ISG15

  • Official Full Name

    ISG15 ubiquitin-like modifier

  • Overview

    The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
  • Synonyms

    ISG15; ISG15 ubiquitin-like modifier; G1P2; IP17; UCRP; IFI15; hUCRP; ubiquitin-like protein ISG15; ubiquitin cross-reactive protein; interferon-stimulated protein, 15 kDa; interferon-induced 17-kDa/15-kDa protein; interferon, alpha-inducible protein (clone IFI-15K);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Bovine
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • 6×His
  • Calmodulin
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His|GFP
  • Myc
  • DDK
  • MYC
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human ISG15-28645TH Recombinant Human ISG15 E.coli N/A 157 amino acids
Human ISG15-29H Recombinant Human ISG15 Ubiquitin-Like Modifier, Calmodulin-Tagged E.coli Calmodulin
Human ISG15-191H Recombinant Human ISG15 protein(Met1-Gly157) E. coli N/A Met1-Gly157
Human ISG15-28728TH Recombinant Human ISG15 E.coli N/A
Human ISG15-551H Recombinant Human ISG15 Protein, His-tagged E.coli His
Human Isg15-83H Recombinant Human Isg15 protein E.coli N/A Met1-Ser165
Human ISG15-242H Recombinant Human ISG15 Mammalian Cell His
Human ISG15-258H Recombinant Human ISG15, StrepII-tagged Human Cell Strep II 2-157, 156 a.a.
Human ISG15-61H Recombinant Human ISG15 protein, His-tagged E.coli His 180aa(including fusion tag)
Human ISG15-5152HCL Recombinant Human ISG15 293 Cell Lysate HEK293 N/A
Human ISG15-1002H Recombinant Human ISG15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human ISG15-5101HF Recombinant Full Length Human ISG15 Protein, GST-tagged In Vitro Cell Free System GST 165 amino acids
Human Isg15-3120H Recombinant Human Isg15 protein, GST-tagged E.coli GST 2-157aa
Human ISG15-1203H Recombinant Human ISG15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human ISG15-3422H Recombinant Human ISG15 protein, His-tagged E.coli His 1-165 aa
Human ISG15-1203H-B Recombinant Human ISG15 Protein Pre-coupled Magnetic Beads HEK293
Human ISG15-931HFL Recombinant Full Length Human ISG15 Protein, C-Flag-tagged Mammalian cells Flag
Human ISG15-11H Active Recombinant Human ISG15 Protein (Met1-Gly156, C78S, G157C), C-6×His tagged E.coli C-6×His Met1-Gly156
Human ISG15-2606H Recombinant Human ISG15 protein E.coli N/A Gly2-Gly157
Human ISG15-3330H Recombinant Human ISG15 Protein (Met1-Gly157), N-His tagged E.coli N-His Met1-Gly157
Human ISG15-3329H Recombinant Human ISG15 Protein (Gly2-Gly157), C-His tagged E.coli C-His Gly2-Gly157
Human ISG15-12H Recombinant Human ISG15 Protein (2-157), Rhodamine 110 Labeled E.coli 2-157
Human ISG15-4606H Recombinant Human ISG15 Protein, GST-tagged Wheat Germ GST
Human ISG15-987H Active Recombinant Human ISG15 Protein, GST-tagged E.coli GST 1-165 aa
Human ISG15-4333H Recombinant Human ISG15 protein, His-tagged Yeast His 2-157aa
Mouse Isg15-009M Recombinant Mouse Isg15 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Isg15-40M Recombinant Mouse Isg15 Protein, His-tagged E. coli His Ala2~Ala161
Mouse ISG15-431M Recombinant Mouse ISG15 Protein, His-GFP-tagged E.coli His/GFP
Bovine ISG15-3119B Recombinant Bovine ISG15 protein, His-tagged E.coli His 1-154aa
Rhesus Macaque ISG15-2306R Recombinant Rhesus monkey ISG15 Protein, His-tagged Mammalian Cell His
Rhesus Macaque ISG15-2127R Recombinant Rhesus Macaque ISG15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque ISG15-2127R-B Recombinant Rhesus Macaque ISG15 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish ISG15-8009Z Recombinant Zebrafish ISG15 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • ISG15 Related Articles
  • ISG15 Related Research Area

ISG15 involved in several pathways and played different roles in them. We selected most pathways ISG15 participated on our site, such as RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ISG15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
RIG-I-like receptor signaling pathwayRIPK1L;FADD;IKBKB;TRADD;RNF125;PIN1;RNF207B;MAP3K7;DDX3

ISG15 has several biochemical functions, for example, protein binding, protein tag. Some of the functions are cooperated with other proteins, some of the functions could acted by ISG15 itself. We selected most functions ISG15 had, and list some proteins which have the same functions with ISG15. You can find most of the proteins on our site.

Function Related Protein
protein bindingPLEKHA2;DMAP1;IGSF8;SEMA7A;ACTL6A;SULT1E1;TMEM100;PTCRA;HP1BP3
protein tagSUMO1;SUMO3;SUMO2;SUMO3A;SUMO3B;NFATC2IP;SUMO2B;UBL5;SUMO4

ISG15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISG15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ISG15.

UBA7; USP18; FLNB; PPM1B; ELF3

Baez-Santos, YM; St John, SE; et al. The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds. ANTIVIRAL RESEARCH 115:21-38(2015).
Feng, XB; Huang, J; et al. Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus. CLINICAL RHEUMATOLOGY 34:71-79(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any therapeutic applications of ISG15 in viral infections? 05/12/2020

ISG15 has been investigated as a potential therapeutic target for developing antiviral drugs.

Are there potential therapeutic strategies involving ISG15 for neurodegenerative diseases? 04/14/2020

Scientists are exploring ISG15-related pathways as potential therapeutic targets for neurodegenerative disease treatment.

How is ISG15 clinically relevant in the context of viral infections? 05/30/2019

ISG15 is used as a biomarker to monitor and diagnose viral infections, such as influenza, HIV, and SARS-CoV-2.

How is ISG15 involved in autoimmune diseases? 07/23/2018

Dysregulation of ISG15 has been linked to autoimmune diseases like systemic lupus erythematosus (SLE).

Can ISG15 be used to predict the severity of viral infections? 04/17/2017

Yes, elevated levels of ISG15 in the blood can indicate a more severe viral infection.

Customer Reviews (3)

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Reviews
01/27/2020

    The manufacturer's support has played a vital role in my work, providing expert guidance and troubleshooting assistance whenever needed.

    04/03/2018

      It has been extensively utilized in protein electron microscopy structure analysis, yielding exceptional outcomes.

      12/07/2017

        I am grateful for their dedication and commitment to ensuring the success of my experiments.

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