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  • Official Full Name

    interleukin 22 receptor, alpha 2

  • Overview

    The protein encoded by this gene is a soluble class II cytokine receptor. This protein has been shown to specifically bind to interleukin 22 (IL22), block the interaction of IL22 with its cell surface receptor, and thus inhibit IL22 activity. This protein functions as an IL22 antagonist, and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms

    IL22RA2; interleukin 22 receptor, alpha 2; interleukin-22 receptor subunit alpha-2; CRF2 S1; IL 22BP; zcytoR16; IL-22R-alpha-2; class II cytokine receptor; IL-22 receptor subunit alpha-2; interleukin 22-binding protein; interleukin-22-binding protein; cyt;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • His (Fc)
  • Avi
  • hFc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL22RA2-870H Active Recombinant Human IL22RA2 Protein, Fc Chimera Mammalian cells Fc
Human IL22RA2-2258H Recombinant Human IL22RA2, His tagged Human Cell His
Human IL22RA2-2259H Recombinant Human IL22RA2 protein, His&hFc-tagged HEK293 His&hFc Met1-Pro231
Human IL22RA2-2586HCL Recombinant Human IL22RA2 cell lysate Human Cell N/A
Human IL22RA2-439H Recombinant Human IL22RA2 Protein (Met1-Pro263), His-tagged HEK293 His Met1-Pro263
Human IL22RA2-2302H Recombinant Human IL22RA2 Protein, His-tagged E.coli N-His Thr22-Pro263
Human IL22RA2-450H Recombinant Human IL22RA2 Protein, Fc-tagged HEK293 Fc Met1-Pro263
Human IL22RA2-100H Recombinant Human IL22RA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IL22RA2-2699H Active Recombinant Human IL22RA2 protein, His-tagged HEK293 His Thr22-Pro231
Human IL22RA2-100H-B Recombinant Human IL22RA2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Il22ra2-5656M Active Recombinant Mouse Interleukin 22 Receptor, Alpha 2, Fc-tagged Mammalian cells Fc
Mouse Il22ra2-1323M Recombinant Mouse Il22ra2 protein, His-tagged E.coli His Gln31~Lys223
Mouse IL22RA2-8155M Recombinant Mouse IL22RA2 Protein Mammalian Cell His
Mouse Il22ra2-70M Recombinant Mouse Il22ra2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il22ra2-70M-B Recombinant Mouse Il22ra2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Il22ra2-6744M Recombinant Mouse Il22ra2 Protein (Full Length), Fc tagged Mammalian cells Fc Full Length
Mouse Il22ra2-6743M Recombinant Mouse Il22ra2 Protein (Full Length), C-His tagged Mammalian cells C-His Full Length
Rat Il22ra2-555R Recombinant Rat Il22ra2, Fc-tagged Human Cell Fc Met1-Pro229
Rat IL22RA2-3040R Recombinant Rat IL22RA2 Protein Mammalian Cell His
Rat Il22ra2-1324R Recombinant Rat Il22ra2 protein, His-tagged E.coli His Gln30~Ile228
Rat IL22RA2-739RCL Recombinant Rat IL22RA2 cell lysate Human Cell N/A
Rat IL22RA2-2695R Recombinant Rat IL22RA2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat IL22RA2-2695R-B Recombinant Rat IL22RA2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish IL22RA2-4274Z Recombinant Zebrafish IL22RA2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • IL22RA2 Related Articles

IL22RA2 involved in several pathways and played different roles in them. We selected most pathways IL22RA2 participated on our site, such as Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22RA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL18R1;Il6ra;IFNGR2;CSF1R;TNFSF13;IL20RA;PDGFAB;CTF1;IL12BA
Jak-STAT signaling pathwayIFNB1;SOCS4;IL15RA;Gh;EP300;IFNB;Ifna15;CSH1;STAM2

IL22RA2 has several biochemical functions, for example, interleukin-22 binding, interleukin-22 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22RA2 itself. We selected most functions IL22RA2 had, and list some proteins which have the same functions with IL22RA2. You can find most of the proteins on our site.

Function Related Protein
interleukin-22 binding
interleukin-22 receptor activity

IL22RA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22RA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22RA2.


Wettich, T; Muller-Ladner, U; et al. Effects of Tocilizumab Therapy on Bone Mineral Density, Markers of Bone Metabolism and Disease Activity in TNF-alpha Inadequate Responders with Active Rheumatoid Arthritis. AKTUELLE RHEUMATOLOGIE 39:370-374(2014).
Johnston, A; Guzman, AM; et al. Early tissue responses in psoriasis to the antitumour necrosis factor-alpha biologic etanercept suggest reduced interleukin-17 receptor expression and signalling. BRITISH JOURNAL OF DERMATOLOGY 171:97-107(2014).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How does IL22RA2 interact with IL22 at the molecular level? 09/30/2022

IL22RA2 binds to IL22, acting as a decoy receptor.

Can IL22RA2 be targeted for autoimmune disease therapy? 08/23/2022

IL22RA2 is a potential therapeutic target for autoimmune diseases.

What cellular pathways are influenced by IL22RA2? 07/07/2022

IL22RA2 influences the JAK-STAT and NF-κB pathways.

Does IL22RA2 expression correlate with disease severity? 03/16/2022

IL22RA2 expression correlates with disease severity in psoriasis.

What are the kinetics of IL22RA2 and IL22 binding? 01/18/2022

IL22RA2 has high binding kinetics with IL22.

Is IL22RA2 involved in epithelial barrier function? 01/09/2022

IL22RA2 is involved in maintaining epithelial barrier integrity.

How does IL22RA2 expression change during infection? 04/14/2020

IL22RA2 expression is upregulated during bacterial infection.

What is the turnover rate of IL22RA2 in cells? 12/31/2018

The turnover rate of IL22RA2 in cells is approximately 24 hours.

Does IL22RA2 have any alternative splicing variants? 06/13/2018

IL22RA2 has multiple alternative splicing variants.

What post-translational modifications occur on IL22RA2? 03/29/2017

IL22RA2 undergoes phosphorylation.

Customer Reviews (3)

Write a review

    Potent in Th17 activation.


      High specificity.


        Good for cytokine assays.

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