IL22RA2
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Official Full Name
interleukin 22 receptor, alpha 2 -
Overview
The protein encoded by this gene is a soluble class II cytokine receptor. This protein has been shown to specifically bind to interleukin 22 (IL22), block the interaction of IL22 with its cell surface receptor, and thus inhibit IL22 activity. This protein functions as an IL22 antagonist, and may be important in the regulation of inflammatory response. Three alternatively spliced transcript variants encoding distinct isoforms have been described. -
Synonyms
IL22RA2;interleukin 22 receptor, alpha 2;interleukin-22 receptor subunit alpha-2;CRF2 S1;IL 22BP;zcytoR16;IL-22R-alpha-2;class II cytokine receptor;IL-22 receptor subunit alpha-2;interleukin 22-binding protein;interleukin-22-binding protein;cyt
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- Mammalian Cells
- E.coli
- Human Cells
- His
- Fc
- Non
- Avi
Involved Pathway
IL22RA2 involved in several pathways and played different roles in them. We selected most pathways IL22RA2 participated on our site, such as Cytokine-cytokine receptor interaction,Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL22RA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Jak-STAT signaling pathway | IFNG1-2,OSM,IL2RGA,LEPR,GHRA,GM13305,CSH2,SOCS1A,PTPN2A,Ifnl2 |
| Cytokine-cytokine receptor interaction | IL7R,CXCL5,IL15RA,TNFRSF1B,BMPR2,GM1987,CCR10,ACVR1,IL21R.1,TNFRSF6B |
Protein Function
IL22RA2 has several biochemical functions, for example, interleukin-22 binding,interleukin-22 receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL22RA2 itself. We selected most functions IL22RA2 had, and list some proteins which have the same functions with IL22RA2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
IL22RA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL22RA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL22RA2.
IL22
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References
- Wettich, T; Muller-Ladner, U; et al. Effects of Tocilizumab Therapy on Bone Mineral Density, Markers of Bone Metabolism and Disease Activity in TNF-alpha Inadequate Responders with Active Rheumatoid Arthritis. AKTUELLE RHEUMATOLOGIE 39:370-374(2014).
- Johnston, A; Guzman, AM; et al. Early tissue responses in psoriasis to the antitumour necrosis factor-alpha biologic etanercept suggest reduced interleukin-17 receptor expression and signalling. BRITISH JOURNAL OF DERMATOLOGY 171:97-107(2014).
