KRT18
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Official Full Name
keratin 18
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Background
KRT18 encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] -
Synonyms
KRT18; keratin 18; K18; CYK18; keratin, type I cytoskeletal 18; CK-18; keratin-18; cytokeratin 18; cytokeratin-18; cell proliferation-inducing protein 46; cell proliferation-inducing gene 46 protein;
- Involved Pathway
- Protein Function
- Interacting Protein
KRT18 involved in several pathways and played different roles in them. We selected most pathways KRT18 participated on our site, such as Pathogenic Escherichia coli infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with KRT18 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Pathogenic Escherichia coli infection | TUBA8;TUBB2B;TUBB7P;RHOA;TUBA1A;TUBA4A;CTTN;TUBA3D;ROCK1 |
KRT18 has several biochemical functions, for example, poly(A) RNA binding, protein binding, scaffold protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by KRT18 itself. We selected most functions KRT18 had, and list some proteins which have the same functions with KRT18. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | NOLC1;RAN;PSMC1;MYH9;GPATCH8;STXBP1;PRDX1;DDX18;DDX6 |
| protein binding | GPR19;SSB;MACROD1;VPS52;TIA1;MYO5B;RMI1;SPTAN1;INCENP |
| scaffold protein binding | SCN5A;KRT8;CAV2;KRT5;GRID2;CASP8;DLG4;NLGN3;NCK2 |
| structural molecule activity | COPG;KRT27;PNN;TUBG2;CLDN7A;CLDN20;CLDN15;CLDN10;CLDNB |
KRT18 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with KRT18 here. Most of them are supplied by our site. Hope this information will be useful for your research of KRT18.
KRT8; YWHAZ; DNAJB6; TRADD
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