.
• Storage: At least 2 years at2-4°C (lyophilized).
• OfficialSymbol: IGF2

Gene Information

• Gene Name: IGF2 insulin-like growth factor2 (somatomedin A) [ Homo sapiens ]
• Synonyms: IGF2; insulin-likegrowth factor 2 (somatomedin A); IGF-II; PP9974; C11orf43; FLJ22066; FLJ44734;insulin-like growth factor II;somatomedin-A; OTTHUMP00000011012; OTTHUMP00000011013; OTTHUMP00000011015;OTTHUMP00000011018; OTTHUMP00000011157; OTTHUMP00000011158;OTTHUMP00000220677; insulin-like growth factor type 2
• Gene ID: 3481
• mRNA Refseq: NM_000612
• Protein Refseq: NP_000603
• MIM: 147470
• UniProt ID: P01344
• Chromosome Location: 11p15
• Pathway: Apoptosis;Diabetes pathways; Endochondral Ossification; Hedgehog Signaling Pathway;Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-likeGrowth Factor Binding Proteins (IGFBPs)
• Function: growthfactor activity; hormone activity; insulin receptor binding; insulin-likegrowth factor receptor binding; protein binding; protein serine/threoninekinase activator activity; receptor activator activity