IL1RL1
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Official Full Name
interleukin 1 receptor-like 1
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Background
The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene in mouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the function of helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) and interleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008] -
Synonyms
IL1RL1; interleukin 1 receptor-like 1; T1; ST2; DER4; ST2L; ST2V; FIT-1; IL33R; interleukin-1 receptor-like 1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL1RL1 Related Articles
- IL1RL1 Related Gene Family
IL1RL1 involved in several pathways and played different roles in them. We selected most pathways IL1RL1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1RL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
IL1RL1 has several biochemical functions, for example, cytokine receptor activity, interleukin-1 receptor activity, interleukin-33 binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1RL1 itself. We selected most functions IL1RL1 had, and list some proteins which have the same functions with IL1RL1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cytokine receptor activity | GHR;IL2RGB;CD74;LIFRB;IL4R.1;Il6ra;CRFB2;IL28RA;IL20RA |
| interleukin-1 receptor activity | IL1RAP;IL1RL2;IL1R2;IL1R1;IL18R1;IL1RAPL2;IL1RAPL1A;IL1RL1 |
| interleukin-33 binding | |
| interleukin-33 receptor activity | |
| protein binding | ARAP3;PSMG1;FAM107A;COG4;ALOX12;THOC2;EIF2S1;BCL6;EIF2A |
| receptor signaling protein activity | PLCE1;DOK1;PLCG1;CD19;FLRT2;ARF1;DAXX;FLRT3;NCR1 |
IL1RL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1RL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1RL1.
CLEC7A; IL33; MYD88; IRAK4; TRAF6
- Q&As
- Reviews
Q&As (10)
Ask a questionIL1RL1 has multiple splice variants that differ in signaling capabilities.
IL1RL1 suppresses allergic responses by inhibiting mast cell activation.
IL1RL1 is implicated in rheumatoid arthritis.
IL1RL1 increases the production of IL-4 and IL-13.
IL1RL1 is primarily membrane-bound.
IL1RL1 promotes Th2 cell differentiation.
IL1RL1 binds to IL-33 and IL-36 to initiate signaling.
IL1RL1 expression is altered in lung and breast cancer.
IL1RL1 undergoes glycosylation and phosphorylation.
IL1RL1 expression is upregulated in asthmatic conditions.
Customer Reviews (3)
Write a reviewHigh specificity in ELISA. -
Suitable for flow cytometry. -
Effective in allergy models. -
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