Recombinant Human IL1RL1 protein, His-tagged

• Cat.No.: IL1RL1-536H
• Product Overview: Recombinant Human IL1RL1 protein(Q01638-2)(Lys19-Phe328), fused with C-terminal His tag, was expressed in HEK293.

Specification

• Source: HEK293
• Species: Human
• Tag: C-His
• Protein length: Lys19-Phe328
• Form: Supplied as 0.22μm filtered solution in PBS (pH 7.4).
• Bio-activity: Immobilized Human IL-33, No Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human IL-1RL1, His Tag with the EC50 of 9.6ng/ml determined by ELISA.
• Molecular Mass: The protein has a predicted MW of 36 kDa. Due to glycosylation, the protein migrates to 50-70 kDa based on Tris-Bis PAGE result.
• Endotoxin: Less than 1EU per μg by the LAL method.
• Purity: > 95% as determined by Tris-Bis PAGE; > 95% as determined by HPLC
• Storage: Valid for 12 months from date of receipt when stored at -80°C; Recommend to aliquot the protein into smaller quantities for optimal storage. Please do not repeated freeze-thaw cycles.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4°C before opening to recover the entire contents.

Gene Information

• Gene Name: IL1RL1 interleukin 1 receptor-like 1 [ Homo sapiens ]
• Official Symbol: IL1RL1
• Synonyms: IL1RL1; interleukin 1 receptor-like 1; interleukin-1 receptor-like 1; DER4; FIT 1; homolog of mouse growth stimulation expressed; IL33R; ST2; ST2L; ST2V; T1; growth stimulation-expressed; interleukin 1 receptor-related protein; homolog of mouse growth stimulation-expressed; FIT-1; MGC32623
• Gene ID: 9173
• mRNA Refseq: NM_003856
• Protein Refseq: NP_003847
• MIM: 601203
• UniProt ID: Q01638

Reviews

07/25/2019

High specificity in ELISA.

01/30/2017

Suitable for flow cytometry.

07/13/2016

Effective in allergy models.

Q&As

Are there any splice variants of IL1RL1?

IL1RL1 has multiple splice variants that differ in signaling capabilities.

What is the role of IL1RL1 in allergic responses?

IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

Does IL1RL1 have a role in autoimmune diseases?

IL1RL1 is implicated in rheumatoid arthritis.

How does IL1RL1 affect cytokine production?

IL1RL1 increases the production of IL-4 and IL-13.

What is the subcellular localization of IL1RL1?

IL1RL1 is primarily membrane-bound.

Does IL1RL1 influence T-cell differentiation?

IL1RL1 promotes Th2 cell differentiation.

How does IL1RL1 interact with its ligands?

IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

Is IL1RL1 expression altered in any cancers?

IL1RL1 expression is altered in lung and breast cancer.

What post-translational modifications occur on IL1RL1?

IL1RL1 undergoes glycosylation and phosphorylation.

How is IL1RL1 expression regulated in asthmatic conditions?

IL1RL1 expression is upregulated in asthmatic conditions.