IGF2BP1

  • Official Full Name

    insulin-like growth factor 2 mRNA binding protein 1
  • Overview

    This gene encodes a member of the insulin-like growth factor 2 mRNA-binding protein family. The protein encoded by this gene contains four K homology domains and two RNA recognition motifs. It functions by binding to the mRNAs of certain genes, including insulin-like growth factor 2, beta-actin and beta-transducin repeat-containing protein, and regulating their translation. Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    IGF2BP1;insulin-like growth factor 2 mRNA binding protein 1;insulin-like growth factor 2 mRNA-binding protein 1;IGF II mRNA binding protein 1;IMP 1;ZBP-1;VICKZ family member 1;zipcode-binding protein 1;IGF2 mRNA-binding protein 1;IGF-II mRNA-bind

Recombinant Proteins

  • Human
  • Rhesus macaque
  • Zebrafish
  • Chicken
  • Mouse
  • Wheat Germ
  • E.coli
  • HEK293
  • Mammalian Cells
  • Insect Cells
  • Insect cells
  • In Vitro Cell Free System
  • GST
  • His
  • DDK
  • Myc
  • Non
  • Flag
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
IGF2BP1-526H Recombinant Human IGF2BP1 protein, GST-tagged Wheat Germ Human GST 1-577 a.a.
IGF2BP1-3491H Recombinant Human IGF2BP1 protein, His-tagged E.coli Human His 126-198 aa
IGF2BP1-106H Recombinant Human IGF2BP1, MYC/DDK-tagged HEK293 Human DDK&Myc
IGF2BP1-2217R Recombinant Rhesus monkey IGF2BP1 Protein, His-tagged Mammalian Cells Rhesus macaque His
IGF2BP1-4467Z Recombinant Zebrafish IGF2BP1 Mammalian Cells Zebrafish His
IGF2BP1-6628C Recombinant Chicken IGF2BP1 Mammalian Cells Chicken His
IGF2BP1-8066M Recombinant Mouse IGF2BP1 Protein Mammalian Cells Mouse His
IGF2BP1-5265HCL Recombinant Human IGF2BP1 293 Cell Lysate HEK293 Human Non
IGF2BP1-01H Recombinant Human IGF2BP1 Protein, His-tagged E.coli Human His
IGF2BP1-13HFL Recombinant Full Length Human IGF2BP1 Protein, N-Flag-tagged Insect Cells Human Flag Full L.
IGF2BP1-2038R Recombinant Rhesus Macaque IGF2BP1 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
IGF2BP1-2038R-B Recombinant Rhesus Macaque IGF2BP1 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
IGF2BP1-3991H Recombinant Human IGF2BP1 protein(1-577aa), His&Myc-tagged E.coli Human His&Myc 1-577aa
IGF2BP1-4160H Recombinant Human IGF2BP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293 Human DDK&Myc
IGF2BP1-4462M Recombinant Mouse IGF2BP1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
IGF2BP1-4462M-B Recombinant Mouse IGF2BP1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
IGF2BP1-4568HFL Recombinant Full Length Human IGF2BP1, Flag-tagged Mammalian Cells Human Flag Full L.
IGF2BP1-5321H Recombinant Human IGF2BP1 protein, His-tagged Insect cells Human His 1-577aa
IGF2BP1-624HF Recombinant Full Length Human IGF2BP1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 577 amino acids
Igf2bp1-987M Recombinant Mouse Igf2bp1 Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc

    Involved Pathway

    IGF2BP1 involved in several pathways and played different roles in them. We selected most pathways IGF2BP1 participated on our site, such as BDNF signaling pathway,Gene Expression,Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with IGF2BP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK6/MAPK4 signaling SEPT7,MAPK6,CDC42EP2,MAPK4,CDC42EP3,CDC42EP1B,CDC42EP5
    Gene Expression FAM36A,NRBP1,DNMT3L,HNRNPF,ZNF333,RRAGA,ZNF750,NR2F6A,EIF4B,ZFP143
    Signal Transduction CNR2,RGS7,IFT52,CDC73,PRDM4,WDR19,PRC1,OPN1SW1,PROKR1A,ARHGAP8
    MAPK family signaling cascades CDC42EP2,SEPT7,CDC42EP1B,MAPK4,MAPK6,CDC42EP3,CDC42EP5
    Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA IGF2BP3,IGF2BP2
    MicroRNAs in cancer RDX,WNT3A,SOCS1,CCNE2,TNXB,Casp3,MAP2K2,HMGA2,MDM4,THBS1
    BDNF signaling pathway CDH2,CDKL5,EIF2S1,GNB2L1,CNR1,SYN1,SIRPA,FRS3,MAP3K2,CSNK2A1
    Regulation of Wnt-mediated beta catenin signaling and target gene transcription CYR61,CBY1,TNIK,TCF4,KRT1,BCL9,HBP1,AES,ZCCHC12,TLE4

    Protein Function

    IGF2BP1 has several biochemical functions, for example, mRNA 3-UTR binding,mRNA 5-UTR binding,mRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IGF2BP1 itself. We selected most functions IGF2BP1 had, and list some proteins which have the same functions with IGF2BP1. You can find most of the proteins on our site.

    Function Related Protein
    mRNA 5-UTR binding MRPS11,IGF2BP3,IGF2BP2,RPS14,DDX3X,LARP1
    translation regulator activity RPS14,IGF2BP3,AIRE,RPS9,YBX2,IGF2BP2
    protein binding FLOT1,NRF1,HYAL2,LONRF3,TNNI3,MLL1,SIGLEC6,ARID5A,TMEM106C,RAB3A
    mRNA binding MRPS7,QKI,CELF3,HNRNPAB,FXR2,PTBP2,CROP,EIF4ENIF1,DOM3Z,LIN28A
    poly(A) RNA binding HIST1H4N,HNRNPD,GLRX3,SAFB2,MYEF2,FASN,EIF3I,RPL36,HIST1H4J,RBM22
    nucleotide binding SYNCRIP,DND1,ATP11A,RTCD1,PAK2A,MYEF2,NT5C1B,CKMA,PHKG1B,ABCG2D
    mRNA 3-UTR binding RBM24A,CARHSP1,ELAVL1,AUH,TARDBP,YBX2,ELAVL2,CIRBP,SECISBP2,CPEB1

    Interacting Protein

    IGF2BP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IGF2BP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IGF2BP1.

    PRKRA;HLA-B;GSK3B;ARHGDIA;CNBP;Ybx1;PSPH;ILK;IKBKE;SMYD2;LYAR;FTSJ1;PUF60;midostaurin;NS1;pre-let-7a

    Resources

    References

    • Lederer, M; Bley, N; et al. The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancer. SEMINARS IN CANCER BIOLOGY 29:3-12(2014).

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