KIT

  • Official Full Name

    v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

  • Overview

    This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms

    KIT; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog; PBT; SCFR; C-Kit; CD117; mast/stem cell growth factor receptor Kit; p145 c-kit; proto-oncogene c-Kit; piebald trait protein; soluble KIT variant 1; tyrosine-protein kinase Kit; proto-oncogene tyrosine-protein kinase Kit; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chromatography Reagents
  • Chicken
  • Dog
  • Human
  • Human
  • Mouse
  • Rat
  • Rhesus
  • Rhesus Macaque
  • Rhesus monkey
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Human Cells
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Sf21
  • Sf9 Insect Cell
  • C
  • hFc
  • His
  • DDK
  • DDK|His
  • DYKDDDDK
  • Fc
  • Fc|His
  • His(C
  • ter)
  • Flag
  • GST
  • hIgG1
  • hIgG4
  • His (Fc)
  • Avi
  • His|GST
  • His|T7
  • human|IgG1|Fc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KIT-113H Active Recombinant Human KIT(V559D V654A), GST-tagged Sf9 Insect Cell GST
Human KIT-86H Active Recombinant Human c-KIT Mutant (D820E), GST-tagged Sf9 Insect Cell GST
Human KIT-90H Active Recombinant Human c-KIT Mutant (V559D V654A), GST-tagged Sf9 Insect Cell GST
Human KIT-87H Active Recombinant Human c-KIT Mutant (N822K), GST-tagged Sf9 Insect Cell GST
Human KIT-88H Active Recombinant Human KIT Mutant (Y823D), GST-tagged Sf9 Insect Cell GST
Human KIT-85H Active Recombinant Human c-KIT Mutant (T670E), GST-tagged Sf9 Insect Cell GST
Human KIT-149H Active Recombinant Human KIT HEK293 N/A
Human KIT-89H Active Recombinant Human c-KIT Mutant (V559D T670I), GST-tagged Sf9 Insect Cell GST
Human KIT-12H Active Recombinant Human KIT, Fc Chimera HEK293 Fc
Human KIT-112H Active Recombinant Human KIT, GST-tagged Sf9 Insect Cell GST
Human KIT-818H Active Recombinant Human KIT, GST-tagged Sf9 Insect Cell GST 544-end
Human KIT-61H Active Recombinant Human KIT, GST-tagged Sf9 Insect Cell GST
Human KIT-32H Active Recombinant Human KIT(D816H)(544-end) Mutation Protein, N-GST-tagged Sf21 GST 544-end
Human KIT-36H Active Recombinant Human KIT(544-end) Protein, N-GST-tagged Sf21 GST 544-end
Human KIT-33H Active Recombinant Human KIT(D816V)(544-end) Mutation Protein, N-GST-tagged Sf21 GST 544-end
Human KIT-34H Active Recombinant Human KIT(V560G)(544-end) Mutation Protein, N-GST-tagged Sf21 GST 544-end
Human KIT-35H Active Recombinant Human KIT(V654A)(544-end) Mutation Protein, N-GST-tagged Sf21 GST 544-end
Human KIT-256H Recombinant Human KIT, GST-tagged, Active Sf9 Insect Cell GST
Human KIT-324H Recombinant Human KIT protein(Met1-Thr516), hFc-tagged HEK293 C-hFc Met1-Thr516
Human KIT-308H Recombinant Human KIT Mammalian Cell His
Human KIT-4857H Recombinant Human KIT v-kit Hardy-Zuckerman 4 Feline Sarcoma Viral Oncogene Homolog, GST-tagged Sf9 Insect Cell GST
Human KIT-002H Active Recombinant Human KIT, HIgG1 Fc-tagged, mutant CHO Fc
Human KIT-003H Active Recombinant Human KIT, HIgG1 Fc-tagged CHO Fc
Human KIT-30H Recombinant Human KIT (D816V) protein, GST-tagged E.coli GST
Human KIT-3947H Recombinant Human KIT protein, His-tagged HEK293 His Gln26-Thr516
Human KIT-001H Active Recombinant Human KIT, MIgG2a Fc-tagged CHO Fc
Human KIT-59H Recombinant Human KIT protein, Flag-tagged, Biotinylated Insect Cell Flag
Human KIT-794H Recombinant Human KIT protein, His & T7-tagged E.coli His/T7 Thr321~Pro520 (Accession # P10721)
Human KIT-396H Recombinant Human KIT protein, His-tagged E.coli His Val50-Gln190
Human KIT-389H Active Recombinant Human KIT Protein, His-tagged Insect cell His
Human KIT-540H Recombinant Human KIT, His-tagged Sf9 Insect Cell His
Human KIT-31H Recombinant Partial Human KIT (D816V) protein, GST-tagged E.coli GST
Human KIT-27174TH Recombinant Human KIT, His-tagged His
Human KIT-160H Recombinant Human KIT protein, DDK/His-tagged HEK293 DDK/His Gln26-Pro524
Human KIT-443H Recombinant Human KIT protein, Fc-tagged HEK293 human/IgG1/Fc Gln26-Thr516
Human KIT-161H Recombinant Human KIT protein, DDK-tagged Insect Cell DDK 546-976aa
Human KIT-162H Recombinant Human KIT protein, DDK/His-tagged HEK293 DDK/His Gln26-Pro520
Human KIT-001HCL Recombinant Human KIT cell lysate Human Cell N/A
Human KIT-463HCL Recombinant Human KIT cell lysate Insect Cell N/A
Human KIT-396HF Recombinant Human KIT Protein, His-tagged, FITC conjugated E.coli His 156
Human KIT-2048H Recombinant Human KIT Protein, Fc/His-tagged HEK293 Fc/His Gln26-Thr520
Human KIT-537H Recombinant Human KIT Protein (Thr540-Val972), His-GST-tagged Insect Cell His/GST Thr540-Val972
Human KIT-218H Recombinant Human KIT Protein, His-tagged Insect Cell His 26-524aa
Human KIT-3219H Recombinant Human KIT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human KIT-2761H Recombinant Human KIT protein, His-tagged E.coli His
Human KIT-152H Recombinant Human KIT Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human KIT-396HAF555 Recombinant Human KIT Protein, His-tagged, Alexa Fluor 555 conjugated E.coli His 156
Human KIT-1253H Recombinant Human KIT protein, His-tagged HEK293 His Gln26~Pro524
Human KIT-3947HAF488 Recombinant Human KIT Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His Gln26-Thr516
Human KIT-151H Recombinant Human KIT Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human KIT-443HAF555 Recombinant Human KIT Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Gln26-Thr516
Human KIT-1654H Recombinant Human KIT Protein, His-GST-tagged Insect Cell His/GST
Human KIT-3947HAF647 Recombinant Human KIT Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His Gln26-Thr516
Human KIT-443HAF488 Recombinant Human KIT Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Gln26-Thr516
Human KIT-396HAF647 Recombinant Human KIT Protein, His-tagged, Alexa Fluor 647 conjugated E.coli His 156
Human KIT-396HAF488 Recombinant Human KIT Protein, His-tagged, Alexa Fluor 488 conjugated E.coli His 156
Human KIT-3947HF Recombinant Human KIT Protein, His-tagged, FITC conjugated HEK293 His Gln26-Thr516
Human KIT-122H Recombinant Human KIT Protein, Fc-tagged HEK293 Fc 976
Human KIT-443HAF647 Recombinant Human KIT Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Gln26-Thr516
Human KIT-3947HAF555 Recombinant Human KIT Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His Gln26-Thr516
Human KIT-2365H Recombinant Human KIT Protein, His-tagged E.coli N-His Gln26-Pro524
Human KIT-2645H Active Recombinant Human KIT protein, hFc&His-tagged HEK293 hFc&His Gln26-Thr520
Human KIT-443HF Recombinant Human KIT Protein, hFc-tagged, FITC conjugated HEK293 hFc Gln26-Thr516
Human KIT-4347H Recombinant Human KIT Protein (Met1-IIe516), C-His tagged Mammalian cells C-His Met1-IIe516
Human KIT-223H Recombinant Human KIT Protein (ECD), Fc-His-tagged(C-ter) HEK293 Fc-His(C-ter) Gln26-Thr520
Human KIT-3219H-B Recombinant Human KIT Protein Pre-coupled Magnetic Beads HEK293
Human KIT-086H Recombinant Human KIT Protein, C-His-tagged E.coli C-His
Human KIT-5029H Recombinant Human KIT protein, hFc-tagged HEK293 hFc 26-516aa
Human KIT-121H Recombinant Human KIT Protein, His-tagged HEK293 His 976
Human KIT-0251H Active Recombinant Human KIT protein, His&Avi-tagged, Biotinylated HEK293 His&Avi Met1-Thr516
Human KIT-513H Active Recombinant Human KIT protein, hFc-tagged HEK293 hFc Met1-Pro524
Human KIT-1261H Recombinant Human KIT Protein (Thr321-Thr520), N-His tagged E.coli N-His Thr321-Thr520
Human KIT-514H Active Recombinant Human KIT protein, His-tagged HEK293 His Met1-Pro524
Human KIT-4348H Recombinant Human KIT Protein (Met1-Pro524), C-His tagged Mammalian cells C-His Met1-Pro524
Mouse KIT-1138M Recombinant Mouse KIT protein(Met1-Thr523), His-tagged HEK293 C-His Met1-Thr523
Mouse Kit-795M Recombinant Mouse Kit protein, His-tagged E.coli His Tyr343~Pro527 (Accession # P05532)
Mouse Kit-4037M Active Recombinant Mouse Kit protein(Met1-Thr523), hFc-tagged HEK293 C-hFc Met1-Thr523
Mouse Kit-4038M Recombinant Mouse Kit, His tagged Human Cell His
Mouse KIT-2114MCL Recombinant Mouse KIT cell lysate Human Cell N/A
Mouse Kit-4037MAF488 Recombinant Mouse Kit Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 740
Mouse KIT-563M KIT protein-coupled magnetic MicroBeads
Mouse Kit-4037MAF555 Recombinant Mouse Kit Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 740
Mouse Kit-4038MAF488 Recombinant Mouse Kit Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 510
Mouse Kit-4038MAF555 Recombinant Mouse Kit Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 510
Mouse Kit-4037MF Recombinant Mouse Kit Protein, Fc-tagged, FITC conjugated HEK293 Fc 740
Mouse Kit-4038MF Recombinant Mouse Kit Protein, His-tagged, FITC conjugated HEK293 His 510
Mouse Kit-4037MAF647 Recombinant Mouse Kit Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 740
Mouse Kit-4038MAF647 Recombinant Mouse Kit Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 510
Rat Kit-8773R Recombinant Rat Kit protein, His-tagged HEK293 His Met1-Thr522
Rat Kit-7486R Recombinant Rat Kit protein(Met1-Thr522), hFc-tagged HEK293 C-hFc Met1-Thr522
Rat KIT-1324RCL Recombinant Rat KIT cell lysate Human Cell N/A
Rat Kit-7486RF Recombinant Rat Kit Protein, Fc-tagged, FITC conjugated HEK293 Fc 738
Rat Kit-7486RAF555 Recombinant Rat Kit Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Fc 738
Rat Kit-8773RAF555 Recombinant Rat Kit Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 His 509
Rat Kit-7486RAF488 Recombinant Rat Kit Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Fc 738
Rat Kit-7486RAF647 Recombinant Rat Kit Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Fc 738
Rat Kit-8773RAF647 Recombinant Rat Kit Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 His 509
Rat Kit-8773RAF488 Recombinant Rat Kit Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 His 509
Rat Kit-8773RF Recombinant Rat Kit Protein, His-tagged, FITC conjugated HEK293 His 509
Rat Kit-2363R Recombinant Rat Kit Protein, His-tagged E.coli N-His Leu591-Ser938
Rhesus monkey KIT-1549R Recombinant Rhesus Monkey KIT Protein, hIgG4-tagged HEK293 hIgG4
Rhesus monkey KIT-1547R Recombinant Rhesus Monkey KIT Protein HEK293 N/A
Rhesus monkey KIT-1548R Recombinant Rhesus Monkey KIT Protein, hIgG1-tagged HEK293 hIgG1
Dog KIT-2364D Recombinant Dog KIT Protein, His-tagged E.coli N-His Gln28-Pro527
Rhesus KIT-2409R Active Recombinant Rhesus KIT protein(Met1-Thr520), His-tagged HEK293 C-His Met1-Thr520
Rhesus KIT-1550R Recombinant Rhesus KIT protein, hFc-tagged HEK293 hFc Met1-Thr520
Rhesus Macaque KIT-2230R Recombinant Rhesus Macaque KIT Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque KIT-2230R-B Recombinant Rhesus Macaque KIT Protein Pre-coupled Magnetic Beads HEK293
Chicken KIT-5932C Recombinant Chicken KIT Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

KIT involved in several pathways and played different roles in them. We selected most pathways KIT participated on our site, such as Ras signaling pathway, Rap signaling pathway, Cytokine-cytokine receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with KIT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ras signaling pathwayFGF14;RALB;TEK;FASLG;RASGRP3;GNGT1;HTR7;PLA2G12A;FLT4
Rap signaling pathwayPARD3;INS1;PRKCI;CALM1;GNAQ;FGF16;PRKCA;ANGPT1;PARD6B
Cytokine-cytokine receptor interactionTNF;IL17A;IL1R1;VEGFAA;IL23R;ACVR1L;BMPR2B;CXCL10;CCL4
Phospholipase D signaling pathwayCXCR2;INS1;GRM3;LPAR6;SHC2;RAF1;AVPR2;GAB2;MAPK3
EndocytosisRAB31;WAS;SNX2;ARF3;ITCH;EEA1;HSPA8;CSF1R;PML
PIK-Akt signaling pathwayYWHAH;IFNA12;ITGA6;Kitl;PDGFRB;ITGA3;INS2;TNXB;TEK
Hematopoietic cell lineageKITLG;CD5;IL11RA2;THPO;Flt3l;CD1E;GM-CSF;Cd24a;MME
MelanogenesisPRKCG;FZD1;FZD6;GNAQ;WNT2B;POMCA;GNAI1;CREB3L3A;PLCB4
Pathways in cancerPRKACB;PRKCA;PPARD;PIK3CD;IKBKB;PLCB1;HSP90AB1;CBLC;FZD10
Acute myeloid leukemiaBAD;NRAS;HRAS;CCNA1;PIK3CB;MAP2K2;TCF7;MAPK1;GRB2
Central carbon metabolism in cancerAKT2;SLC1A5;SIRT6;PGAM1;MAPK3;FLT3;SIRT3;PDHA2;PIK3CG

KIT has several biochemical functions, for example, ATP binding, cytokine binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KIT itself. We selected most functions KIT had, and list some proteins which have the same functions with KIT. You can find most of the proteins on our site.

Function Related Protein
ATP bindingFLT1;HKDC1;GLUL;ERBB4;CENPE;MYH1E;STK10;MYH1B;ACSBG1
cytokine bindingNRP1;CNTFR;CSF1R;CD74;CHRD;GBP1;PARK7;LIFR;TNFRSF11A
metal ion bindingPDCD2;C6AST3;ZNF143;PPM1LB;TRIM50;FGD4A;GNAL;ZNF688;PTS
protease bindingCstb;RNF139;MBP;SELL;DVL3;CD28;ALPI;FLOT1;ADAM8A
protein bindingHRAS;NPRL2;HDAC1;NDC80;FZD6;TOP1;GPKOW;MC4R;CARD9
protein homodimerization activityTYR;STUB1;EPHX2;CAMK2A;CDA;FLRT3;Il6ra;XPNPEP1;STK25
protein tyrosine kinase activityPTK2AA;FYN;FGFR1OP;MAP3K9;WEE2;CLK4;KDR;EPHA4A;CLK2
receptor signaling protein tyrosine kinase activityEGFR;ERBB2;EGFRA;ERBB4;INSR;LYN;TYRO3;ERBB3B;SYK
stem cell factor receptor activity
transmembrane receptor protein tyrosine kinase activityFLT1;MUSK;EPHA2A;TRIM27;ERBB3A;EPHB4B;ALK;EPHA4A;EGFRA

KIT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KIT here. Most of them are supplied by our site. Hope this information will be useful for your research of KIT.

PIK3R1; GRB2

  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does KIT gene expression vary in different tissues, and what factors contribute to tissue-specific regulation? 02/13/2022

KIT expression varies across tissues due to tissue-specific transcription factors, epigenetic modifications, and microenvironmental cues influencing its regulation.

How is the expression of the KIT gene regulated at the transcriptional level? 01/14/2022

Transcription factors like PU.1 and GATA-2, along with epigenetic modifications, regulate KIT gene expression.

Contribution of KIT gene to germ cell maintenance in the testes and ovaries? 01/17/2020

KIT is crucial for germ cell survival and proliferation; mutations may lead to infertility.

What is the role of KIT gene in stem cell biology and regenerative medicine? 12/25/2019

KIT maintains and influences stem cell behavior, holding potential in regenerative medicine.

Role of KIT gene in hematopoiesis and implications in hematological disorders? 11/03/2018

KIT is vital in hematopoietic stem cell development; mutations link to leukemia and mastocytosis.

Customer Reviews (3)

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Reviews
11/28/2020

    The quality control measures are evident in the performance of this product.

    04/02/2019

      Exceptional service!

      07/19/2018

        Rapid delivery! Ordered and received the product within a short timeframe, allowing us to proceed with our experiments without delays.

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