Recombinant Human IKBKE, GST-tagged

• Cat.No.: IKBKE-14133H
• Product Overview: Recombinant Human IKBKE protein, fused to GST-tag, was expressed in E.coli and purified by GSH-sepharose.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: C-term-350a.a.
• Description: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).
• Storage: The protein is stored in PBS buffer at -20℃. Avoid repeated freezing and thawing cycles.
• Storage Buffer: 1M PBS (58mM Na2HPO4,17mM NaH2PO4, 68mM NaCl, pH8. ) added with 100mM GSH and 1% Triton X-100,15%glycerol.

Gene Information

• Gene Name: IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon [ Homo sapiens ]
• Official Symbol: IKBKE
• Synonyms: IKBKE; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon; inhibitor of nuclear factor kappa-B kinase subunit epsilon; IKK i; IKKE; KIAA0151; IKK-epsilon; I-kappa-B kinase epsilon; inducible IkappaB kinase; IKK-related kinase epsilon; inducible I kappa-B kinase; IKKI; IKK-E; IKK-i; MGC125294; MGC125295; MGC125297
• Gene ID: 9641
• mRNA Refseq: NM_001193321
• Protein Refseq: NP_001180250
• MIM: 605048
• UniProt ID: Q14164
• Chromosome Location: 1q31
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon, organism-specific biosystem; Cytosolic DNA-sensing pathway, organism-specific biosystem; Cytosolic DNA-sensing pathway, conserved biosystem; Hepatitis C, organism-specific biosystem; Hepatitis C, conserved biosystem; Herpes simplex infection, organism-specific biosystem
• Function: ATP binding; ATP binding; IkappaB kinase activity; NF-kappaB-inducing kinase activity; nucleotide binding; protein binding; protein kinase activity; transferase activity, transferring phosphorus-containing groups