| Official Full Name | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1 |
| Background | ITGAL encodes the integrin alpha L chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form the integrin lymphocyte function-associated antigen-1 (LFA-1), which is expressed on all leukocytes. LFA-1 plays a central role in leukocyte intercellular adhesion through interactions with its ligands, ICAMs 1-3 (intercellular adhesion molecules 1 through 3), and also functions in lymphocyte costimulatory signaling. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Synonyms | ITGAL; integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide); CD11A; LFA-1; LFA1A; integrin alpha-L; LFA-1A; LFA-1 alpha; integrin gene promoter; CD11 antigen-like family member A; lymphocyte function-associated antigen 1; leukocyte adhesion glycoprotein LFA-1 alpha chain; leukocyte function-associated molecule 1 alpha chain; antigen CD11A (p180), lymphocyte function-associated antigen 1, alpha polypeptide; |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
itgal involved in several pathways and played different roles in them. We selected most pathways itgal participated on our site, such as Rap signaling pathway, Cell adhesion molecules (CAMs), Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with itgal were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Rap signaling pathway | KLK1B4; PLCE1; FGF3; FGFR4; LPAR3; NRAS; PFN1; GRIN1; RAC1; HRAS |
| Cell adhesion molecules (CAMs) | CLDNF; CNTN1A; HLA-A; LRRC4; PTPRC; CDH2; JAM2A; CDH15; CLDN7A; VCAM1 |
| Natural killer cell mediated cytotoxicity | RAET1G; PRF1; PIK3R3; KLRC3; IFNA16; NRAS; IFNA13; VAV3; PPP3CB; NCR1 |
| Leukocyte transendothelial migration | PECAM1; CDC42; NCF4; CLDN17; ITGB2; PIK3R2; CXCR4; ITGAL; JAM2; CLDN11 |
| Regulation of actin cytoskeleton | ITGA3; FGF6B; FGF4; FN1; ACTN4; DIAPH1; RHOAD; BAIAP2A; RHOAC; FGF17 |
| Malaria | HBB; SDC2; DARC; GYPC; MET; TLR9; IL6; HBA1; TGFB1; ITGB2 |
| Staphylococcus aureus infection | FPR1; PTAFR; C1RA; C4A; FCGR1; C1QB; FCGR2C; HLA-DOA; HLA-DMA; ITGB2L |
| HTLV-I infection | TGFB2; BAX; IL6; WNT5A; IKBKB; SPI1; CDC16; BCL2L1; ANAPC1; POLE3 |
| Epstein-Barr virus infection | PSMD4; MAPK10; FGR; HLA-DRA; HLA-DRB1; PSMD11; LYN; VIM; PSMD13; POLR2D |
| Rheumatoid arthritis | CXCL6; IFNG; HLA-DRA; GM-CSF; ITGB2L; TNFSF13B; Il23a; Il12b; ATP6V1H; ATP6V0D1; CD80 |
| Viral myocarditis | CD80; SGCB; CD86; CD40LG; LAMA2; SGCD; HLA-DQB1; HLA-DOB; CD40; ICAM1 |
itgal has several biochemical functions, for example, ICAM-3 receptor activity, cell adhesion molecule binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by itgal itself. We selected most functions itgal had, and list some proteins which have the same functions with itgal. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ICAM-3 receptor activity | CLEC4M; ITGAL; ITGB2 |
| cell adhesion molecule binding | GRIN2A; PVRL1; PVR; CD226; CAML; NLGN3; CADM1A; LPHN1; PTBP3; NRXN2 |
| metal ion binding | TIMP3; ZBTB8B; FTR43; POLA1; TSSK1; NENF; ZNF384L; NME2; FAM170A; RXRGA |
| protein binding | TAX1BP1; DZIP1; SRPK1; KPNA6; DDX3X; SLC3A1; HIST2H3C2; CERK; OPRK1; ARID3B |
itgal has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with itgal here. Most of them are supplied by our site. Hope this information will be useful for your research of itgal.
PTPRC; q9wmx2-pro_0000037551; env; ICAM1; ICAM3; VHL; Rassf5; RANBP9; MYC
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