Recombinant Mouse Il1rl1, Fc-tagged

• Cat.No.: Il1rl1-515M
• Product Overview: A DNA sequence encoding the mouse ST2 (NP_001020773.1) (Met1-Arg332) was expressed with the Fc region of human IgG1 at the C-terminus.

Specification

• Source: Human Cells
• Species: Mouse
• Tag: Fc
• Form: Lyophilized from sterile PBS, pH7.4.
• Molecular Mass: The recombinant mouse ST2 comprises 544 amino acids and has a predicted molecular mass of 61.8 kDa. The apparent molecular mass of the protein is approximately 93.2 kDa in SDS-PAGE under reducing conditions due to glycosylation.
• Protein length: Met1-Arg332
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >90 % as determined by SDS-PAGE
• Stability: Samples are stable for up to twelve months from date of receipt at -70℃
• Storage: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Reconstitution: Hardcopy of COA with reconstitution instruction is sent along with the products.

Gene Information

• Gene Name: Il1rl1 interleukin 1 receptor-like 1 [ Mus musculus ]
• Official Symbol: Il1rl1
• Synonyms: IL1RL1; interleukin 1 receptor-like 1; interleukin-1 receptor-like 1; T1; protein T1; lymphocyte antigen 84; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1
• Gene ID: 17082
• mRNA Refseq: NM_001025602
• Protein Refseq: NP_001020773
• Function: interleukin-1 receptor activity; interleukin-33 binding; interleukin-33 receptor activity; receptor activity; transmembrane signaling receptor activity

Reviews

07/25/2019

High specificity in ELISA.

01/30/2017

Suitable for flow cytometry.

07/13/2016

Effective in allergy models.

Q&As

Are there any splice variants of IL1RL1?

IL1RL1 has multiple splice variants that differ in signaling capabilities.

What is the role of IL1RL1 in allergic responses?

IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

Does IL1RL1 have a role in autoimmune diseases?

IL1RL1 is implicated in rheumatoid arthritis.

How does IL1RL1 affect cytokine production?

IL1RL1 increases the production of IL-4 and IL-13.

What is the subcellular localization of IL1RL1?

IL1RL1 is primarily membrane-bound.

Does IL1RL1 influence T-cell differentiation?

IL1RL1 promotes Th2 cell differentiation.

How does IL1RL1 interact with its ligands?

IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

Is IL1RL1 expression altered in any cancers?

IL1RL1 expression is altered in lung and breast cancer.

What post-translational modifications occur on IL1RL1?

IL1RL1 undergoes glycosylation and phosphorylation.

How is IL1RL1 expression regulated in asthmatic conditions?

IL1RL1 expression is upregulated in asthmatic conditions.