kcnj11 Protein, potassium inwardly-rectifying channel, subfamily J, member 11


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Official Full Name potassium inwardly-rectifying channel, subfamily J, member 11
Background Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009]
Synonyms KCNJ11; potassium inwardly-rectifying channel, subfamily J, member 11; BIR; HHF2; PHHI; IKATP; TNDM3; KIR6.2; ATP-sensitive inward rectifier potassium channel 11; beta-cell inward rectifier subunit; inward rectifier K(+) channel Kir6.2; inwardly rectifying potassium channel KIR6.2; potassium channel inwardly rectifing subfamily J member 11; potassium channel, inwardly rectifying subfamily J member 11;
    • Species :
    • Human
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.Coli or Yeast
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human KCNJ11-29900TH Recombinant Human KCNJ11 Wheat Germ N/A
    Human KCNJ11-498H Recombinant Human KCNJ11 Mammalian Cell His
    Rat KCNJ11-3196R Recombinant Rat KCNJ11 Protein Mammalian Cell His
    Rat Kcnj11-3756R Recombinant Rat Kcnj11, His-tagged E.Coli or Yeast His
    Rhesus Macaque KCNJ11-2358R Recombinant Rhesus monkey KCNJ11 Protein, His-tagged Mammalian Cell His
    Zebrafish KCNJ11-3666Z Recombinant Zebrafish KCNJ11 Mammalian Cell His

    kcnj11 involved in several pathways and played different roles in them. We selected most pathways kcnj11 participated on our site, such as ABC-family proteins mediated transport, ATP sensitive Potassium channels, FOXA2 and FOXA3 transcription factor networks, which may be useful for your reference. Also, other proteins which involved in the same pathway with kcnj11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ABC-family proteins mediated transport APOA1B; ABCA8; ABCC2; EIF2S1; ABCA7; ABCE1; ABCB8; ABCD3B; ABCF1; KCNJ11
    ATP sensitive Potassium channels KCNJ11; KCNJ8; ABCC9
    FOXA2 and FOXA3 transcription factor networks FOXF1; CPT1A; KCNJ11; DLK1; CPT1C; CPT1B; TTR; CEBPA; FOXA1; UCP2
    Insulin secretion RAPGEF4; ATP1A4; SLC2A1; PRKACG; PLCB2; CCKAR; ATP1B4; RAB3A; ATP1A3; ATP1B1
    Integration of energy metabolism AKAP5; KCNC2; ARL2BP; KCNJ11; SYT5; MARCKSB; GNB5A; GNG13A; GNG13B; MARCKSA
    Inwardly rectifying K+ channels KCNJ14; KCNJ1A.2; KCNJ1A.5; KCNJ1; KCNJ1A.1; GNGT2A; KCNJ1A.4; KCNJ1A.3; ABCC9; KCNJ11
    Metabolism PAOX; GPHNA; CYP2K6; TIAM2; AK7; NDOR1; CTRB1; FIG4; VAPB; FAM96B
    Neuronal System GJA10; KCNH1A; RERG; KCNK13A; BZRAP1; CPLX1; PANX1; CCDC167; KCNV2; RAB3AA

    kcnj11 has several biochemical functions, for example, ATP binding, ATP-activated inward rectifier potassium channel activity, NOT G-protein activated inward rectifier potassium channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by kcnj11 itself. We selected most functions kcnj11 had, and list some proteins which have the same functions with kcnj11. You can find most of the proteins on our site.

    Function Related Protein
    ATP-activated inward rectifier potassium channel activity KCNJ11L; KCNJ1A.2; KCNJ10; KCNJ1B; KCNJ1A.5; KCNJ1A.1; KCNJ1A.6; KCNJ8; KCNJ1A.3; KCNJ1
    NOT G-protein activated inward rectifier potassium channel activity KCNJ11; KCNJ8; KCNJ11L
    ankyrin binding RHBG; RHCG; PTBP3; PLEC; KCTD6; SCN5A; SLC8A1; RHAG; KCNQ2; ATP1A1
    heat shock protein binding BAK1; BCOR; TFAM; BAX; DNAJA3; SSUH2RS1; DNAJA2L; NFKB1; LIMK1; KCNJ11
    ion channel binding PKD1; KCNB2; DLG1; KCNE4; FHL1; SCN5A; NEDD4L; KCNQ1; PIRT; RIMS3
    potassium ion binding ATP1A1; KCNA4; SLC24A5; PDXK; HDAC4; SLC24A2; PKM; PKMB; SLC24A4A; SLC24A1
    protein C-terminus binding HSPG2; MPDZ; PDZD11; CAV3; ERCC3; OPRL1; MRE11A; PPM1A; SIAH1; SNF8
    voltage-gated potassium channel activity KCNC1; HCN2; CNGA3; KCNQ2A; KCNB2; KCNA2B; KCNMA1A; KCNC3B; KCNS3B; KCND2

    kcnj11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kcnj11 here. Most of them are supplied by our site. Hope this information will be useful for your research of kcnj11.

    ABCC9; Kcnj11; ugpC

    Alves, C; Constanca, J; et al. A novel atypical presentation of insulin autoimmune syndrome (Hirata's disease) in a child. JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM 26:1163-1166(2013).
    Irgens, HU; Molnes, J; et al. Prevalence of monogenic diabetes in the population-based Norwegian Childhood Diabetes Registry. DIABETOLOGIA 56:1512-1519(2013).

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