• Official Full Name

    interleukin 6 receptor, alpha

  • Overview

    This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine;that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is;a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor;subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the;pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively;spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on;chromosome 9.
  • Synonyms

    IL6RA; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; gp80; CD 126; CD126; CD126 antigen; IL 6R 1; IL 6R alpha; IL 6R; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; Il6r; IL6RA_HUMAN; Interleukin 6 receptor; Membrane glycoprotein 80; IL-6 receptor alpha chain; IL-6R;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • CHO
  • CHO cells
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293 cells
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Fc
  • His
  • His (Fc)
  • Avi
  • human|IgG1|Fc
  • MYC
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL6RA-345H Recombinant Human IL6RA protein, Fc-tagged HEK293 human/IgG1/Fc 346
Human IL6RA-3324H Active Recombinant Human IL6RA protein CHO cells N/A
Human IL6RA-3322H Active Recombinant Human IL6RA protein HEK293 cells N/A
Mouse Il6ra-001M Active Recombinant Mouse IL6RA, MIgG2a Fc-tagged CHO Fc
Mouse Il6ra-2297M Recombinant Mouse Il6ra, His tagged HEK293 His Ile 44-Glu 357
Mouse Il6ra-583M Recombinant Mouse Il6ra protein, His-tagged E.coli His Ala52~Ala204
Mouse IL6RA-8178M Recombinant Mouse IL6RA Protein Mammalian Cell His
Mouse IL6R-2590MCL Recombinant Mouse IL6R cell lysate Human Cell N/A
Mouse Il6ra-1246M Recombinant Mouse Il6ra Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse IL6RA-4520M Recombinant Mouse IL6RA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Il6ra-2298M Recombinant Mouse Il6ra(Leu20-Pro364) Protein, C-6*His-tagged HEK293 His
Mouse IL6RA-4520M-B Recombinant Mouse IL6RA Protein Pre-coupled Magnetic Beads HEK293
Mus musculus (Mouse) RFL18677MF Recombinant Full Length Mouse Interleukin-6 Receptor Subunit Alpha(Il6Ra) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (20-460)
Chicken IL6RA-3467C Recombinant Chicken IL6RA Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Il6ra involved in several pathways and played different roles in them. We selected most pathways Il6ra participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il6ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionMET;LOC100033925;CCL16;IL-15RA;CCL4L2;EPO;PLEKHO2;IL5;IL12A
HIF- signaling pathwayEP300;PGK1;INS;ERBB2;CUL2;IL6;CAMK2G;TF;NOX1
PIK-Akt signaling pathwayGNG5;LPAR2;IGF1R;INSR;SGK1;Ifna11;MAP2K1;IL7;NOS3
Jak-STAT signaling pathwayIL12RB1;IL6;CSH2;AKT2;AKT2L;GH2;STAT4;IL13RA2;IL-15RA
Hematopoietic cell lineageIL1R1;IL6R;IL3;CD3G;CD34;IL7;IL1B;EPOR;CD59A
Non-alcoholic fatty liver disease (NAFLD)NDUFS1;NDUFA10;TNFRSF1A;NDUFA1;Casp3;PIK3CG;MLXIPL;ADIPOQ;PRKAB1

Il6ra has several biochemical functions, for example, ciliary neurotrophic factor binding, contributes_to ciliary neurotrophic factor receptor activity, cytokine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il6ra itself. We selected most functions Il6ra had, and list some proteins which have the same functions with Il6ra. You can find most of the proteins on our site.

Function Related Protein
ciliary neurotrophic factor bindingIl6ra;IL6R
contributes_to ciliary neurotrophic factor receptor activityLIFR;Il6ra;IL6R;CNTFR
cytokine receptor activityFLT3;IL20RB;F3A;LIFRB;IL15RA;F3;GHR;IL28RA;LIFRA
interleukin-6 bindingIL6R;Il6ra
interleukin-6 receptor activity
contributes_to interleukin-6 receptor activityIl6ra;IL6R;IL6ST
contributes_to interleukin-6 receptor bindingIl6ra;IL6ST;IL6R;IL6
protein homodimerization activitySLC16A1;MCL1B;UGT1A6B;CIB2;AXIN1;IRAK1;PDCD10;SNX1;SUMF1

Il6ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il6ra here. Most of them are supplied by our site. Hope this information will be useful for your research of Il6ra.


  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the pharmacological action of Il6ra? 07/10/2021

Il6ra blocks the binding of the interleukin-6 receptor by acting on it, thereby affecting its immunomodulatory effect and reducing inflammation.

Which diseases is Il6ra recombinant more effective in treating? 06/21/2021

The efficacy of Il6ra is related to the severity of the disease, disease type and individual differences of patients, and should be judged by professional physicians according to the situation.

What diseases can recombinant Il6ra be used to treat? 02/10/2020

Il6ra can be used to treat rheumatoid arthritis, psoriasis, alopecia areata and other autoimmune diseases.

Does Il6ra treat diseases with side effects? 08/14/2019

Almost all treatments have some kind of side effect, but the occurrence of side effects can be reduced with proper dosing and monitoring.

What is the mechanism of Il6ra? 08/08/2019

Recombinant Il6ra inhibits the immune response by inhibiting the cytokine activity of interleukin-6.

What are the clinical prospects of Il6ra? 03/25/2019

In addition to the autoimmune diseases mentioned above, Il6ra may also be used in the future to treat chronic inflammatory bowel disease, neurodegenerative diseases, and cancer.

Customer Reviews (3)

Write a review

    It has good effect and stability in gene expression regulation.


      Will not interact with other drugs, will not affect.


        The application performance is stable in common colorimetric reactions.

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