Recombinant Human Interleukin 1 Receptor-Like 1
Cat.No. : | IL1RL1-1637H |
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Cat. No. : | IL1RL1-1637H |
Description : | The protein IL1 R4, also known as T1, ST2, is a member of the interleukin-1 receptor family with a soluble secreted form (sST2) and a transmembrane form (ST2L). The coding gene forms a cytokine receptor gene cluster together with IL1 R1(interleukin 1 receptor, type I), IL1R2(interleukin 1 receptor, type II) and IL1RL2(interleukin 1 receptor-like 2) genes in a region mapped to chromosome 2q12. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. Interleukin (IL)-33 is a specific ligand of ST2L and induces production of Th2 cytokines. |
Source : | Mammalian cells |
State Of Matter : | Lyophilized. |
Purity : | >97% by SDS Page and analyzed by silver stain. |
Endotoxin : | <1.0 EU/µg as determined by the LAL method. |
Molecular Weight : | The predicted molecular weight of Recombinant Human IL-1 R4 is Mr 62.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100 kDa. |
Storage And Stability : | This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. |
Tag : | Non |
Gene Name : | IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ] |
Synonyms : | IL1RL1; interleukin 1 receptor-like 1; T1; ST2; DER4; ST2L; ST2V; FIT-1; MGC32623; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; nterleukin-1 receptor-like 1; Protein ST2; OTTHUMP00000161342 |
Gene ID : | 9173 |
mRNA Refseq : | NM_003856 |
Protein Refseq : | NP_003847 |
MIM : | 601203 |
UniProt ID : | Q01638 |
Chromosome Location : | 2q12 |
Function : | interleukin-1 receptor activity; interleukin-33 receptor activity; protein binding; receptor signaling protein activity |
Products Types
◆ Recombinant Protein | ||
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IL1RL1-2690R | Recombinant Rat IL1RL1 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL1RL1-318H | Recombinant Human IL1RL1 Protein, Fc-tagged | +Inquiry |
IL1RL1-1009H | Active Recombinant Human ST2 Protein | +Inquiry |
IL1RL1-775H | Recombinant Human IL1RL1 protein(Met1-Phe328) | +Inquiry |
◆ Lysates | ||
IL1RL1-1883HCL | Recombinant Human IL1RL1 cell lysate | +Inquiry |
IL1RL1-2481HCL | Recombinant Human IL1RL1 cell lysate | +Inquiry |
IL1RL1-001MCL | Recombinant Mouse IL1RL1 cell lysate | +Inquiry |
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Not For Human Consumption!
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Customer Reviews (3)
Write a reviewHigh specificity in ELISA.
Suitable for flow cytometry.
Effective in allergy models.
Q&As (10)
Ask a questionIL1RL1 has multiple splice variants that differ in signaling capabilities.
IL1RL1 suppresses allergic responses by inhibiting mast cell activation.
IL1RL1 is implicated in rheumatoid arthritis.
IL1RL1 increases the production of IL-4 and IL-13.
IL1RL1 is primarily membrane-bound.
IL1RL1 promotes Th2 cell differentiation.
IL1RL1 binds to IL-33 and IL-36 to initiate signaling.
IL1RL1 expression is altered in lung and breast cancer.
IL1RL1 undergoes glycosylation and phosphorylation.
IL1RL1 expression is upregulated in asthmatic conditions.
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