KLF4
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Official Full Name
Kruppel-like factor 4 (gut)
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Overview
Krueppel-like factor 4 is a protein that in humans is encoded by the KLF4 gene.. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSC -
Synonyms
KLF4; Kruppel-like factor 4 (gut); Krueppel-like factor 4; EZF; GKLF; gut-enriched krueppel-like factor; epithelial zinc finger protein EZF; endothelial Kruppel-like zinc finger protein;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- 13
- TAT
- Flag
- His
- His (Fc)
- Avi
- His|CaM
- His|T7
- MYC
- DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
KLF4 involved in several pathways and played different roles in them. We selected most pathways KLF4 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | WNT6;WNT10B;IGF1R;LHX5;MAPK1;GRB2;ACVR1;BMPR1A;HNF1A |
KLF4 has several biochemical functions, for example, RNA polymerase II transcription factor binding, beta-catenin binding, core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF4 itself. We selected most functions KLF4 had, and list some proteins which have the same functions with KLF4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II transcription factor binding | TRP53;SPI1;GATA1A;GATA4;PITX2;TBX20;ATF4;MIXL1;TP53 |
| beta-catenin binding | TCF7L1A;GLI3;EP300;CD2AP;CDH24;SMAD7;TCF7L1B;CARM1;PTPRJ |
| core promoter binding | MYBBP1A;GADD45A;PSPC1;E2F8;KLF4;INSM1A;NONO;IRF9;KDM3A |
| core promoter proximal region sequence-specific DNA binding | CXXC1;KLF1;DMRT3;DMRTC1B;GATA3;MIXL1;SP3A;SMAD4;DMRT3A |
| histone deacetylase binding | SRF;PKN2;MYOCD;FOXP3;TCF21;CEBPA;HDAC10;GCM1;MECP2 |
| phosphatidylinositol 3-kinase regulator activity | PIK3R3B;PIK3R1;KLF4;AGAP2;PIK3R3A |
| protein binding | SERPINA1;POU5F1;C1QTNF9B-AS1;BAG4;ZNF317;KIF1C;SSB;RPH3A;KARS |
| transcription cofactor binding | TRP53;KLF4;CHD6;FOXO3 |
| transcription factor activity, sequence-specific DNA binding | NFIL3-6;ETV6;SIM1;ZNF165;NR6A1B;SMAD3B;TBX4;HEY2;MAFG |
| transcription factor activity, sequence-specific DNA binding transcription factor recruiting | |
| transcription regulatory region DNA binding | PAX8;NR1D1;KDM1A;NR1H3;SNCA;FOXA2;MEF2C;SALL1A;TAF7 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | CREB1;MEIS1;LEF1;ISL1;EBF4;PLSCR1;EHF;HOXA5;CEBPE |
| transcriptional activator activity, RNA polymerase II transcription factor binding | NKX2;MED12;KLF14;MIXL1;LMO2;GBX2;NOTCH1;CREB1;SOX10 |
| zinc ion binding | ZNF185;FTR50;GLO1;RBM14B;PEX2;RXRA;MSRB2;MMP26;KDM5D |
KLF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF4.
cd14_distal_promoter_probe; CTBP1; Dlg4
Research Area
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