LCK
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Official Full Name
lymphocyte-specific protein tyrosine kinase
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Overview
Lck is a 56 kD tyrosine protein kinase and a member of the src subfamily that contains both an SH2 and SH3 domain. Alternatively spliced isoforms of Lck have been reported. Lck is a cytoplasmic protein bound to CD4 and CD8 in T lymphocytes that participat -
Synonyms
LCK; lymphocyte-specific protein tyrosine kinase; tyrosine-protein kinase Lck; leukocyte C-terminal Src kinase; p56(LSTRA) protein-tyrosine kinase; t cell-specific protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; lymphocyte cell-specif;
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- Involved Pathway
- Protein Function
- Interacting Protein
- LCK Related Articles
LCK involved in several pathways and played different roles in them. We selected most pathways LCK participated on our site, such as NF-kappa B signaling pathway, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with LCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| NF-kappa B signaling pathway | TNFAIP3;TRAF2;TRIM25;Bcl2a1b;TNFSF11;BCL2A1A;TNFRSF1A;VCAM1;CFLAR |
| Osteoclast differentiation | GRB2;IFNAR1;IL1A;TYK2;NCF2;NOX3;LILRA3;STAT2;FCGR4 |
| Natural killer cell mediated cytotoxicity | PPP3R1;ULBP2;KRAS;IFNA14;ZAP70;VAV2;PIK3CB;CD244;IFNA1 |
| T cell receptor signaling pathway | FOS;MAPK11;MAPK1;CD8B;MAP3K14;PPP3CA;MAPK3;FYN;PAK3 |
| HTLV-I infection | NFATC2;PDGFA;LTBR;IL1R2;FZD2;MSX2;TGFB1;POLE;TBP |
| Primary i | RAG1;AIRE;TNFRSF13B;IL7R;BTK;IGLL1;CD40;ICOS;CD19 |
| nodeficiency | CD3E;DCLRE1C;CD40LG;IL7R;AICDA;IKBKG;CD8B;BTK;BLNK |
LCK has several biochemical functions, for example, ATP binding, ATPase binding, CD4 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LCK itself. We selected most functions LCK had, and list some proteins which have the same functions with LCK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ACACB;STK39;DYNC2H1;MAST4;GKUP;GALK2;OAS2;ATP13A;UPF1 |
| ATPase binding | PEX19;FXYD1;METTL21A;ABCA1;WFS1;TAF9;NKAIN1;TOR1AIP2;DERL1 |
| CD4 receptor binding | SPG21;PLSCR1;FYN;PLSCR4;LCK |
| CD8 receptor binding | FYN;LCK |
| SH2 domain binding | SRC;MS4A2;SKAP1;LAX1;LILRB1;SQSTM1;AFAP1L2;CRK;PAG1 |
| antigen binding | TGFB1;KIR2DL3;LILRB4;LILRA1;LILRA3;MHC1UKA;Ighg2a;IGLL1;SLAMF1 |
| glycoprotein binding | TFR2;FBXO2;TGFB1;LGALS1;ACE2;RASA1;FBXO17;BBC3;Serpina1c |
| identical protein binding | VIM;RPE;EPS15;FBLN1;CASP6;SERPINA1E;TTN;GSTM3;NOXO1 |
| non-membrane spanning protein tyrosine kinase activity | MATK;ZAP70;TNK1;FRK;PRKCD;ZNF143B;PTK2AB;JAK1;YRK |
| phosphatidylinositol 3-kinase binding | INSR;IGF1RB;CALM3;BECN1;PIK3R1;IGF1R;HCST;INSRA;IRS4 |
| protein C-terminus binding | PROP1;FOXN3;VGLL3;TBL1X;COIL;SLC9A3R2;AXIN1;CSK;XRCC5 |
| protein binding | CD70;UBTD1;MCM10;C12orf5;DNAJC11;MECP2;DCTN2;PDK1;DHX15 |
| protein complex binding | CPS1;CRHR1;MYSM1;GIT2;PPP2R2A;TULP3;BRK1;LAMB3;SKIL |
| protein kinase binding | CDK5RAP1;EMP2;IL12RB2;GRIN2A;CCNE1;KCNH1;TNNI3;TRP53;TPCN2 |
| protein phosphatase binding | ITPR1;PPME1;CTNNB1;PPP1R3G;TRAF3;RPA2;DLG3;ANAPC4;ANAPC7 |
| protein serine/threonine phosphatase activity | CDC14A;PPM1A;PPM1J;CTDNEP1A;TIMM50;PPP1CC;CDC14C;EPM2A;PPM1K |
| protein tyrosine kinase activity | PTK2;PTK7;NEK1;ERBB2;TESK1;ROS1;PTK2B;MAP2K3;KDRL |
LCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LCK here. Most of them are supplied by our site. Hope this information will be useful for your research of LCK.
PTPRC; KHDRBS1; tip_shv2c
- Q&As
- Reviews
Q&As (7)
Ask a questionLCK plays a vital role in the development and maturation of T cells in the thymus, especially during the processes of positive and negative selection, ensuring the generation of a functional and self-tolerant T-cell repertoire.
Yes, LCK activity can be modulated by several pharmacological agents, including kinase inhibitors like dasatinib, which have been explored for therapeutic purposes in various diseases.
LCK activation is regulated post-translationally through phosphorylation at specific tyrosine residues, with its activity being modulated by both activating and inhibitory phosphorylations.
LCK is a pivotal Src family kinase that plays a crucial role in initiating T-cell receptor (TCR) signaling by phosphorylating key tyrosines on the CD3 and ζ-chains of the TCR complex.
LCK interacts with other kinases such as ZAP-70 and Fyn in T-cell signaling pathways, orchestrating a cascade of phosphorylation events that lead to T-cell activation.
Dysregulation of LCK has been associated with various conditions, including autoimmune diseases, immunodeficiencies, and certain leukemias.
LCK contributes to TCR complex formation and activation by phosphorylating the immunoreceptor tyrosine-based activation motifs (ITAMs) on the TCR, facilitating the recruitment and activation of ZAP-70 kinase.
Customer Reviews (3)
Write a reviewGood stability, long shelf-life.
Consistent quality across batches.
Pure product, reliable results.
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