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Official Full Name integrin, beta 4
Background CD104 is a 205 kD type I transmembrane glycoprotein, known as integrin beta4 chain or beta4 integrin, that associates with integrin alpha6 (CD49f) forms alpha6/beta4 (CD49f/CD104) heterodimer. CD104 is expressed on epithelial cells (especially on the prol
Synonyms ITGB4; integrin, beta 4; integrin beta-4; CD104; GP150; CD104 antigen; integrin beta-4 subunit
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • in vitro E. coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • SUMO
    • T7
    • Myc
    • DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Rat ITGB4-2739R Recombinant Rat ITGB4 Protein (28-713 aa), His-SUMO-tagged in vitro E. coli His/SUMO
    Human ITGB4-181H Recombinant Human ITGB4, GST-tagged E.coli GST
    Human ITGB4-2650H Recombinant Human ITGB4 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ITGB4-4972H Recombinant Human ITGB4 Protein, GST-tagged Wheat Germ GST
    Human ITGB4-6964H Recombinant Human ITGB4 protein, His & T7-tagged E.coli His/T7
    Mouse Itgb4-6965M Recombinant Mouse Itgb4 protein, His & T7-tagged E.coli His/T7
    Rat ITGB4-3116R Recombinant Rat ITGB4 Protein Mammalian Cell His
    Zebrafish ITGB4-2993Z Recombinant Zebrafish ITGB4 Mammalian Cell His

    itgb4 involved in several pathways and played different roles in them. We selected most pathways itgb4 participated on our site, such as PIK-Akt signaling pathway, Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with itgb4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    PIK-Akt signaling pathway PPP2R1A; TP53; CCND1; FGF5; CCND2; IL6R; PCK1; TLR4; Pdgfa&Pdgfb; VEGFB
    Focal adhesion PIK3R3A; KDRL; PRKCB; RAPGEF1; PARVA; TLN1; CDC42L; MAPK6; COL5A2; CAV3
    ECM-receptor interaction COL4A4; THBS3A; LAMC3; LAMA4; LAMB1; COL3A1; COL6A4; COL6A5; ITGB6; COL4A2
    Regulation of actin cytoskeleton BAIAP2A; ITGA5; ITGAE; FGFR4; FGF20B; ACTN4; INSRR; PIK3CB; HRASA; ITGB6
    Hypertrophic cardiomyopathy (HCM) MYL2; ITGA7; SGCD; CACNA2D2; CACNA2D3; CACNG4; CACNG7; SLC8A1; ITGB5; ACE
    Arrhythmogenic right ventricular cardiomyopathy (ARVC) ACTN2; CACNB3; ACTG1; ITGAV; ACTN3; CACNB2; DMD; ITGB6; ITGA9; CTNNA1
    Dilated cardiomyopathy CACNB2; PLN; DMD; ITGA9; ITGA6; ITGA3; ITGA2B; Itga10&Itgb1; TGFB2; CACNG8

    itgb4 has several biochemical functions, for example, G-protein coupled receptor binding, protein binding, receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by itgb4 itself. We selected most functions itgb4 had, and list some proteins which have the same functions with itgb4. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled receptor binding GNAT2; RSPO3; GNA15; POMC; FCN1; AKAP5; HSPA1B; SFTPB; PSAP; DNAJA1
    protein binding STAG2; DCX; WDR11; STAP1; RBFOX1; KRTAP10-8; STK38L; NR1I2; SPINK1; MAL2
    receptor activity NLGN4Y; RNF139; CSF2RB; ADCYAP1R1; CCR6; HTR3A; SLC20A2; NPR2; TNFRSF10B; KRT1

    itgb4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with itgb4 here. Most of them are supplied by our site. Hope this information will be useful for your research of itgb4.

    PLEC; ITGA6; Cadm1; S1PR3; ARRDC3

    Chen, YH; Chang, SH; et al. The mechanism for keratinocyte detaching from pH-responsive chitosan. BIOMATERIALS 35:9247-9254(2014).
    Chen, Q; Xu, R; et al. Down-Regulation of Gli Transcription Factor Leads to the Inhibition of Migration and Invasion of Ovarian Cancer Cells via Integrin beta 4-Mediated FAK Signaling. PLOS ONE 9:-(2014).

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