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Official Full Name insulin-like growth factor binding protein 7
Background This gene encodes a member of the insulin-like growth factor (IGF)-binding protein (IGFBP) family. IGFBPs bind IGFs with high affinity, and regulate IGF availability in body fluids and tissues and modulate IGF binding to its receptors. This protein binds IGF-I and IGF-II with relatively low affinity, and belongs to a subfamily of low-affinity IGFBPs. It also stimulates prostacyclin production and cell adhesion. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and one variant has been associated with retinal arterial macroaneurysm (PMID:21835307). [provided by RefSeq, Dec 2011]
Synonyms IGFBP7; insulin-like growth factor binding protein 7; AGM; PSF; TAF; FSTL2; IBP-7; MAC25; IGFBP-7; RAMSVPS; IGFBP-7v; IGFBPRP1; insulin-like growth factor-binding protein 7; IGFBP-rP1; angiomodulin; IGF-binding protein 7; PGI2-stimulating factor; tumor-derived adhesion factor; prostacyclin-stimulating factor;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Mammalian Cell
    • NSO
    • Spodoptera Frugiperda
    • Tag :
    • Fc
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Igfbp7-3490M Recombinant Mouse Igfbp7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human IGFBP7-6050H Recombinant Human IGFBP7 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IGFBP7-1630H Recombinant Human IGFBP7, His-tagged NSO His
    Human IGFBP7-1694HCL Recombinant Human IGFBP7 cell lysate Human Cell N/A
    Human IGFBP7-208H Recombinant Human IGFBP7 protein E.coli N/A
    Human IGFBP7-2483H Recombinant human IGFBP7, His-tagged E.coli His
    Human IGFBP7-5054H Recombinant Human Insulin-Like Growth Factor Binding Protein 7 Human N/A
    Human IGFBP7-5165H Recombinant Human IGFBP7, Fc tagged Human Cell Fc
    Human IGFBP7-529H Recombinant Human IGFBP7 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IGFBP7-55H Recombinant Human IGFBP7 E.coli N/A
    Human IGFBP7-6957H Recombinant Human IGFBP7 protein, His-tagged HEK293 His
    Mouse Igfbp7-1786M Recombinant Mouse Igfbp7 protein, His & T7-tagged E.coli His/T7
    Mouse Igfbp7-5645M Recombinant Mouse Insulin-Like Growth Factor Binding Protein 7, His-tagged Spodoptera Frugiperda His
    Mouse Igfbp7-971M Recombinant Mouse Igfbp7 Protein, Fc-tagged HEK293 Fc
    Rat Igfbp7-1787R Recombinant Rat Igfbp7 protein, His-tagged E.coli His
    Zebrafish IGFBP7-12177Z Recombinant Zebrafish IGFBP7 Mammalian Cell His

    igfbp7 involved in several pathways and played different roles in them. We selected most pathways igfbp7 participated on our site, such as Cellular Senescence, Cellular responses to stress, Senescence and Autophagy, which may be useful for your reference. Also, other proteins which involved in the same pathway with igfbp7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cellular Senescence TNIK; TXN; HIST4H4; LMNB1; RAD50; CBX8A; EP400; MOV10; HIST2H3C; EHMT2
    Cellular responses to stress RPS19BP1; IGFBP7; ULK1A; WIPI1; LAMTOR1; ATG9A; ACD; HIF1AN; POT1A; DYNLL2A
    Senescence and Autophagy IGFBP5; IFI16; ATG7; IL24; GABARAP; IGFBP7; MAP1LC3C; ING1; FKBP8; MAP1LC3B
    Senescence-Associated Secretory Phenotype (SASP) IGFBP7

    igfbp7 has several biochemical functions, for example, insulin-like growth factor binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by igfbp7 itself. We selected most functions igfbp7 had, and list some proteins which have the same functions with igfbp7. You can find most of the proteins on our site.

    Function Related Protein
    insulin-like growth factor binding HTRA1A; IGFBP5B; IGFBP7; WISP1B; NOV; IGFBP2A; HTRA4; WISP1; HTRA1B; DEFB126
    protein binding TGFB1; VIPAS39; LUC7L2; HCST; KISS1; NFU1; EIF3M; KRT25; KDM5B; CDH23

    igfbp7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with igfbp7 here. Most of them are supplied by our site. Hope this information will be useful for your research of igfbp7.

    ST14; asnB; q81l39_bacan; dacA; glnK; clcA; hldE; RBBP8; q9r8c5_yerpe

    Rao, C; Lin, SL; et al. High Expression of IGFBP7 in Fibroblasts Induced by Colorectal Cancer Cells Is Co-Regulated by TGF-beta and Wnt Signaling in a Smad2/3-Dvl2/3-Dependent Manner. PLOS ONE 9:-(2014).
    Chugh, S; Ouzounian, M; et al. Pilot study identifying myosin heavy chain 7, desmin, insulin-like growth factor 7, and annexin A2 as circulating biomarkers of human heart failure. PROTEOMICS 13:2324-2334(2013).

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