Recombinant Human IL22RA2 protein, His-tagged

Cat.No. : IL22RA2-2258H
Product Overview : Recombinant Human IL-22RA2/IL22BP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Thr22-Pro231) of human IL-22BP/IL-22RA2 (Accession #NP_851826.1) fused with a 6×His tag at the C-terminus.
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Source : HEK293
Species : Human
Tag : C-His
Protein length : Thr22-Pro231
Form : Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.
Bio-activity : Immobilized recombinant Human IL22 at 2μg/mL (100μL/well) can bind recombinant Human IL22BP, the EC50 of Human IL22BP is 10.78 ng/mL.
Storage : Store the lyophilized protein at -20°C to -80 °C for long term.
After reconstitution, the protein solution is stable at -20 °C for 3 months, at 2-8 °C for up to 1 week.
Reconstitution : Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid votex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles.
SDS-PAGE:
Gene Name : IL22RA2 interleukin 22 receptor, alpha 2 [ Homo sapiens ]
Official Symbol : IL22RA2
Synonyms : IL22RA2; interleukin 22 receptor, alpha 2; interleukin-22 receptor subunit alpha-2; CRF2 S1; IL 22BP; zcytoR16; IL-22R-alpha-2; class II cytokine receptor; IL-22 receptor subunit alpha-2; interleukin 22-binding protein; interleukin-22-binding protein; cytokine receptor class-II member 10; cytokine receptor family 2 member 10; cytokine receptor family type 2, soluble 1; CRF2X; CRF2-10; CRF2-S1; IL-22BP; IL-22RA2; MGC150509; MGC150510;
Gene ID : 116379
mRNA Refseq : NM_052962
Protein Refseq : NP_443194
MIM : 606648
UniProt ID : Q969J5

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does IL22RA2 interact with IL22 at the molecular level? 09/30/2022

IL22RA2 binds to IL22, acting as a decoy receptor.

Can IL22RA2 be targeted for autoimmune disease therapy? 08/23/2022

IL22RA2 is a potential therapeutic target for autoimmune diseases.

What cellular pathways are influenced by IL22RA2? 07/07/2022

IL22RA2 influences the JAK-STAT and NF-κB pathways.

Does IL22RA2 expression correlate with disease severity? 03/16/2022

IL22RA2 expression correlates with disease severity in psoriasis.

What are the kinetics of IL22RA2 and IL22 binding? 01/18/2022

IL22RA2 has high binding kinetics with IL22.

Is IL22RA2 involved in epithelial barrier function? 01/09/2022

IL22RA2 is involved in maintaining epithelial barrier integrity.

How does IL22RA2 expression change during infection? 04/14/2020

IL22RA2 expression is upregulated during bacterial infection.

What is the turnover rate of IL22RA2 in cells? 12/31/2018

The turnover rate of IL22RA2 in cells is approximately 24 hours.

Does IL22RA2 have any alternative splicing variants? 06/13/2018

IL22RA2 has multiple alternative splicing variants.

What post-translational modifications occur on IL22RA2? 03/29/2017

IL22RA2 undergoes phosphorylation.

Customer Reviews (3)

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Reviews
08/26/2020

    Potent in Th17 activation.

    09/26/2017

      High specificity.

      06/21/2016

        Good for cytokine assays.

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