Il6ra

  • Official Full Name

    interleukin 6 receptor, alpha

  • Overview

    This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine;that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is;a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor;subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the;pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively;spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on;chromosome 9.

  • Synonyms

    IL6RA;interleukin 6 receptor, alpha;interleukin-6 receptor subunit alpha;gp80;CD 126;CD126;CD126 antigen;IL 6R 1;IL 6R alpha;IL 6R;IL-6 receptor subunit alpha;IL-6R 1;IL-6R subunit alpha;IL-6R-alpha;IL-6RA;Il6r;IL6RA_HUMAN;Interleukin 6 receptor;Membrane glycoprotein 80;IL-6 receptor alpha chain;IL-6R

Recombinant Proteins

  • Mouse
  • Chicken
  • Human
  • Mus musculus
  • HEK293
  • CHO
  • Mammalian Cells
  • E.coli
  • Human Cells
  • His
  • Fc
  • Non
  • DDK
  • Myc
  • Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
Il6ra-2297M Recombinant Mouse Il6ra, His tagged HEK293 Mouse His Ile 44-Glu 357
Il6ra-001M Active Recombinant Mouse IL6RA, MIgG2a Fc-tagged CHO Mouse Fc 20-357 a.a.
IL6RA-3467C Recombinant Chicken IL6RA Mammalian Cells Chicken His
Il6ra-583M Recombinant Mouse Il6ra protein, His-tagged E.coli Mouse His Ala52~Ala204
IL6RA-8178M Recombinant Mouse IL6RA Protein Mammalian Cells Mouse His
IL6R-2590MCL Recombinant Mouse IL6R cell lysate Human Cells Mouse Non
Il6ra-1246M Recombinant Mouse Il6ra Protein, MYC/DDK-tagged HEK293 Mouse DDK&Myc
Il6ra-2298M Recombinant Mouse Il6ra(Leu20-Pro364) Protein, C-6*His-tagged HEK293 Mouse His 20-364 a.a.
IL6RA-3322H Active Recombinant Human IL6RA protein HEK293 Human Non
IL6RA-3324H Active Recombinant Human IL6RA protein CHO Human Non
IL6RA-345H Recombinant Human IL6RA protein, Fc-tagged HEK293 Human Fc 346
IL6RA-4520M Recombinant Mouse IL6RA Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
IL6RA-4520M-B Recombinant Mouse IL6RA Protein Pre-coupled Magnetic Beads HEK293 Mouse
RFL18677MF Recombinant Full Length Mouse Interleukin-6 Receptor Subunit Alpha(Il6Ra) Protein, His-Tagged E.coli Mus musculus His Full L. Full Length of Mature Protein (20-460)

    Involved Pathway

    Il6ra involved in several pathways and played different roles in them. We selected most pathways Il6ra participated on our site, such as Cytokine-cytokine receptor interaction,HIF- signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Il6ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    HIF- signaling pathway TCEB1,TIMP1,RBX1,ENO2,ANGPT4,INS,IFNGR1,CUL2,PDK1,PGK1
    PIK-Akt signaling pathway MDM2,INS,IKBKG,IFNA4,PIK3CG,FGF12,ITGA5,YWHAZ,GNG3,IFNA8
    Cytokine-cytokine receptor interaction PRL2,PF4V1,VEGFA,CCL20B,IL29,PPBP,KITA,GM10591,TNFSF12,GHR
    Non-alcoholic fatty liver disease (NAFLD) IRS2,CEBPA,NDUFS3,KCNA3,NDUFB2,GSK3B,FASLG,IL6R,NR1H3,UQCRQ
    Jak-STAT signaling pathway AOX3L1,PTPN6,GH1,IL27RA,IL4,IFNA14,LEP,EPO,SOCS3,IL12BA
    Hematopoietic cell lineage TFRC,IL9R,CSF1R,FLT3LG,Flt3l,CSF3,Itgam&Itgb2,ITGA1,GM2002,CD3G

    Protein Function

    Il6ra has several biochemical functions, for example, ciliary neurotrophic factor binding,contributes_to ciliary neurotrophic factor receptor activity,cytokine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Il6ra itself. We selected most functions Il6ra had, and list some proteins which have the same functions with Il6ra. You can find most of the proteins on our site.

    Function Related Protein
    cytokine receptor activity GHRA,CRFB17,CSF3R,IL1RL1,IL12RB1,CD74,CRFB12,CRFB4,LIFRA,IL12RB2
    interleukin-6 binding IL6R
    enzyme binding WWOX,PPARG,TSPAN10,UGT1A3,UBE2I,HDHD2,PDE4DIP,A2M,ATP6AP2,CTNNB1
    contributes_to ciliary neurotrophic factor receptor activity LIFR,IL6R,CNTFR
    contributes_to interleukin-6 receptor activity IL6ST,IL6R
    protein homodimerization activity SRF,RXRB,S100A5,CLIC6,ERP29,PVRL2L,FBXO4,CTBP2,S100B,RQCD1
    ciliary neurotrophic factor binding IL6R
    contributes_to interleukin-6 receptor binding IL6,IL6R,IL6ST

    Interacting Protein

    Il6ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Il6ra here. Most of them are supplied by our site. Hope this information will be useful for your research of Il6ra.

    Il6st

    Resources

    Gene Families

    What is the interleukin (IL) factors and IL gene family

    Research Area

    Neuroinflammation
    Immune Regulatory Molecules on Endothelial Cells
    Multiple Sclerosis and Myelin Related Molecules
    Negative Regulators of the Jak/STAT Pathway
    Receptors in the Jak/STAT Pathway
    T Cell Cytokine Signaling
    Other T Cell CD Antigen
    Rheumatoid arthritis Therapeutic Targets
    Monocyte Markers
    Breast Cancer Stem Cell Markers
    Glioma/Medulloblastoma Cancer Stem Cell Markers
    T Follicular Helper (Tfh) Cells
    Th17 Cells
    Th22 Cells
    IL-6 Family Receptors
    MDSC Phenotyping - Positive Markers

    References

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