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Recombinant Human ISG15 Protein, His-tagged

Cat.No. : ISG15-551H
Product Overview : Recombinant Human ISG15 fused with His tag at C-terminal was expressed in E. coli.
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Description : The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted.
Source : E. coli
Tag : His
Form : Supplied as a 0.2 µM filtered solution of 50mM HEPES, 100mM NaCl, pH 8.0
Molecular Mass : 18.2kD
AA Sequence : MGWDLTVKMLAGNEFQVSLSSSMSV SELKAQITQKIGVHAFQQRLAVHPS GVALQDRVPLASQGLGPGSTVLLVV DKCDEPLNILVRNNKGRSSTYEVRL TQTVAHLKQQVSGLEGVQDDLFWLT FEGKPLEDQLPLGEYGLKPLSTVFM NLRLRGGLEHHHHHH
Endotoxin : Endotoxin level is <0.1 ng/µg of protein (<1EU/µg).
Purity : >95% as determined by SDS-PAGE and Coomassie blue staining
Gene Name : ISG15 ISG15 ubiquitin-like modifier [ Homo sapiens ]
Official Symbol : ISG15
Synonyms : ISG15; ISG15 ubiquitin-like modifier; G1P2, interferon, alpha inducible protein (clone IFI 15K); ubiquitin-like protein ISG15; IFI15; UCRP; ubiquitin cross-reactive protein; interferon-induced 15 kDa protein; interferon-induced 17 kDa protein; interferon-stimulated protein, 15 kDa; interferon-induced 17-kDa/15-kDa protein; interferon, alpha-inducible protein (clone IFI-15K); G1P2; IP17; hUCRP;
Gene ID : 9636
mRNA Refseq : NM_005101
Protein Refseq : NP_005092
MIM : 147571
UniProt ID : P05161

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any therapeutic applications of ISG15 in viral infections? 05/12/2020

ISG15 has been investigated as a potential therapeutic target for developing antiviral drugs.

Are there potential therapeutic strategies involving ISG15 for neurodegenerative diseases? 04/14/2020

Scientists are exploring ISG15-related pathways as potential therapeutic targets for neurodegenerative disease treatment.

How is ISG15 clinically relevant in the context of viral infections? 05/30/2019

ISG15 is used as a biomarker to monitor and diagnose viral infections, such as influenza, HIV, and SARS-CoV-2.

How is ISG15 involved in autoimmune diseases? 07/23/2018

Dysregulation of ISG15 has been linked to autoimmune diseases like systemic lupus erythematosus (SLE).

Can ISG15 be used to predict the severity of viral infections? 04/17/2017

Yes, elevated levels of ISG15 in the blood can indicate a more severe viral infection.

Customer Reviews (3)

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Reviews
01/27/2020

    The manufacturer's support has played a vital role in my work, providing expert guidance and troubleshooting assistance whenever needed.

    04/03/2018

      It has been extensively utilized in protein electron microscopy structure analysis, yielding exceptional outcomes.

      12/07/2017

        I am grateful for their dedication and commitment to ensuring the success of my experiments.

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