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Active Recombinant Mouse IL1RL1, MIgG2a Fc-tagged

Cat.No. : IL1RL1-503M
Product Overview : The extracellular domain of mouse IL-33R[ST2] (NP_001020773.1) (Ser27-Ser342) is fused to the N-terminus of the Fc region of mouse IgG2a was expressed in CHO cell.
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Description : The protein encoded by this gene is a member of the interleukin 1 receptor family. Studies of the similar gene inmouse suggested that this receptor can be induced by proinflammatory stimuli, and may be involved in the functionof helper T cells. This gene, interleukin 1 receptor, type I (IL1R1), interleukin 1 receptor, type II (IL1R2) andinterleukin 1 receptor-like 2 (IL1RL2) form a cytokine receptor gene cluster in a region mapped to chromosome2q12. Alternative splicing of this gene results in multiple transcript variants
Source : CHO cell
Species : Mouse
Tag : MIgG2a Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its ability to bind Recombinant Mouse IL‑33 in a functional ELISA.
Molecular Mass : 63KDa (monomer)
AA Sequence : Ser27-Ser342)
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : >98%, by SDS-PAGE under reducing conditions
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Protein length : Ser27-Ser342
Gene Name : Il1rl1 interleukin 1 receptor-like 1 [ Mus musculus ]
Official Symbol : IL1RL1
Synonyms : IL1RL1; interleukin 1 receptor-like 1; interleukin-1 receptor-like 1; T1; protein T1; lymphocyte antigen 84; St2; DER4; Ly84; ST2L; Fit-1; T1/ST2; St2-rs1;
Gene ID : 17082
mRNA Refseq : NM_001025602
Protein Refseq : NP_001020773
Function : interleukin-1 receptor activity; interleukin-33 binding; interleukin-33 receptor activity; receptor activity; transmembrane signaling receptor activity;

Not For Human Consumption!

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Customer Reviews (3)

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Reviews
07/25/2019

    High specificity in ELISA.

    01/30/2017

      Suitable for flow cytometry.

      07/13/2016

        Effective in allergy models.

        Q&As (10)

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        Are there any splice variants of IL1RL1? 02/20/2022

        IL1RL1 has multiple splice variants that differ in signaling capabilities.

        What is the role of IL1RL1 in allergic responses? 11/15/2021

        IL1RL1 suppresses allergic responses by inhibiting mast cell activation.

        Does IL1RL1 have a role in autoimmune diseases? 10/09/2021

        IL1RL1 is implicated in rheumatoid arthritis.

        How does IL1RL1 affect cytokine production? 11/21/2020

        IL1RL1 increases the production of IL-4 and IL-13.

        What is the subcellular localization of IL1RL1? 08/13/2020

        IL1RL1 is primarily membrane-bound.

        Does IL1RL1 influence T-cell differentiation? 02/29/2020

        IL1RL1 promotes Th2 cell differentiation.

        How does IL1RL1 interact with its ligands? 01/17/2020

        IL1RL1 binds to IL-33 and IL-36 to initiate signaling.

        Is IL1RL1 expression altered in any cancers? 05/09/2018

        IL1RL1 expression is altered in lung and breast cancer.

        What post-translational modifications occur on IL1RL1? 03/28/2017

        IL1RL1 undergoes glycosylation and phosphorylation.

        How is IL1RL1 expression regulated in asthmatic conditions? 08/23/2016

        IL1RL1 expression is upregulated in asthmatic conditions.

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