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Official Full Name interleukin 6 receptor, alpha
Background This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine;that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is;a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor;subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the;pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively;spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on;chromosome 9.
Synonyms IL6RA; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; gp80; CD 126; CD126; CD126 antigen; IL 6R 1; IL 6R alpha; IL 6R; IL-6 receptor subunit alpha; IL-6R 1; IL-6R subunit alpha; IL-6R-alpha; IL-6RA; Il6r; IL6RA_HUMAN; Interleukin 6 receptor; Membrane glycoprotein 80; IL-6 receptor alpha chain; IL-6R
    • Species :
    • Chicken
    • Human
    • Mouse
    • Source :
    • CHO
    • CHO cells
    • E.coli
    • HEK293
    • HEK293 cells
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • Tag :
    • Fc
    • His
    • human
    • IgG1
    • MYC/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL6RA-3322H Recombinant Human IL6RA protein HEK293 cells N/A
    Human IL6RA-3324H Recombinant Human IL6RA protein CHO cells N/A
    Human IL6RA-345H Recombinant Human IL6RA protein, Fc-tagged HEK293 human/IgG1/Fc
    Mouse IL6R-2590MCL Recombinant Mouse IL6R cell lysate Human Cell N/A
    Mouse Il6ra-001M Recombinant Mouse IL6RA, MIgG2a Fc-tagged CHO Fc
    Mouse Il6ra-1246M Recombinant Mouse Il6ra Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Il6ra-2297M Recombinant Mouse Il6ra, His tagged Human Cell His
    Mouse Il6ra-583M Recombinant Mouse Il6ra protein, His-tagged E.coli His
    Mouse IL6RA-8178M Recombinant Mouse IL6RA Protein Mammalian Cell His
    Chicken IL6RA-3467C Recombinant Chicken IL6RA Mammalian Cell His

    il6ra involved in several pathways and played different roles in them. We selected most pathways il6ra participated on our site, such as Cytokine-cytokine receptor interaction, HIF- signaling pathway, PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with il6ra were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction Ifna11; LEPR; IFNG1-2; THPO; KITA; IL7R; CSF3; EGFRA; IL6R; CSF2RA
    HIF- signaling pathway INS1; NFKB1; PIK3CA; GM5506; PIK3CG; RBX1; IGF1; PIK3CB; PLCG2; EGLN1
    PIK-Akt signaling pathway ITGA8; RELA; COL6A5; COL24A1; RHEB; FGF5; IFNA4; ITGA10; IFNA10; GNB3
    Jak-STAT signaling pathway CISHB; IL17D; GM13305; IL28A; STAT6; PIK3CB; IFNG; AOX4; PRL; IL29
    Hematopoietic cell lineage TNF; IL5; ITGA1; CSF1; MS4A1; EPOR; IL1R1; FLT3; IL2RA; IL11RA
    Non-alcoholic fatty liver disease (NAFLD) NDUFA12; Casp3; INSR; MAPK9; UQCRB; UQCR11; UQCRQ; NDUFS5; PIK3CA; NDUFA6

    il6ra has several biochemical functions, for example, ciliary neurotrophic factor binding, contributes_to ciliary neurotrophic factor receptor activity, cytokine receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by il6ra itself. We selected most functions il6ra had, and list some proteins which have the same functions with il6ra. You can find most of the proteins on our site.

    Function Related Protein
    ciliary neurotrophic factor binding IL6R; Il6ra
    contributes_to ciliary neurotrophic factor receptor activity Il6ra; CNTFR; IL6R; LIFR
    cytokine receptor activity IL28RA; IL13RA2; Il4ra; IL1RL1; CRFB12; IL2RGB; CSF3R; PRLRA; IL20RB; Il6ra
    enzyme binding CAV1; EGLN1; PDE4D; POR; RPS3; YES1; HMGA1; MAPK8; HDAC1; CNTNAP2
    interleukin-6 binding Il6ra; IL6R
    interleukin-6 receptor activity Il6ra
    contributes_to interleukin-6 receptor activity IL6R; Il6ra; IL6ST
    contributes_to interleukin-6 receptor binding IL6; Il6ra; IL6ST; IL6R
    protein homodimerization activity APOE; ATPIF1; CAMK2B; GAMT; EFR3A; PTPRO; TIGIT; ADD2; HES1; LRRFIP1

    il6ra has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with il6ra here. Most of them are supplied by our site. Hope this information will be useful for your research of il6ra.



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