Active Recombinant Mouse IL6RA, MIgG2a Fc-tagged

Cat.No. : Il6ra-001M
Product Overview : The extracellular domain of mouse IL-6R (CAA37810.1) (Leu20-Glu357) is fused to the N-terminus of the Fc region of a mouse IgG2a was expressed in CHO cell.
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Description : This gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropiccytokine that regulates cell growth and differentiation and plays an important role in the immune response. TheIL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer(IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmunediseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have beenreported. A pseudogene of this gene is found on chromosome 9
Source : CHO cell
Species : Mouse
Tag : MIgG2a Fc-tagged
Form : Lyophilized from 0.2μm-filtered solution in PBS.
Bio-activity : Measured by its binding ability in a functional ELISA.
Molecular Mass : 64KDa (monomer)
AA Sequence : Leu20-Glu357
Endotoxin : <0.06 eu/μg as determined by lal>
Purity : >98%, by SDS-PAGE under reducing conditions.
Stability : Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
Reconstitution : Reconstitute at 100μg/ml in sterile PBS.
Warning : Avoid freeze/thaw cycles.
Gene Name : Il6ra interleukin 6 receptor, alpha [ Mus musculus ]
Official Symbol : Il6ra
Synonyms : IL6RA; interleukin 6 receptor, alpha; interleukin-6 receptor subunit alpha; IL-6RA; IL-6R 1; IL-6R-alpha; IL-6R subunit alpha; IL-6 receptor alpha chain; IL-6 receptor subunit alpha; Il6r; CD126; IL-6R; MGC30256;
Gene ID : 16194
mRNA Refseq : NM_010559
Protein Refseq : NP_034689
Pathway : Cytokine-cytokine receptor interaction, organism-specific biosystem; Cytokine-cytokine receptor interaction, conserved biosystem; Hematopoietic cell lineage, organism-specific biosystem; Hematopoietic cell lineage, conserved biosystem; IL-6 signaling Pathway, organism-specific biosystem; Jak-STAT signaling pathway, organism-specific biosystem; Jak-STAT signaling pathway, conserved biosystem;
Function : ciliary neurotrophic factor binding; cytokine receptor activity; enzyme binding; interleukin-6 binding; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor activity; protein homodimerization activity; receptor activity;

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (6)

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What is the pharmacological action of Il6ra? 07/10/2021

Il6ra blocks the binding of the interleukin-6 receptor by acting on it, thereby affecting its immunomodulatory effect and reducing inflammation.

Which diseases is Il6ra recombinant more effective in treating? 06/21/2021

The efficacy of Il6ra is related to the severity of the disease, disease type and individual differences of patients, and should be judged by professional physicians according to the situation.

What diseases can recombinant Il6ra be used to treat? 02/10/2020

Il6ra can be used to treat rheumatoid arthritis, psoriasis, alopecia areata and other autoimmune diseases.

Does Il6ra treat diseases with side effects? 08/14/2019

Almost all treatments have some kind of side effect, but the occurrence of side effects can be reduced with proper dosing and monitoring.

What is the mechanism of Il6ra? 08/08/2019

Recombinant Il6ra inhibits the immune response by inhibiting the cytokine activity of interleukin-6.

What are the clinical prospects of Il6ra? 03/25/2019

In addition to the autoimmune diseases mentioned above, Il6ra may also be used in the future to treat chronic inflammatory bowel disease, neurodegenerative diseases, and cancer.

Customer Reviews (3)

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Reviews
12/08/2021

    It has good effect and stability in gene expression regulation.

    05/31/2020

      Will not interact with other drugs, will not affect.

      04/12/2019

        The application performance is stable in common colorimetric reactions.

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