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Official Full Name interferon regulatory factor 6
Background This gene encodes a member of the interferon regulatory transcription factor (IRF) family. Family members share a highly-conserved N-terminal helix-turn-helix DNA-binding domain and a less conserved C-terminal protein-binding domain. The encoded protein may be a transcriptional activator. Mutations in this gene can cause van der Woude syndrome and popliteal pterygium syndrome. Mutations in this gene are also associated with non-syndromic orofacial cleft type 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2011]
Synonyms IRF6; interferon regulatory factor 6; LPS; PIT; PPS; VWS; OFC6; PPS1; VWS1;
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IRF6-2017H Recombinant Human IRF6 protein, His & T7-tagged E.coli His/T7
    Human IRF6-28727TH Recombinant Human IRF6 Wheat Germ N/A
    Human IRF6-5001H Recombinant Human IRF6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human IRF6-5035H Recombinant Human IRF6 Protein, GST-tagged Wheat Germ GST
    Human IRF6-5161HCL Recombinant Human IRF6 293 Cell Lysate HEK293 N/A
    Mouse Irf6-2018M Recombinant Mouse Irf6 protein, His & T7-tagged E.coli His/T7
    Mouse Irf6-3577M Recombinant Mouse Irf6 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse IRF6-8304M Recombinant Mouse IRF6 Protein Mammalian Cell His
    Rhesus Macaque IRF6-2299R Recombinant Rhesus monkey IRF6 Protein, His-tagged Mammalian Cell His
    Zebrafish IRF6-10876Z Recombinant Zebrafish IRF6 Mammalian Cell His

    irf6 involved in several pathways and played different roles in them. We selected most pathways irf6 participated on our site, such as Apoptosis, Cytokine Signaling in Immune system, Immune System, which may be useful for your reference. Also, other proteins which involved in the same pathway with irf6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system KLB; DUSP4; TAB1; TRIM46; XAF1; RASGRP1; DAB2IPB; GBP5; CSF2RA; IRF9
    Immune System ISG20; CXADR; BTR02; KIF22; EDARADD; TNFRSF13C; KIF11; PIK3AP1; BLMH; SH3RF1
    Interferon Signaling EIF4G2; ARIH1L; ARIH1; ADAR; TRIM48; IFIT2; USP18; IFI30; TRIM46; IFI6
    Interferon alpha/beta signaling GBP2; IRF2; IRF4; IFIT3; IFI27; IFITM2; MX2; SAMHD1; BST2; IFI35
    Interferon gamma signaling TRIM48; TRIM26; TRIM68; TRIM14; TRIM5; TRIM17; FCGR1B; OASL; IRF6; TRIM62

    irf6 has several biochemical functions, for example, DNA binding, protein binding, regulatory region DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by irf6 itself. We selected most functions irf6 had, and list some proteins which have the same functions with irf6. You can find most of the proteins on our site.

    Function Related Protein
    protein binding NUP205; IRAK4; CLCF1; PICALM; PSMB9; KIF20B; AP2A1; TPD52; LYVE1; MEP1A
    regulatory region DNA binding HMGA2; IRF4A; IRF3; IRF8; IRF6; IRF1A; IRF1B; NFKB1; IRF2A; IRF5
    transcription factor activity, sequence-specific DNA binding UBN2B; USF2; ZNF83; RUNX2; ZNF12; CREB3L3L; EGR1; KLF4; E2F2; PA2G4A

    irf6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with irf6 here. Most of them are supplied by our site. Hope this information will be useful for your research of irf6.

    IRF8; IRF5; BNC2

    Koelsch, KA; Webb, R; et al. Functional characterization of the MECP2/IRAK1 lupus risk haplotype in human T cells and a human MECP2 transgenic mouse. JOURNAL OF AUTOIMMUNITY 41:168-174(2013).

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