Active Recombinant Mouse Interleukin 22 Receptor, Alpha 2, Fc-tagged
Cat.No. : | Il22ra2-5656M |
Product Overview : | RecombinantMouse Il22ra2 protein was expressed in Murine myeloma celllinewith the Fc part of Mouse IgG2A Glu98-Lys330 (C-terminus) and MouseIl22ra2 Thr19-Pro230 (N-terminus). |
- Specification
- Gene Information
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Cat. No. : | Il22ra2-5656M |
Description : | Il22ra2is a 35-45 kDa secreted glycoprotein belonging to the type II cytokine receptorfamily (CRF). IL-22 signals through a receptor complex consisting of IL-22 R andIL-10 Rβ. Il22ra2 is also a component of the receptor complexes for IL-10,IL-26, IL-28, and IL-29. Il22ra2 is widely expressed, and other cell typesexpress either IL-10 Rα or IL-22 R but not both. The mouse Il22ra2 cDNAencodes a 230 amino acid (aa) precursor that includes a 20 aa signal sequenceand two fibronectin type-III domains. |
Source : | Mammalian cells |
Form : | Lyophilizedfrom a 0.2 μm filtered solution in PBS. |
N-terminalSequence : | Thr19 |
MolecularWeight : | 51.8 kDa (monomer) |
Activity : | Measuredby its binding ability in a functional ELISA. In a 100 μL reaction mixturecontaining biotinylated rmIL-22 at 25 ng/mL and rm Il22ra2/FcChimera dilutions at 0.03-20 μg/mL, the concentration of rm Il22ra2/Fc Chimerathat produces 50% of the optimal binding response is found to be approximately1-4 μg/mL. |
Endotoxin Level : | <1.0EU per 1μg of the protein by the LAL method. |
SDS-PAGE : | 60-70kDa, reducing conditions. |
Purity : | >90%,by SDS-PAGE under reducing conditions and visualized by silver stain. |
Reconstitution : | 250 μg/mLin sterile PBS |
Storage : | Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution. |
Gene Name : | Il22ra2 interleukin 22receptor, alpha 2 [ Mus musculus ] |
Official Symbol : | Il22ra2 |
Synonyms : | Il22ra2; interleukin22 receptor, alpha 2; CRF2X; CRF2-10; CRF2-s1; Il-22bp; interleukin-22receptor subunit alpha-2; IL22BP; IL-22RA2; zcytoR16; IL-22R-alpha-2; IL-22receptor subunit alpha-2; interleukin-22-binding protein; cytokine receptorfamily II soluble 1; cytokine receptor family type 2, soluble 1 |
Gene ID : | 237310 |
mRNA Refseq : | NM_178258 |
Protein Refseq : | NP_839989 |
UniProt ID : | Q08AV1 |
Chromosome Location : | 10 |
Pathway : | Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway |
Function : | interleukin-22binding; interleukin-22 receptor activity; protein binding; receptor activity |
Products Types
◆ Recombinant Protein | ||
IL22RA2-2695R | Recombinant Rat IL22RA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL22RA2-100H | Recombinant Human IL22RA2 Protein, His (Fc)-Avi-tagged | +Inquiry |
IL22RA2-439H | Recombinant Human IL22RA2 Protein (Met1-Pro263), His-tagged | +Inquiry |
IL22RA2-2302H | Recombinant Human IL22RA2 Protein, His-tagged | +Inquiry |
IL22RA2-450H | Recombinant Human IL22RA2 Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
IL22RA2-739RCL | Recombinant Rat IL22RA2 cell lysate | +Inquiry |
IL22RA2-2586HCL | Recombinant Human IL22RA2 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionIL22RA2 binds to IL22, acting as a decoy receptor.
IL22RA2 is a potential therapeutic target for autoimmune diseases.
IL22RA2 influences the JAK-STAT and NF-κB pathways.
IL22RA2 expression correlates with disease severity in psoriasis.
IL22RA2 has high binding kinetics with IL22.
IL22RA2 is involved in maintaining epithelial barrier integrity.
IL22RA2 expression is upregulated during bacterial infection.
The turnover rate of IL22RA2 in cells is approximately 24 hours.
IL22RA2 has multiple alternative splicing variants.
IL22RA2 undergoes phosphorylation.
Customer Reviews (3)
Write a reviewPotent in Th17 activation.
High specificity.
Good for cytokine assays.
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