Active Recombinant Human IMPDH1 Protein, His-Tagged

• Cat.No.: IMPDH1-01H
• Product Overview: Recombinant Human IMPDH1 Protein, His-Tagged was expressed in sf21 cell

Specification

• Species: Human
• Source: Sf21 Cells
• Tag: His
• Description: The protein encoded by this gene acts as a homotetramer to regulate cell growth. The encoded protein is an enzyme that catalyzes the synthesis of xanthine monophosphate (XMP) from inosine-5'-monophosphate (IMP). This is the rate-limiting step in the de novo synthesis of guanine nucleotides. Defects in this gene are a cause of retinitis pigmentosa type 10 (RP10). Several transcript variants encoding different isoforms have been found for this gene.
• Bio-activity: Measured by its ability to convert the substrate inosine-5'-phosphate (IMP) to xanthosine-5'-phosphate (XMP). The specific activity is >100 pmol/min/μg, as measured under the described conditions.
• Molecular Mass: 61 kDa
• N-terminal Sequence Analysis: Met
• Endotoxin: <1.0 EU per 1 μg of the protein by the LAL method.
• Purity: >90%, by SDS-PAGE visualized with Silver Staining and quantitative densitometry by Coomassie® Blue Staining.
• Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  6 months from date of receipt, -20 to -70 °C as supplied.
  3 months, -20 to -70 °C under sterile conditions after opening.
• Storage Buffer: Supplied as a 0.2 μm filtered solution in Tris, NaCl, EDTA, Glycerol and TCEP.
• Shipping: The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Gene Information

• Gene Name: IMPDH1 inosine monophosphate dehydrogenase 1 [ Homo sapiens (human) ]
• Official Symbol: IMPDH1
• Synonyms: DKFZp781N0678, EC 1.1.1.205, IMP (inosine 5'-monophosphate) dehydrogenase 1, IMP (inosine monophosphate) dehydrogenase 1, IMP Dehydrogenase 1, IMPD, IMPD 1, IMPD1, IMPDH 1, IMPDH-I, IMPDH1, LCA11, LCA11RP10, RP10, inosine-5'-monophosphate dehydrogenase 1, retinitis pigmentosa 10 (autosomal dominant), sWSS2608
• Gene ID: 3614
• mRNA Refseq: NM_000883.4
• Protein Refseq: NP_899066
• MIM: 146690
• UniProt ID: P20839