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Recombinant Human IL1RL1 protein, Fc-tagged

Cat.No. : IL1RL1-773H
Product Overview : Recombinant Human IL1RL1 protein (Lys19-Pro323), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293).
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Description : Interleukin 1 receptor-like 1 (IL1RL1) is also known as ST2, DER4, FIT-1, IL33R, ST2L, ST2V, which belongs to the interleukin-1 receptor family. IL1RL1 contains three Ig-like C2-type (immunoglobulin-like) domains and one TIR domain. IL1RL1 is receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. IL1RL1 possibly involved in helper T-cell function. IL1RL1 can interact with MYD88, IRAK1, IRAK4, and TRAF6.
Source : HEK293
Species : Human
Tag : Fc
Form : Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 61.0 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 305
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IL1RL1
Official Symbol : IL1RL1
Synonyms : IL1RL1; interleukin 1 receptor-like 1; interleukin-1 receptor-like 1; DER4; FIT 1; homolog of mouse growth stimulation expressed; IL33R; ST2; ST2L; ST2V; T1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; FIT-1; MGC32623
Gene ID : 9173
mRNA Refseq : NM_003856
Protein Refseq : NP_003847
MIM : 601203
UniProt ID : Q01638

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
07/25/2019

    High specificity in ELISA.

    01/30/2017

      Suitable for flow cytometry.

      07/13/2016

        Effective in allergy models.

        Q&As (10)

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        Are there any splice variants of IL1RL1? 02/20/2022

        IL1RL1 has multiple splice variants that differ in signaling capabilities.

        What is the role of IL1RL1 in allergic responses? 11/15/2021

        IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

        Does IL1RL1 have a role in autoimmune diseases? 10/09/2021

        IL1RL1 is implicated in rheumatoid arthritis.

        How does IL1RL1 affect cytokine production? 11/21/2020

        IL1RL1 increases the production of IL-4 and IL-13.

        What is the subcellular localization of IL1RL1? 08/13/2020

        IL1RL1 is primarily membrane-bound.

        Does IL1RL1 influence T-cell differentiation? 02/29/2020

        IL1RL1 promotes Th2 cell differentiation.

        How does IL1RL1 interact with its ligands? 01/17/2020

        IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

        Is IL1RL1 expression altered in any cancers? 05/09/2018

        IL1RL1 expression is altered in lung and breast cancer.

        What post-translational modifications occur on IL1RL1? 03/28/2017

        IL1RL1 undergoes glycosylation and phosphorylation.

        How is IL1RL1 expression regulated in asthmatic conditions? 08/23/2016

        IL1RL1 expression is upregulated in asthmatic conditions.

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