IRF9

  • Official Full Name

    interferon regulatory factor 9

  • Overview

    Transcription regulatory factor that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.
  • Synonyms

    IRF9; interferon regulatory factor 9; interferon stimulated transcription factor 3, gamma (48kD) , interferon stimulated transcription factor 3, gamma 48kDa , ISGF3G; ISGF-3 gamma; ISGF3 p48 subunit; interferon-stimulated gene factor 3 gamma; transcripti;

  • Cell & Tissue Lysates
  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IRF9-5158HCL Recombinant Human IRF9 293 Cell Lysate HEK293 N/A
Human IRF9-2337H Recombinant Human IRF9 Protein, His-tagged E.coli N-His Met1-Val393
Human IRF9-1758HFL Recombinant Full Length Human IRF9 Protein, C-Flag-tagged Mammalian cells Flag
Human IRF9-5016H Recombinant Human IRF9 Protein, GST-tagged Wheat Germ GST
Human IRF9-3413H Recombinant Human IRF9 Protein (Met1-Val393), His tagged E.coli His Met1-Val393
Human IRF9-1202H Recombinant Human IRF9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human IRF9-3631H Recombinant Human IRF9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human IRF9-5763HF Recombinant Full Length Human IRF9 Protein, GST-tagged In Vitro Cell Free System GST 393 amino acids
Human IRF9-1202H-B Recombinant Human IRF9 Protein Pre-coupled Magnetic Beads HEK293
Mouse Irf9-3586M Recombinant Mouse Irf9 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Cynomolgus Monkey IRF9-630C Recombinant Cynomolgus IRF9 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey IRF9-376C Recombinant Cynomolgus Monkey IRF9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey IRF9-376C-B Recombinant Cynomolgus Monkey IRF9 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IRF9-2302R Recombinant Rhesus monkey IRF9 Protein, His-tagged Mammalian Cell His
Rhesus Macaque IRF9-2123R-B Recombinant Rhesus Macaque IRF9 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IRF9-2123R Recombinant Rhesus Macaque IRF9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish IRF9-11731Z Recombinant Zebrafish IRF9 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • IRF9 Related Signal Pathway

IRF9 involved in several pathways and played different roles in them. We selected most pathways IRF9 participated on our site, such as Cytokine Signaling in Immune system, Hepatitis C, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with IRF9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine Signaling in Immune systemEIF4G1;FGFR1B;SPRED2;SPNA1;TNFRSF13C;PHB;GBP1;FRS2;NUP35
Hepatitis CMAPK9;DDX58;CLDN1;CLDN3;Ifna11;MAPK13;RNASEL;IFNA1;PPP2CB
Herpes simplex infectionIL15;TAF6L;RELA;H2-AB1;IFNA4;FAS;IL6;IRF3;TLR3
IFN-gamma pathwayIRF9;DAPK1
Immune SystemKIF26A;AF251705;IGHM;KIF3C;IFIT3;TLR10;LAIR2;POLR3H;TRIM56
Influenza AIFNA21;MAP2K2;HLA-DMA;AKT2;IFNB1;MAPK12;TYK2;CYCS;NXT2
Interferon SignalingIRF4;BST2;IFI6;ADAR;FCGR1B;TRIM10;TRIM5;USP18;EIF4E3
Interferon alpha/beta signalingIFIT2;IFIT3;MX2;IFI35;USP18;ISG20;IFI6;GBP2;BST2

IRF9 has several biochemical functions, for example, core promoter binding, protein binding, transcription factor activity, sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IRF9 itself. We selected most functions IRF9 had, and list some proteins which have the same functions with IRF9. You can find most of the proteins on our site.

Function Related Protein
core promoter bindingSFPQ;DHX36;E2F7;E2F8;PSPC1;HDAC4;INSM1A;INSM1B;ARNTL
protein bindingRPL28;WNT3;ARMCX1;DYNAP;ADAM22;RPS6KB1;UQCC2;STAP2;TLX1
transcription factor activity, sequence-specific DNA bindingNFAT5A;FOXD1;ESR2;NR2F6;ZNF202;TEAD3B;SREBF1;CREBBP;PIP4K2AA

IRF9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IRF9 here. Most of them are supplied by our site. Hope this information will be useful for your research of IRF9.

STAT2; IFNAR2; STAT1; MYO1F; uvrA; S100A13; pi3p

Research Area

Related articles

Erb, HHH; Langlechner, RV; et al. IL6 sensitizes prostate cancer to the antiproliferative effect of IFN alpha(2) through IRF9. ENDOCRINE-RELATED CANCER 20:677-689(2013).
Colonne, PM; Sahni, A; et al. Suppressor of cytokine signalling protein SOCS1 and UBP43 regulate the expression of type I interferon-stimulated genes in human microvascular endothelial cells infected with Rickettsia conorii. JOURNAL OF MEDICAL MICROBIOLOGY 62:968-979(2013).
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