ITGA7
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Official Full Name
integrin, alpha 7
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Overview
The protein encoded by this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. They mediate a wide spectrum of cell-cell and cell-matrix interactions, and thus play a role in cell migration, morphologic development, differentiation, and metastasis. This protein functions as a receptor for the basement membrane protein laminin-1. It is mainly expressed in skeletal and cardiac muscles and may be involved in differentiation and migration processes during myogenesis. Defects in this gene are associated with congenital myopathy. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. -
Synonyms
[a]7; alpha7; ITGA7; integrin, alpha 7; integrin alpha-7;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Rat
- E.coli
- HEK293
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | ITGA7-28842TH | Recombinant Human ITGA7 | Wheat Germ | Non | 100 amino acids |
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| Human | ITGA7-4994H | Recombinant Human ITGA7 Protein, GST-tagged | Wheat Germ | GST |
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| Human | ITGA7-4995H | Recombinant Human ITGA7 Protein, His-tagged | E.coli | His | Arg648~Ser952 |
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| Rat | ITGA7-3112R | Recombinant Rat ITGA7 Protein | Mammalian Cell | His |
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| Rat | ITGA7-2768R | Recombinant Rat ITGA7 Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | ITGA7-2768R-B | Recombinant Rat ITGA7 Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
ITGA7 involved in several pathways and played different roles in them. We selected most pathways ITGA7 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with ITGA7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | SYK;PPP2CB;STK11;IL3RA;PPP2CA;TLR2;IFNA13;ANGPT1;IL7R |
| Focal adhesion | HRASA;DIAPH1;FN1;PIK3CB;PDGFB;TLN1;COL11A1A;MYL12B;COL4A2 |
| ECM-receptor interaction | COL27A1;HMMR;ITGA8;SPP1;THBS4B;COL27A1A;COL1A1B;COL2A1;COL2A1A |
| Regulation of actin cytoskeleton | MYH9;SSH2;GSNA;CDC42L;PPP1CA;MYLK3;ABI2B;PPP1CAA;SSH1 |
| Hypertrophic cardiomyopathy (HCM) | TPM3;CACNA2D1;TGFB3;ITGA9;CACNB1;MYBPC3;MYL3;CACNG6;DMD |
| Arrhythmogenic right ventricular cardiomyopathy (ARVC) | SGCB;CACNG4;CDH2;ACTN3;EMD;ITGB3;ATP2A2;DSG2;TCF7L2 |
| Dilated cardiomyopathy | TPM4;CACNG6;DES;ITGB5;TGFB2;ITGA9;CACNA2D3;SGCB;TGFB1 |
ITGA7 has several biochemical functions, for example, laminin binding, metal ion binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by ITGA7 itself. We selected most functions ITGA7 had, and list some proteins which have the same functions with ITGA7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| laminin binding | LYPD5;TINAGL1;ITGA7;NCL;PLEKHA2;ECM1;LGALS3;CTSS;LYPD3 |
| metal ion binding | ZNF530;ASAP1;PRKCDA;ANKZF1;GUCA1E;TRIM30A;PAPD4;CPD;ZFP36 |
| protein binding | CXCR5;EZR;DHH;RBBP4;KRTAP5-6;PRKD1;IRF3;SNRPB2;REXO1L1 |
ITGA7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ITGA7 here. Most of them are supplied by our site. Hope this information will be useful for your research of ITGA7.
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