Active Recombinant Mouse Interleukin 22 Receptor, Alpha 2, Fc-tagged

Cat.No. : Il22ra2-5656M
Product Overview : RecombinantMouse Il22ra2 protein was expressed in Murine myeloma celllinewith the Fc part of Mouse IgG2A Glu98-Lys330 (C-terminus) and MouseIl22ra2 Thr19-Pro230 (N-terminus).
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Cat. No. : Il22ra2-5656M
Description : Il22ra2is a 35-45 kDa secreted glycoprotein belonging to the type II cytokine receptorfamily (CRF). IL-22 signals through a receptor complex consisting of IL-22 R andIL-10 Rβ. Il22ra2 is also a component of the receptor complexes for IL-10,IL-26, IL-28, and IL-29. Il22ra2 is widely expressed, and other cell typesexpress either IL-10 Rα or IL-22 R but not both. The mouse Il22ra2 cDNAencodes a 230 amino acid (aa) precursor that includes a 20 aa signal sequenceand two fibronectin type-III domains.
Source : Mammalian cells
Form : Lyophilizedfrom a 0.2 μm filtered solution in PBS.
N-terminalSequence : Thr19
MolecularWeight : 51.8 kDa (monomer)
Activity : Measuredby its binding ability in a functional ELISA. In a 100 μL reaction mixturecontaining biotinylated rmIL-22 at 25 ng/mL and rm Il22ra2/FcChimera dilutions at 0.03-20 μg/mL, the concentration of rm Il22ra2/Fc Chimerathat produces 50% of the optimal binding response is found to be approximately1-4 μg/mL.
Endotoxin Level : <1.0EU per 1μg of the protein by the LAL method.
SDS-PAGE : 60-70kDa, reducing conditions.
Purity : >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
Reconstitution : 250 μg/mLin sterile PBS
Storage : Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied. 1month, 2 to 8°C under sterile conditions after reconstitution. 3 months, -20 to-70°C under sterile conditions after reconstitution.
Gene Name : Il22ra2 interleukin 22receptor, alpha 2 [ Mus musculus ]
Official Symbol : Il22ra2
Synonyms : Il22ra2; interleukin22 receptor, alpha 2; CRF2X; CRF2-10; CRF2-s1; Il-22bp; interleukin-22receptor subunit alpha-2; IL22BP; IL-22RA2; zcytoR16; IL-22R-alpha-2; IL-22receptor subunit alpha-2; interleukin-22-binding protein; cytokine receptorfamily II soluble 1; cytokine receptor family type 2, soluble 1
Gene ID : 237310
mRNA Refseq : NM_178258
Protein Refseq : NP_839989
UniProt ID : Q08AV1
Chromosome Location : 10
Pathway : Cytokine-cytokinereceptor interaction; Jak-STAT signaling pathway
Function : interleukin-22binding; interleukin-22 receptor activity; protein binding; receptor activity

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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How does IL22RA2 interact with IL22 at the molecular level? 09/30/2022

IL22RA2 binds to IL22, acting as a decoy receptor.

Can IL22RA2 be targeted for autoimmune disease therapy? 08/23/2022

IL22RA2 is a potential therapeutic target for autoimmune diseases.

What cellular pathways are influenced by IL22RA2? 07/07/2022

IL22RA2 influences the JAK-STAT and NF-κB pathways.

Does IL22RA2 expression correlate with disease severity? 03/16/2022

IL22RA2 expression correlates with disease severity in psoriasis.

What are the kinetics of IL22RA2 and IL22 binding? 01/18/2022

IL22RA2 has high binding kinetics with IL22.

Is IL22RA2 involved in epithelial barrier function? 01/09/2022

IL22RA2 is involved in maintaining epithelial barrier integrity.

How does IL22RA2 expression change during infection? 04/14/2020

IL22RA2 expression is upregulated during bacterial infection.

What is the turnover rate of IL22RA2 in cells? 12/31/2018

The turnover rate of IL22RA2 in cells is approximately 24 hours.

Does IL22RA2 have any alternative splicing variants? 06/13/2018

IL22RA2 has multiple alternative splicing variants.

What post-translational modifications occur on IL22RA2? 03/29/2017

IL22RA2 undergoes phosphorylation.

Customer Reviews (3)

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Reviews
08/26/2020

    Potent in Th17 activation.

    09/26/2017

      High specificity.

      06/21/2016

        Good for cytokine assays.

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