KLF4

  • Official Full Name

    Kruppel-like factor 4 (gut)

  • Overview

    Krueppel-like factor 4 is a protein that in humans is encoded by the KLF4 gene.. In embryonic stem cells (ESCs), KLF4 has been demonstrated to be a good indicator of stem-like capacity. It is suggested that the same is true in mesenchymal stem cells (MSC
  • Synonyms

    KLF4; Kruppel-like factor 4 (gut); Krueppel-like factor 4; EZF; GKLF; gut-enriched krueppel-like factor; epithelial zinc finger protein EZF; endothelial Kruppel-like zinc finger protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • 13
  • TAT
  • Flag
  • His
  • His (Fc)
  • Avi
  • His|CaM
  • His|T7
  • MYC
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KLF4-72H Active Recombinant Human KLF4 protein E.coli N/A
Human KLF4-29898TH Recombinant Human KLF4, His-tagged E.coli His 385 amino acids
Human KLF4-29901TH Recombinant Human KLF4 N/A
Human KLF4-8466H Recombinant Human KLF4, His-tagged E.coli His
Human KLF4-3567H Recombinant Human KLF4, His CaM-tagged E.coli His/CaM
Human KLF4-145H Recombinant Human KLF4 Protein, 13-residue TAT-tagged HEK293 13-TAT
Human KLF4-4927HCL Recombinant Human KLF4 293 Cell Lysate HEK293 N/A
Human KLF4-1250H-B Recombinant Human KLF4 Protein Pre-coupled Magnetic Beads HEK293
Human KLF4-1250H Recombinant Human KLF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human KLF4-3260H Recombinant Human KLF4 Protein (Leu352-Phe513), N-His tagged E.coli N-His Leu352-Phe513
Human KLF4-271HFL Active Recombinant Full Length Human KLF4 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Klf4-5856M Recombinant Mouse Klf4 protein, His & T7-tagged E.coli His/T7 Ser240~His478 (Accession # Q60793)
Mouse Klf4-1276M Recombinant Mouse Klf4 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque KLF4-2415R Recombinant Rhesus monkey KLF4 Protein, His-tagged Mammalian Cell His
Rhesus Macaque KLF4-2236R Recombinant Rhesus Macaque KLF4 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque KLF4-2236R-B Recombinant Rhesus Macaque KLF4 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish KLF4-6294Z Recombinant Zebrafish KLF4 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

KLF4 involved in several pathways and played different roles in them. We selected most pathways KLF4 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLF4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling pathways regulating pluripotency of stem cellsWNT6;WNT10B;IGF1R;LHX5;MAPK1;GRB2;ACVR1;BMPR1A;HNF1A

KLF4 has several biochemical functions, for example, RNA polymerase II transcription factor binding, beta-catenin binding, core promoter binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KLF4 itself. We selected most functions KLF4 had, and list some proteins which have the same functions with KLF4. You can find most of the proteins on our site.

Function Related Protein
RNA polymerase II transcription factor bindingTRP53;SPI1;GATA1A;GATA4;PITX2;TBX20;ATF4;MIXL1;TP53
beta-catenin bindingTCF7L1A;GLI3;EP300;CD2AP;CDH24;SMAD7;TCF7L1B;CARM1;PTPRJ
core promoter bindingMYBBP1A;GADD45A;PSPC1;E2F8;KLF4;INSM1A;NONO;IRF9;KDM3A
core promoter proximal region sequence-specific DNA bindingCXXC1;KLF1;DMRT3;DMRTC1B;GATA3;MIXL1;SP3A;SMAD4;DMRT3A
histone deacetylase bindingSRF;PKN2;MYOCD;FOXP3;TCF21;CEBPA;HDAC10;GCM1;MECP2
phosphatidylinositol 3-kinase regulator activityPIK3R3B;PIK3R1;KLF4;AGAP2;PIK3R3A
protein bindingSERPINA1;POU5F1;C1QTNF9B-AS1;BAG4;ZNF317;KIF1C;SSB;RPH3A;KARS
transcription cofactor bindingTRP53;KLF4;CHD6;FOXO3
transcription factor activity, sequence-specific DNA bindingNFIL3-6;ETV6;SIM1;ZNF165;NR6A1B;SMAD3B;TBX4;HEY2;MAFG
transcription factor activity, sequence-specific DNA binding transcription factor recruiting
transcription regulatory region DNA bindingPAX8;NR1D1;KDM1A;NR1H3;SNCA;FOXA2;MEF2C;SALL1A;TAF7
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingCREB1;MEIS1;LEF1;ISL1;EBF4;PLSCR1;EHF;HOXA5;CEBPE
transcriptional activator activity, RNA polymerase II transcription factor bindingNKX2;MED12;KLF14;MIXL1;LMO2;GBX2;NOTCH1;CREB1;SOX10
zinc ion bindingZNF185;FTR50;GLO1;RBM14B;PEX2;RXRA;MSRB2;MMP26;KDM5D

KLF4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLF4 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLF4.

cd14_distal_promoter_probe; CTBP1; Dlg4

Research Area

Related articles

Makanga, JO; Kobayashi, M; et al. Generation of Rat Induced Pluripotent Stem Cells Using a Plasmid Vector and Possible Application of a Keratan Sulfate Glycan Recognizing Antibody in Discriminating Teratoma Formation Phenotypes. BIOLOGICAL & PHARMACEUTICAL BULLETIN 38:127-133(2015).
Shimamoto, R; Amano, N; et al. Generation and Characterization of Induced Pluripotent Stem Cells from Aid-Deficient Mice. PLOS ONE 9:-(2014).
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