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Recombinant Human Interleukin 1 Receptor-Like 1

Cat.No. : IL1RL1-1637H
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Cat. No. : IL1RL1-1637H
Description : The protein IL1 R4, also known as T1, ST2, is a member of the interleukin-1 receptor family with a soluble secreted form (sST2) and a transmembrane form (ST2L). The coding gene forms a cytokine receptor gene cluster together with IL1 R1(interleukin 1 receptor, type I), IL1R2(interleukin 1 receptor, type II) and IL1RL2(interleukin 1 receptor-like 2) genes in a region mapped to chromosome 2q12. As an important mediator involved in many immune and inflammatory responses, this cytokine has been implicated as a regulator of both the development and effector phases of type 2 helper T cell responses, and as a negative feedback modulator of macrophage pro-inflammatory function. Interleukin (IL)-33 is a specific ligand of ST2L and induces production of Th2 cytokines.
Source : Mammalian cells
State Of Matter : Lyophilized.
Purity : >97% by SDS Page and analyzed by silver stain.
Endotoxin : <1.0 EU/µg as determined by the LAL method.
Molecular Weight : The predicted molecular weight of Recombinant Human IL-1 R4 is Mr 62.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 100 kDa.
Storage And Stability : This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.
Tag : Non
Gene Name : IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ]
Synonyms : IL1RL1; interleukin 1 receptor-like 1; T1; ST2; DER4; ST2L; ST2V; FIT-1; MGC32623; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; nterleukin-1 receptor-like 1; Protein ST2; OTTHUMP00000161342
Gene ID : 9173
mRNA Refseq : NM_003856
Protein Refseq : NP_003847
MIM : 601203
UniProt ID : Q01638
Chromosome Location : 2q12
Function : interleukin-1 receptor activity; interleukin-33 receptor activity; protein binding; receptor signaling protein activity

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
07/25/2019

    High specificity in ELISA.

    01/30/2017

      Suitable for flow cytometry.

      07/13/2016

        Effective in allergy models.

        Q&As (10)

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        Are there any splice variants of IL1RL1? 02/20/2022

        IL1RL1 has multiple splice variants that differ in signaling capabilities.

        What is the role of IL1RL1 in allergic responses? 11/15/2021

        IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

        Does IL1RL1 have a role in autoimmune diseases? 10/09/2021

        IL1RL1 is implicated in rheumatoid arthritis.

        How does IL1RL1 affect cytokine production? 11/21/2020

        IL1RL1 increases the production of IL-4 and IL-13.

        What is the subcellular localization of IL1RL1? 08/13/2020

        IL1RL1 is primarily membrane-bound.

        Does IL1RL1 influence T-cell differentiation? 02/29/2020

        IL1RL1 promotes Th2 cell differentiation.

        How does IL1RL1 interact with its ligands? 01/17/2020

        IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

        Is IL1RL1 expression altered in any cancers? 05/09/2018

        IL1RL1 expression is altered in lung and breast cancer.

        What post-translational modifications occur on IL1RL1? 03/28/2017

        IL1RL1 undergoes glycosylation and phosphorylation.

        How is IL1RL1 expression regulated in asthmatic conditions? 08/23/2016

        IL1RL1 expression is upregulated in asthmatic conditions.

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