IL22RA2
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Official Full Name
interleukin 22 receptor, alpha 2
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Background
The protein encoded by this gene is a soluble class II cytokine receptor. This protein has been shown to specifically bind to interleukin 22 (IL22), block the interaction of IL22 with its cell surface receptor, and thus inhibit IL22 activity. This protein functions as an IL22 antagonist, and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
IL22RA2; interleukin 22 receptor, alpha 2; interleukin-22 receptor subunit alpha-2; CRF2 S1; IL 22BP; zcytoR16; IL-22R-alpha-2; class II cytokine receptor; IL-22 receptor subunit alpha-2; interleukin 22-binding protein; interleukin-22-binding protein; cyt;
- Involved Pathway
- Protein Function
- Interacting Protein
- IL22RA2 Related Articles
IL22RA2 involved in several pathways and played different roles in them. We selected most pathways IL22RA2 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22RA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | CCL4;CXCR4;IFNA12;IL11;EGFRA;TNFRSF12A;EPOR;TNFRSF9A;GM2002 |
| Jak-STAT signaling pathway | IL28A;AKT3A;SOCS3B;MPL;SOCS4;CSH1;GM-CSF;IFNPHI1;PIK3CG |
IL22RA2 has several biochemical functions, for example, interleukin-22 binding, interleukin-22 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22RA2 itself. We selected most functions IL22RA2 had, and list some proteins which have the same functions with IL22RA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-22 binding | |
| interleukin-22 receptor activity |
IL22RA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22RA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22RA2.
IL22
- Q&As
- Reviews
Q&As (10)
Ask a questionIL22RA2 binds to IL22, acting as a decoy receptor.
IL22RA2 is a potential therapeutic target for autoimmune diseases.
IL22RA2 influences the JAK-STAT and NF-κB pathways.
IL22RA2 expression correlates with disease severity in psoriasis.
IL22RA2 has high binding kinetics with IL22.
IL22RA2 is involved in maintaining epithelial barrier integrity.
IL22RA2 expression is upregulated during bacterial infection.
The turnover rate of IL22RA2 in cells is approximately 24 hours.
IL22RA2 has multiple alternative splicing variants.
IL22RA2 undergoes phosphorylation.
Customer Reviews (3)
Write a reviewPotent in Th17 activation. -
High specificity. -
Good for cytokine assays. -
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