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Official Full Name integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1
Background ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); CD11A; LFA-1; LFA1A; integrin alpha-L; LFA-1A; LFA-1 alpha; integrin gene promoter; CD11 antigen-like family member A; lymphocyte function-associated antigen 1; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide;
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cells
    • Yeast
    • Tag :
    • His
    • Avi
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human ITGAL-151H Recombinant Human ITGAL Protein, His-tagged Human Cells His
    Human ITGAL & ITGB2-7130H Recombinant Human ITGAL & ITGB2 Protein, His-Avi-tagged, Biotinylated HEK293 His/Avi
    Human ITGAL-2092H Recombinant Human ITGAL Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human ITGAL-5129HCL Recombinant Human ITGAL 293 Cell Lysate HEK293 N/A
    Human ITGAL-7134H Recombinant Human ITGAL protein, His & T7-tagged E.coli His/T7
    Mouse ITGAL-1426M Recombinant Mouse ITGAL Protein (153-325 aa), His-tagged Yeast His
    Mouse Itgal-3601M Recombinant Mouse Itgal Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse ITGAL-589M Recombinant Mouse ITGAL Protein (153-325 aa), His-tagged E.coli His
    Rat Itgal-7135R Recombinant Rat Itgal protein, His & T7-tagged E.coli His/T7

    itgal involved in several pathways and played different roles in them. We selected most pathways itgal participated on our site, such as Rap signaling pathway, Cell adhesion molecules (CAMs), Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with itgal were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Rap signaling pathway KLK1B4; PLCE1; FGF3; FGFR4; LPAR3; NRAS; PFN1; GRIN1; RAC1; HRAS
    Cell adhesion molecules (CAMs) CLDNF; CNTN1A; HLA-A; LRRC4; PTPRC; CDH2; JAM2A; CDH15; CLDN7A; VCAM1
    Natural killer cell mediated cytotoxicity RAET1G; PRF1; PIK3R3; KLRC3; IFNA16; NRAS; IFNA13; VAV3; PPP3CB; NCR1
    Leukocyte transendothelial migration PECAM1; CDC42; NCF4; CLDN17; ITGB2; PIK3R2; CXCR4; ITGAL; JAM2; CLDN11
    Regulation of actin cytoskeleton ITGA3; FGF6B; FGF4; FN1; ACTN4; DIAPH1; RHOAD; BAIAP2A; RHOAC; FGF17
    Malaria HBB; SDC2; DARC; GYPC; MET; TLR9; IL6; HBA1; TGFB1; ITGB2
    Staphylococcus aureus infection FPR1; PTAFR; C1RA; C4A; FCGR1; C1QB; FCGR2C; HLA-DOA; HLA-DMA; ITGB2L
    HTLV-I infection TGFB2; BAX; IL6; WNT5A; IKBKB; SPI1; CDC16; BCL2L1; ANAPC1; POLE3
    Epstein-Barr virus infection PSMD4; MAPK10; FGR; HLA-DRA; HLA-DRB1; PSMD11; LYN; VIM; PSMD13; POLR2D
    Rheumatoid arthritis CXCL6; IFNG; HLA-DRA; GM-CSF; ITGB2L; TNFSF13B; Il23a; Il12b; ATP6V1H; ATP6V0D1; CD80
    Viral myocarditis CD80; SGCB; CD86; CD40LG; LAMA2; SGCD; HLA-DQB1; HLA-DOB; CD40; ICAM1

    itgal has several biochemical functions, for example, ICAM-3 receptor activity, cell adhesion molecule binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by itgal itself. We selected most functions itgal had, and list some proteins which have the same functions with itgal. You can find most of the proteins on our site.

    Function Related Protein
    ICAM-3 receptor activity CLEC4M; ITGAL; ITGB2
    cell adhesion molecule binding GRIN2A; PVRL1; PVR; CD226; CAML; NLGN3; CADM1A; LPHN1; PTBP3; NRXN2
    metal ion binding TIMP3; ZBTB8B; FTR43; POLA1; TSSK1; NENF; ZNF384L; NME2; FAM170A; RXRGA
    protein binding TAX1BP1; DZIP1; SRPK1; KPNA6; DDX3X; SLC3A1; HIST2H3C2; CERK; OPRK1; ARID3B

    itgal has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with itgal here. Most of them are supplied by our site. Hope this information will be useful for your research of itgal.

    PTPRC; q9wmx2-pro_0000037551; env; ICAM1; ICAM3; VHL; Rassf5; RANBP9; MYC

    Blanco, FJ; Ojeda-Fernandez, L; et al. Genome-Wide Transcriptional and Functional Analysis of Endoglin Isoforms in the Human Promonocytic Cell Line U937. JOURNAL OF CELLULAR PHYSIOLOGY 230:947-958(2015).
    Williams, AS; Kang, L; et al. Integrin alpha 1-null Mice Exhibit Improved Fatty Liver When Fed a High Fat Diet Despite Severe Hepatic Insulin Resistance. JOURNAL OF BIOLOGICAL CHEMISTRY 290:6546-6557(2015).

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