ISG15 Protein


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Official Full Name ISG15 ubiquitin-like modifier
Background The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
Synonyms ISG15; ISG15 ubiquitin-like modifier; G1P2; IP17; UCRP; IFI15; hUCRP; ubiquitin-like protein ISG15; ubiquitin cross-reactive protein; interferon-stimulated protein, 15 kDa; interferon-induced 17-kDa/15-kDa protein; interferon, alpha-inducible protein (clone IFI-15K);
    • Species :
    • Bovine
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Calmodulin
    • GST
    • His
    • GFP
    • MYC/DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ISG15-191H Recombinant Human ISG15 E.coli N/A
    Human ISG15-987H Recombinant Human ISG15 Protein, GST-tagged E.coli GST
    Human ISG15-242H Recombinant Human ISG15 Mammalian Cell His
    Human ISG15-258H Recombinant Human ISG15, StrepII-tagged Human Cell Strep II
    Human ISG15-28645TH Recombinant Human ISG15 E.coli N/A
    Human ISG15-28728TH Recombinant Human ISG15 E.coli N/A
    Human ISG15-29H Recombinant Human ISG15 Ubiquitin-Like Modifier, Calmodulin-Tagged E.coli Calmodulin
    Human ISG15-551H Recombinant Human ISG15 Protein, His-tagged E.coli His
    Human ISG15-61H Recombinant Human ISG15 protein, His-tagged E.coli His
    Human Isg15-83H Recombinant Human Isg15, None tagged E.coli N/A
    Rhesus Macaque ISG15-2306R Recombinant Rhesus monkey ISG15 Protein, His-tagged Mammalian Cell His
    Zebrafish ISG15-8009Z Recombinant Zebrafish ISG15 Mammalian Cell His
    Human ISG15-5152HCL Recombinant Human ISG15 293 Cell Lysate HEK293 N/A
    Mouse Isg15-40M Recombinant Mouse Isg15 Protein, His-tagged E. coli His
    Bovine ISG15-3119B Recombinant Bovine ISG15 protein, His-tagged E.coli His
    Human Isg15-3120H Recombinant Human Isg15 protein, GST-tagged E.coli GST
    Human ISG15-3422H Recombinant Human ISG15 protein, His-tagged E.coli His
    Human ISG15-4333H Recombinant Human ISG15 protein, His-tagged Yeast His
    Human ISG15-5101HF Recombinant Full Length Human ISG15 Protein, GST-tagged In Vitro Cell Free System GST
    Human ISG15-1002H Recombinant Human ISG15 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ISG15-4606H Recombinant Human ISG15 Protein, GST-tagged Wheat Germ GST
    Mouse Isg15-009M Recombinant Mouse Isg15 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Mouse Isg15-1868M Recombinant Mouse Isg15 protein, His-tagged E.coli His
    Mouse ISG15-431M Recombinant Mouse ISG15 Protein, His-GFP-tagged E.coli His/GFP

    ISG15 involved in several pathways and played different roles in them. We selected most pathways ISG15 participated on our site, such as RIG-I-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with ISG15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    RIG-I-like receptor signaling pathway MAVS; NFKBIB; TRIM25; TMEM173; MAPK12B; NFKBIA; IFNB; IFNA13; CASP8; RELA

    ISG15 has several biochemical functions, for example, protein binding, protein tag. Some of the functions are cooperated with other proteins, some of the functions could acted by ISG15 itself. We selected most functions ISG15 had, and list some proteins which have the same functions with ISG15. You can find most of the proteins on our site.

    Function Related Protein
    protein binding TJP1; BCLAF1; SH2B3; HNRNPA1; UBA7; EIF2A; SELE; TESC; RAB38; RAC3
    protein tag SUMO3; SUMO1; SUMO3A; SUMO3B; SUMO2B; SUMO2; UBL5; RNF41; NFATC2IP; SUMO4

    ISG15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ISG15 here. Most of them are supplied by our site. Hope this information will be useful for your research of ISG15.

    UBA7; USP18; FLNB; PPM1B; ELF3

    Baez-Santos, YM; St John, SE; et al. The SARS-coronavirus papain-like protease: Structure, function and inhibition by designed antiviral compounds. ANTIVIRAL RESEARCH 115:21-38(2015).
    Feng, XB; Huang, J; et al. Identification of interferon-inducible genes as diagnostic biomarker for systemic lupus erythematosus. CLINICAL RHEUMATOLOGY 34:71-79(2015).

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