Il6ra
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Official Full Name
interleukin 6 receptor, alpha
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Background
This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine;that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is;a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor;subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the;pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively;spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on;chromosome 9. -
Synonyms
IL6RA; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; gp80; CD 126; CD126; CD126 antigen; IL 6R 1; IL 6R alpha; IL 6R; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; Il6r; IL6RA_HUMAN; Interleukin 6 receptor; Membrane glycoprotein 80; IL-6 receptor alpha chain; IL-6R;
- Involved Pathway
- Protein Function
- Interacting Protein
- Il6ra Related Gene Family
- Il6ra Related Research Area
Il6ra involved in several pathways and played different roles in them. We selected most pathways Il6ra participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il6ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | BMPR1AA;XCL2;CCR5;CXCL16;PF4;CXCL13;IL12A;BMP2;THPO |
| HIF- signaling pathway | CUL2;Trf;INS2;EIF4E1B;NPPA;PIK3CG;ANGPT2;PGK1;IL6 |
| PIK-Akt signaling pathway | HGF;ITGB4;ITGA4;LAMA5;INSR;MAPK3;GNG5;ITGA3;GNB3 |
| Jak-STAT signaling pathway | SOCS5B;Ifnlr1;IFNA12;IL12A;CNTFR;IFNA2;AOX2P;PIK3R2;IL6ST |
| Hematopoietic cell lineage | ITGB3;IL6R;CR1;IL7;CD1D;IL6;IL11RA;ITGAM;Itgam&Itgb2 |
| Non-alcoholic fatty liver disease (NAFLD) | FASLG;UQCRC2;ADIPOQ;CEBPA;COX8C;INSR;LEPR;NDUFS5;NDUFB11 |
Il6ra has several biochemical functions, for example, ciliary neurotrophic factor binding, contributes_to ciliary neurotrophic factor receptor activity, cytokine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il6ra itself. We selected most functions Il6ra had, and list some proteins which have the same functions with Il6ra. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ciliary neurotrophic factor binding | Il6ra;IL6R |
| contributes_to ciliary neurotrophic factor receptor activity | CNTFR;LIFR;IL6R;Il6ra |
| cytokine receptor activity | IL13RA1;IL20RA;CRFB17;PRLRA;CD74;IL2RGB;CRFB15;IL12B;CSF3R |
| enzyme binding | BCL10;ARPC4;CYP2A6;UBE2L3;SCNM1;CAT;TSPAN10;CDK19;RCOR3 |
| interleukin-6 binding | IL6R;Il6ra |
| interleukin-6 receptor activity | |
| contributes_to interleukin-6 receptor activity | Il6ra;IL6ST;IL6R |
| contributes_to interleukin-6 receptor binding | Il6ra;IL6;IL6ST;IL6R |
| protein homodimerization activity | MTERFD3;ECT2;PVRL3;USF2;VOX;P2RX7;NKX2;CRYBB2;CD8A |
Il6ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il6ra here. Most of them are supplied by our site. Hope this information will be useful for your research of Il6ra.
Il6st
- Q&As
- Reviews
Q&As (6)
Ask a questionIl6ra blocks the binding of the interleukin-6 receptor by acting on it, thereby affecting its immunomodulatory effect and reducing inflammation.
The efficacy of Il6ra is related to the severity of the disease, disease type and individual differences of patients, and should be judged by professional physicians according to the situation.
Il6ra can be used to treat rheumatoid arthritis, psoriasis, alopecia areata and other autoimmune diseases.
Almost all treatments have some kind of side effect, but the occurrence of side effects can be reduced with proper dosing and monitoring.
Recombinant Il6ra inhibits the immune response by inhibiting the cytokine activity of interleukin-6.
In addition to the autoimmune diseases mentioned above, Il6ra may also be used in the future to treat chronic inflammatory bowel disease, neurodegenerative diseases, and cancer.
Customer Reviews (3)
Write a reviewIt has good effect and stability in gene expression regulation. -
Will not interact with other drugs, will not affect. -
The application performance is stable in common colorimetric reactions. -
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