kcnk4 Protein, potassium channel, subfamily K, member 4


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Official Full Name potassium channel, subfamily K, member 4
Background Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids.
Synonyms KCNK4; potassium channel, subfamily K, member 4; potassium channel subfamily K member 4; K2p4.1; TRAAK; MGC144821; K2P4.1 potassium channel; KCNK 4; Potassium inwardly rectifying channel subfamily K member 4; TRAAK1; TRAAKt; TWIK related arachidonic acid stimulated potassium channel protein; Two pore K+ channel KT4.1; two pore K(+) channel KT4.1; two pore potassium channel KT4.1; TWIK-related arachidonic acid-stimulated potassium channel protein
    • Species :
    • Human
    • Mouse
    • Source :
    • HEK293
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse Kcnk4-211M Recombinant Mouse Kcnk4 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human KCNK4-30H Recombinant Human KCNK4 protein, Myc/DDK-tagged HEK293 Myc/DDK
    Human KCNK4-323HCL Recombinant Human KCNK4 Lysate HEK293 Myc/DDK
    Mouse Kcnk4-1262M Recombinant Mouse Kcnk4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human KCNK4-5034HCL Recombinant Human KCNK4 293 Cell Lysate HEK293 N/A
    Mouse KCNK4-8533M Recombinant Mouse KCNK4 Protein Mammalian Cell His

    kcnk4 involved in several pathways and played different roles in them. We selected most pathways kcnk4 participated on our site, such as Neuronal System, Potassium Channels, TWIK related potassium channel (TREK), which may be useful for your reference. Also, other proteins which involved in the same pathway with kcnk4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuronal System KCNQ2; CHRNA5; SLC1A3B; KCNMB2; PPFIA4; SLC1A2A; KCNG4A; SLC6A12; ABCC9; KCNS2
    Potassium Channels KCNC2; KCNC1B; KCNMB2; KCND2; KCNK1; KCNC1A; ABCC9; KCNC4; KCNN1A; KCNC1
    TWIK related potassium channel (TREK) KCNK2B; KCNK10B; KCNK2; KCNK4
    Tandem pore domain potassium channels KCNK1; KCNK13A; KCNK3A; KCNK10B; KCNK2; KCNK1B; DDX1; KCNK16; KCNK13B; KCNK7

    kcnk4 has several biochemical functions, for example, mechanically-gated potassium channel activity, potassium channel activity, potassium ion leak channel activity. Some of the functions are cooperated with other proteins, some of the functions could acted by kcnk4 itself. We selected most functions kcnk4 had, and list some proteins which have the same functions with kcnk4. You can find most of the proteins on our site.

    Function Related Protein
    mechanically-gated potassium channel activity KCNK4
    potassium channel activity KCNK3A; KCNS3B; KCNC3A; KCNK4; KCNV2; KCNK1B; KCNC3B; TRPM5; KCNK15; KCNQ4
    potassium ion leak channel activity KCNK5B; KCNK4; KCNK18; KCNK1A; KCNK2; TMEM175; KCNK1; KCNK13B; KCNK9; DDX1
    temperature-gated cation channel activity KCNK4; TRPA1
    voltage-gated ion channel activity CLIC5B; CACNG2B; KCNJ1A.2; KCNC1B; CACNG7A; SCN12AA; KCNS3A; KCNK4; SCN4AB; KCNS3B

    kcnk4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with kcnk4 here. Most of them are supplied by our site. Hope this information will be useful for your research of kcnk4.

    RPL14; DIDO1

    Wu, J; Wu, X; et al. Overexpression of potassium channel ether a go-go1 in human osteosarcoma. NEOPLASMA 59:207-215(2012).
    Wang, L; Fyffe, REW; et al. Identification of a kv3.4 channel in corneal epithelial cells. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 45:1796-1803(2004).

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