• Official Full Name

    interleukin 6 receptor, alpha

  • Background

    This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine;that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is;a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor;subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the;pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively;spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on;chromosome 9.
  • Synonyms

    IL6RA; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; gp80; CD 126; CD126; CD126 antigen; IL 6R 1; IL 6R alpha; IL 6R; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; Il6r; IL6RA_HUMAN; Interleukin 6 receptor; Membrane glycoprotein 80; IL-6 receptor alpha chain; IL-6R;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Mus musculus (Mouse)
    • Source :
    • CHO
    • CHO cells
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293 cells
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Tag :
    • Fc
    • His
    • His (Fc)
    • Avi
    • human|IgG1|Fc
    • MYC
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Price
    Human IL6RA-345H Recombinant Human IL6RA protein, Fc-tagged HEK293 human/IgG1/Fc
    Human IL6RA-3324H Active Recombinant Human IL6RA protein CHO cells N/A
    Human IL6RA-3322H Active Recombinant Human IL6RA protein HEK293 cells N/A
    Mouse Il6ra-001M Active Recombinant Mouse IL6RA, MIgG2a Fc-tagged CHO Fc
    Mouse Il6ra-2297M Recombinant Mouse Il6ra, His tagged HEK293 His
    Mouse Il6ra-583M Recombinant Mouse Il6ra protein, His-tagged E.coli His
    Mouse IL6RA-8178M Recombinant Mouse IL6RA Protein Mammalian Cell His
    Mouse IL6R-2590MCL Recombinant Mouse IL6R cell lysate Human Cell N/A
    Mouse Il6ra-1246M Recombinant Mouse Il6ra Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse IL6RA-4520M Recombinant Mouse IL6RA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse Il6ra-2298M Recombinant Mouse Il6ra(Leu20-Pro364) Protein, C-6*His-tagged HEK293 His
    Mouse IL6RA-4520M-B Recombinant Mouse IL6RA Protein Pre-coupled Magnetic Beads HEK293
    Mus musculus (Mouse) RFL18677MF Recombinant Full Length Mouse Interleukin-6 Receptor Subunit Alpha(Il6Ra) Protein, His-Tagged E.coli expression system His
    Chicken IL6RA-3467C Recombinant Chicken IL6RA Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • Il6ra Related Gene Family
    • Il6ra Related Research Area

    Il6ra involved in several pathways and played different roles in them. We selected most pathways Il6ra participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il6ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionBMPR1AA;XCL2;CCR5;CXCL16;PF4;CXCL13;IL12A;BMP2;THPO
    HIF- signaling pathwayCUL2;Trf;INS2;EIF4E1B;NPPA;PIK3CG;ANGPT2;PGK1;IL6
    PIK-Akt signaling pathwayHGF;ITGB4;ITGA4;LAMA5;INSR;MAPK3;GNG5;ITGA3;GNB3
    Jak-STAT signaling pathwaySOCS5B;Ifnlr1;IFNA12;IL12A;CNTFR;IFNA2;AOX2P;PIK3R2;IL6ST
    Hematopoietic cell lineageITGB3;IL6R;CR1;IL7;CD1D;IL6;IL11RA;ITGAM;Itgam&Itgb2
    Non-alcoholic fatty liver disease (NAFLD)FASLG;UQCRC2;ADIPOQ;CEBPA;COX8C;INSR;LEPR;NDUFS5;NDUFB11

    Il6ra has several biochemical functions, for example, ciliary neurotrophic factor binding, contributes_to ciliary neurotrophic factor receptor activity, cytokine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il6ra itself. We selected most functions Il6ra had, and list some proteins which have the same functions with Il6ra. You can find most of the proteins on our site.

    Function Related Protein
    ciliary neurotrophic factor bindingIl6ra;IL6R
    contributes_to ciliary neurotrophic factor receptor activityCNTFR;LIFR;IL6R;Il6ra
    cytokine receptor activityIL13RA1;IL20RA;CRFB17;PRLRA;CD74;IL2RGB;CRFB15;IL12B;CSF3R
    enzyme bindingBCL10;ARPC4;CYP2A6;UBE2L3;SCNM1;CAT;TSPAN10;CDK19;RCOR3
    interleukin-6 bindingIL6R;Il6ra
    interleukin-6 receptor activity
    contributes_to interleukin-6 receptor activityIl6ra;IL6ST;IL6R
    contributes_to interleukin-6 receptor bindingIl6ra;IL6;IL6ST;IL6R
    protein homodimerization activityMTERFD3;ECT2;PVRL3;USF2;VOX;P2RX7;NKX2;CRYBB2;CD8A

    Il6ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il6ra here. Most of them are supplied by our site. Hope this information will be useful for your research of Il6ra.


    • Q&As
    • Reviews

    Q&As (6)

    Ask a question
    What is the pharmacological action of Il6ra? 07/10/2021

    Il6ra blocks the binding of the interleukin-6 receptor by acting on it, thereby affecting its immunomodulatory effect and reducing inflammation.

    Which diseases is Il6ra recombinant more effective in treating? 06/21/2021

    The efficacy of Il6ra is related to the severity of the disease, disease type and individual differences of patients, and should be judged by professional physicians according to the situation.

    What diseases can recombinant Il6ra be used to treat? 02/10/2020

    Il6ra can be used to treat rheumatoid arthritis, psoriasis, alopecia areata and other autoimmune diseases.

    Does Il6ra treat diseases with side effects? 08/14/2019

    Almost all treatments have some kind of side effect, but the occurrence of side effects can be reduced with proper dosing and monitoring.

    What is the mechanism of Il6ra? 08/08/2019

    Recombinant Il6ra inhibits the immune response by inhibiting the cytokine activity of interleukin-6.

    What are the clinical prospects of Il6ra? 03/25/2019

    In addition to the autoimmune diseases mentioned above, Il6ra may also be used in the future to treat chronic inflammatory bowel disease, neurodegenerative diseases, and cancer.

    Customer Reviews (3)

    Write a review

      It has good effect and stability in gene expression regulation. -


        Will not interact with other drugs, will not affect. -


          The application performance is stable in common colorimetric reactions. -

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