IKBKE

  • Official Full Name

    inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon

  • Overview

    IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling;pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed;in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 (PubMed 19481526)).
  • Synonyms

    IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; IKK i; IKKE; KIAA0151; IKK-epsilon; I-kappa-B kinase epsilon; inducible IkappaB kinase; IKK-related kinase epsilon; inducible I kappa-B kinase; IKKI; IKK-E; IKK-i; MGC125294; MGC125295; MGC125297;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IKBKE-125H Active Recombinant Human IKBKE, GST-tagged Sf9 Insect Cell GST
Human IKBKE-493H Recombinant Human IKBKE Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IKBKE-2662H Recombinant Human IKBKE, GST-His Sf9 Insect Cell GST
Human IKBKE-14133H Recombinant Human IKBKE, GST-tagged E.coli GST
Human IKBKE-5253HCL Recombinant Human IKBKE 293 Cell Lysate HEK293 N/A
Human IKBKE-1075H Recombinant Human IKBKE Protein (Q2-V716), GST tagged Insect Cell GST
Human IKBKE-1074H Recombinant Human IKBKE Protein (Q2-V716), Tag Free Insect Cell No tag
Human IKBKE-3352H Recombinant Human IKBKE Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IKBKE-9992HF Active Recombinant Full Length Human IKBKE Protein, GST-tagged Insect (sf21) GST
Mouse IKBKE-8102M Recombinant Mouse IKBKE Protein Mammalian Cell His
Mouse Ikbke-3497M Recombinant Mouse Ikbke Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse IKBKE-4486M-B Recombinant Mouse IKBKE Protein Pre-coupled Magnetic Beads HEK293
Mouse IKBKE-4486M Recombinant Mouse IKBKE Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish IKBKE-847Z Recombinant Zebrafish IKBKE Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IKBKE Related Research Area

IKBKE involved in several pathways and played different roles in them. We selected most pathways IKBKE participated on our site, such as Toll-like receptor signaling pathway, RIG-I-like receptor signaling pathway, Cytosolic DNA-sensing pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IKBKE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Toll-like receptor signaling pathwayMAP2K2B;PIK3R5;CCL5;CD80;PIK3CD;CCL3L3;IL12B;MAPK10;CCL3
RIG-I-like receptor signaling pathwayIRF7;DDX3;NFKB1;CASP8;CASP10;OTUD5A;IFIH1;IFNA21;IFNA13
Cytosolic DNA-sensing pathwayIFNA1;POLR2F;POLR2K;Ifna11;Ifna15;IL18;AIM2;IFNB1;IFNA16
Hepatitis CCD81;IKBKB;PIK3CB;RAF1;MAPK11;IFNA21;OAS1B;IRF7;TYK2
Hepatitis BCASP8;CASP10;PIK3R3;CASP12;CREB3L3;DDX3X;CCND1;OSTN;PRKCG
MeaslesIfna15;FASLG;NFKB1;IRAK4;EIF2AK4;HSPA1L;Il2;IL1A;STAT2
Influenza AIL18;PIK3R5;MX1;MAPK8;IFNGR1;NXF2;FURIN;MAPK3;EIF2AK4
Herpes simplex infectionHNRPKL;CD74A;GTF2I;TBK1;SP100;CASP3A;Ifna11;CYCS;PTPN11B

IKBKE has several biochemical functions, for example, ATP binding, IkappaB kinase activity, K48-linked polyubiquitin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IKBKE itself. We selected most functions IKBKE had, and list some proteins which have the same functions with IKBKE. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCLPXA;CKB;PRKDC;UBE2J1;MAP3K8;VPS4A;CSNK1G2A;EPHA8;DCLK1
IkappaB kinase activityCHUK;IKBKB;IKBKE
K48-linked polyubiquitin bindingVCP;IKBKE;UFD1L;UBXN1
NOT K63-linked polyubiquitin binding
NF-kappaB-inducing kinase activityIRAK1;ALK;IKBKE;RIPK3;ALPK2;MAP3K14;PPP4C
protein bindingDISC1;RPL11;SYMPK;WDR11;TAGLN2;GATC;NR1H3;IFT46;ADRBK1
ubiquitin protein ligase bindingLRPPRC;SPG20;FZD6;TRIB3;UBE2G1;TNFRSF1B;SNCAIP;HIF1A;UBE2K

IKBKE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IKBKE here. Most of them are supplied by our site. Hope this information will be useful for your research of IKBKE.

TANK; CDC37; MAVS; TBKBP1; N/A; DDX3X

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