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Official Full Name potassium voltage-gated channel, shaker-related subfamily, member 3
Background Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
Synonyms KCNA3; potassium voltage-gated channel, shaker-related subfamily, member 3; potassium voltage-gated channel subfamily A member 3; HLK3; HPCN3; Kv1.3; MK3; potassium channel 3; type n potassium channel; voltage-gated K(+) channel HuKIII; voltage-gated potassium channel protein Kv1.3; voltage-gated potassium channel subunit Kv1.3; HGK5; PCN3; HUKIII
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KCNA3-29890TH Recombinant Human KCNA3 Wheat Germ N/A
    Mouse KCNA3-8473M Recombinant Mouse KCNA3 Protein Mammalian Cell His
    Rat KCNA3-3166R Recombinant Rat KCNA3 Protein Mammalian Cell His
    Rhesus Macaque KCNA3-2345R Recombinant Rhesus monkey KCNA3 Protein, His-tagged Mammalian Cell His
    Chicken KCNA3-2242C Recombinant Chicken KCNA3 Mammalian Cell His

    kcna3 involved in several pathways and played different roles in them. We selected most pathways kcna3 participated on our site, such as ATF-2 transcription factor network, ATF4 activates genes, ATF6-alpha activates chaperone genes, which may be useful for your reference. Also, other proteins which involved in the same pathway with kcna3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ATF-2 transcription factor network JDP2; DDIT3; POU2F1; DUSP1; HRK; JUNB; JUND; JUN; CDK4; RUVBL2
    ATF4 activates genes DCP2; DDIT3; KCNA3; EXOSC8
    ATF6-alpha activates chaperone genes KCNA3; DDIT3
    ATF6-alpha activates chaperones KCNA3; YY2; DDIT3
    MAPK signaling pathway IL1B; CACNA2D4; PDGFB; MAP3K2; AKT2L; JIP1; MRAS; ARRB2A; CASP3A; PDGFRA
    Metabolism of proteins ADAMTS15; C8orf84; MBOAT4; DNAJB9; IGFBP5B; CDX2; CGB5; ARL2; DPH3; ST6GALNAC1.2
    Non-alcoholic fatty liver disease (NAFLD) NDUFB5; COX6A2; PRKAA1; NDUFA2; LEPR; NFKB1; IL1A; IRS2; NDUFS1; NDUFA1

    kcna3 has several biochemical functions, for example, DNA binding, RNA polymerase II core promoter proximal region sequence-specific DNA binding, cAMP response element binding protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by kcna3 itself. We selected most functions kcna3 had, and list some proteins which have the same functions with kcna3. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding LIG3; ETS1; CEBPA; PML; NFIXB; ZNF157; ZNF574; ZFP30; C1D; MTF1
    RNA polymerase II core promoter proximal region sequence-specific DNA binding NR3C1; SREBF1; E2F8; FLI1; FOSL2; ETV1; NKX6-2; MESP1; SMAD3; ESRRA
    cAMP response element binding protein binding ATF2; CRTC1; CRTC2; CREM; DDIT3; CRTC1A; CRTC3; KCNA3; DAPK3; CREB3
    leucine zipper domain binding KCNA3; MKL1; ATF4; PAWR; NRL; AATF; DAPK3; DDIT3; PMF1; ERC1
    protein binding TRIP6; SPAG9; TCEB3B; MED12; SUPT5H; KLK6; POU1F1; UXT; NRL; CITED2
    protein heterodimerization activity SMAD2; MTTP; NPM1; IRAK3; SRI; RRAGA; BCL2L2; SOX15; F11R.1; MYF6
    NOT protein homodimerization activity MSH3; MSH6; MLXIPL; NUDT16L1; EXT2; KCNA3; DDIT3; MYO9B; MECOM
    transcription corepressor activity CDYL; LHX1; RCOR2; SIRT6; ATF3; SP100; CBFA2T3; ZFPM1; LHX9; YAP1
    transcription factor activity, sequence-specific DNA binding CIR1; SOX4; FOSL1; HOXA2B; KDM3A; RAI1; RUNX2; VDRB; DMRTC1B; SIX2
    transcription factor binding CD34; HDAC9; MDFIC; POU5F1; IGHMBP2; TWIST1; PIK3R1; RB1; RBPJ; MAPK1
    transcription regulatory region DNA binding SMAD7; ARRB1; NR1D1; OVOL2; AIRE; SERPINB1A; REST; CTCF; SOX7; ATMIN
    transcription regulatory region sequence-specific DNA binding NFE2L1B; HDAC1; PITX2; NR5A1A; TFAP2A; BAHD1; NR5A5; NR5A2; MEF2AA; SIN3A
    transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding ALS2CR8; MTF1; MEOX2; TP73; TFAP2C; ZNF750; RFX4; SIX4; EGR2; OTX2

    kcna3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kcna3 here. Most of them are supplied by our site. Hope this information will be useful for your research of kcna3.


    Almilaji, A; Honisch, S; et al. Regulation of the Voltage Gated K+ Channel K-v1.3 by Recombinant Human Klotho Protein. KIDNEY & BLOOD PRESSURE RESEARCH 39:609-622(2014).

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