IL22RA2 Protein


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Official Full Name interleukin 22 receptor, alpha 2
Background The protein encoded by this gene is a soluble class II cytokine receptor. This protein has been shown to specifically bind to interleukin 22 (IL22), block the interaction of IL22 with its cell surface receptor, and thus inhibit IL22 activity. This protein functions as an IL22 antagonist, and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
Synonyms IL22RA2; interleukin 22 receptor, alpha 2; interleukin-22 receptor subunit alpha-2; CRF2 S1; IL 22BP; zcytoR16; IL-22R-alpha-2; class II cytokine receptor; IL-22 receptor subunit alpha-2; interleukin 22-binding protein; interleukin-22-binding protein; cyt
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Fc
    • His
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL22RA2-870H Active Recombinant Human IL22RA2 Protein, Fc Chimera Mammalian cells Fc Inquiry
    Mouse Il22ra2-5656M Active Recombinant Mouse Interleukin 22 Receptor, Alpha 2, Fc-tagged Mammalian cells Fc Inquiry
    Human IL22RA2-2258H Recombinant Human IL22RA2, His tagged Human Cell His Inquiry
    Human IL22RA2-2259H Recombinant Human IL22RA2, Fc-His tagged Human Cell Fc/His Inquiry
    Mouse Il22ra2-1323M Recombinant Mouse Il22ra2 protein, His-tagged E.coli His Inquiry
    Mouse IL22RA2-8155M Recombinant Mouse IL22RA2 Protein Mammalian Cell His Inquiry
    Rat Il22ra2-1324R Recombinant Rat Il22ra2 protein, His-tagged E.coli His Inquiry
    Rat IL22RA2-3040R Recombinant Rat IL22RA2 Protein Mammalian Cell His Inquiry
    Rat Il22ra2-555R Recombinant Rat Il22ra2, Fc-tagged Human Cell Fc Inquiry
    Zebrafish IL22RA2-4274Z Recombinant Zebrafish IL22RA2 Mammalian Cell His Inquiry
    Human IL22RA2-2586HCL Recombinant Human IL22RA2 cell lysate Human Cell N/A Inquiry
    Rat IL22RA2-739RCL Recombinant Rat IL22RA2 cell lysate Human Cell N/A Inquiry
    Human IL22RA2-2302H Recombinant Human IL22RA2 Protein, His-tagged E.coli N-His Inquiry
    Human IL22RA2-439H Recombinant Human IL22RA2 Protein (Met1-Pro263), His-tagged HEK293 His Inquiry
    Human IL22RA2-450H Recombinant Human IL22RA2 Protein, Fc-tagged HEK293 Fc Inquiry

    IL22RA2 involved in several pathways and played different roles in them. We selected most pathways IL22RA2 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22RA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction Il6ra; INHBE; CXCL5; TNFRSF6B; KITLG; LTBR; CXCL14; IL12BA; TNFSF13; ACVR1B
    Jak-STAT signaling pathway IL15; SOCS9; GFAP; PTPN11B; IFNPHI1; IL17D; IL12BA; HRASB; Ifna11; IFNGR2

    IL22RA2 has several biochemical functions, for example, interleukin-22 binding, interleukin-22 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22RA2 itself. We selected most functions IL22RA2 had, and list some proteins which have the same functions with IL22RA2. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-22 binding IL22RA2
    interleukin-22 receptor activity IL22RA2

    IL22RA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22RA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22RA2.


    Wettich, T; Muller-Ladner, U; et al. Effects of Tocilizumab Therapy on Bone Mineral Density, Markers of Bone Metabolism and Disease Activity in TNF-alpha Inadequate Responders with Active Rheumatoid Arthritis. AKTUELLE RHEUMATOLOGIE 39:370-374(2014).
    Johnston, A; Guzman, AM; et al. Early tissue responses in psoriasis to the antitumour necrosis factor-alpha biologic etanercept suggest reduced interleukin-17 receptor expression and signalling. BRITISH JOURNAL OF DERMATOLOGY 171:97-107(2014).

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