KLRC3

  • Official Full Name

    killer cell lectin-like receptor subfamily C, member 3

  • Overview

    Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. KLRC3 is a member of the NKG2 group which are expressed primarily in natural killer (NK) cells and encodes a family of transmembrane proteins characterized by a type II membrane orientation (extracellular C terminus) and the presence of a C-type lectin domain. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed on NK cells. Alternative splicing results in multiple transcript variants encoding different isoforms.
  • Synonyms

    KLRC3; killer cell lectin-like receptor subfamily C, member 3; NKG2-E type II integral membrane protein; NKG2 E; Killer cell lectin like receptor subfamily C member 3; KLRC 3; NK cell receptor E; NKG2 E activating NK receptor; NKG2 E type II integral membrane protein; NKG2-E-activating NK receptor; NKG2E activating NK receptor; NKG2E; NKG2E type II integral membrane protein; NKG2E_HUMAN; OTTHUMP00000235359; OTTHUMP00000235362; NKG2-E;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rhesus Macaque
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human KLRC3-7170H Recombinant Human Killer Cell Lectin-Like Receptor Subfamily C, Member 3, His-tagged E.coli His 94-240aa
Human KLRC3-29905TH Recombinant Human KLRC3 Wheat Germ N/A 109 amino acids
Human KLRC3-4913H Recombinant Human KLRC3 Protein, GST-tagged Wheat Germ GST
Rhesus Macaque KLRC3-2437R Recombinant Rhesus monkey KLRC3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque KLRC3-2258R-B Recombinant Rhesus Macaque KLRC3 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque KLRC3-2258R Recombinant Rhesus Macaque KLRC3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

KLRC3 involved in several pathways and played different roles in them. We selected most pathways KLRC3 participated on our site, such as Antigen processing and presentation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with KLRC3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Antigen processing and presentationHLA-DRB4;KIR3DL1;HSPA1L;KLRC4;CD8B1;RFXANK;HLA-B;CD8B;HSPA2
Natural killer cell mediated cytotoxicityKLRC4-KLRK1;RAC2;SHC2;ULBP1;IFNA12;MICA;PRKCB;PPP3R2;ICAM1

KLRC3 has several biochemical functions, for example, carbohydrate binding, transmembrane signaling receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by KLRC3 itself. We selected most functions KLRC3 had, and list some proteins which have the same functions with KLRC3. You can find most of the proteins on our site.

Function Related Protein
carbohydrate bindingVCAN;SIGLEC8;SORD;LGALSLB;CLEC4A;OS9;PVRL1;CALR;ASGR2
transmembrane signaling receptor activityIL27RA;CLDN4;KLRD1;FZD9B;CD27;SLAMF1;LGR5;MARCO;LYVE1

KLRC3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KLRC3 here. Most of them are supplied by our site. Hope this information will be useful for your research of KLRC3.

clpB

Research Area

Related articles

Lee, YH; Bae, SC; et al. Meta-analysis of gene expression profiles to predict response to biologic agents in rheumatoid arthritis. CLINICAL RHEUMATOLOGY 33:775-782(2014).
Nakata, S; Imagawa, A; et al. Low gene expression levels of activating receptors of natural killer cells (NKG2E and CD94) in patients with fulminant type 1 diabetes. IMMUNOLOGY LETTERS 156:149-155(2013).
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