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Official Full Name lymphocyte-specific protein tyrosine kinase
Background Lck is a 56 kD tyrosine protein kinase and a member of the src subfamily that contains both an SH2 and SH3 domain. Alternatively spliced isoforms of Lck have been reported. Lck is a cytoplasmic protein bound to CD4 and CD8 in T lymphocytes that participat
Synonyms LCK; lymphocyte-specific protein tyrosine kinase; tyrosine-protein kinase Lck; leukocyte C-terminal Src kinase; p56(LSTRA) protein-tyrosine kinase; t cell-specific protein-tyrosine kinase; proto-oncogene tyrosine-protein kinase LCK; lymphocyte cell-specif
    • Species :
    • Human
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • S.frugiperda
    • Sf9 Insect Cell
    • Tag :
    • Flag
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LCK-1424H Recombinant Human LCK (Active), GST-tagged Sf9 Insect Cell GST
    Human LCK-16H Recombinant Human LCK, His-tagged E.coli His
    Human LCK-173H Recombinant Human LCK E.coli N/A
    Human LCK-174H Recombinant Human LCK, SH3 Domain, GST-tagged E.coli GST
    Human LCK-273H Recombinant Human LCK, MYC/DDK-tagged HEK293 Myc/DDK
    Human LCK-29218TH Recombinant Human LCK E.coli N/A
    Human LCK-29937TH Recombinant Human LCK N/A
    Human LCK-342H Recombinant Human LCK, GST-tagged, Active Sf9 Insect Cell GST
    Human LCK-573H Recombinant Human LCK, GST-tagged Sf9 Insect Cell GST
    Human LCK-60H Recombinant Human LCK protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human LCK-681HCL Recombinant Human LCK cell lysate Insect Cell N/A
    Human LCK-692H Recombinant Human LCK, His-tagged S.frugiperda His
    Human LCK-776H Recombinant Human LCK, GST tagged Insect Cell GST
    Rat LCK-3365R Recombinant Rat LCK Protein Mammalian Cell His
    Zebrafish LCK-220Z Recombinant Zebrafish LCK Mammalian Cell His
    Kit-0508 p56Lck Kinase (Human) Assay/Inhibitor Screening Assay Kit N/A

    lck involved in several pathways and played different roles in them. We selected most pathways lck participated on our site, such as NF-kappa B signaling pathway, Osteoclast differentiation, Natural killer cell mediated cytotoxicity, which may be useful for your reference. Also, other proteins which involved in the same pathway with lck were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    NF-kappa B signaling pathway PLAU; BCL2L1; TNFAIP3; TRAF6; TICAM2; CCL4L2; Ccl21a; TRAF2; TNFRSF1A; BCL2A1A
    Osteoclast differentiation LILRA4; FCGR2B; RELA; IL1R1; SIRP-BETA; PIK3R3; PIK3R1; MAPK8; IFNB1; TYROBP
    Natural killer cell mediated cytotoxicity CD247; IFNB1; LCP2; RAF1; VAV3; PTPN11; ARAF; PTK2B; PPP3CB; RAC1
    T cell receptor signaling pathway NFKBIE; CABIN1; MAP3K7; MAPK12; NRAS; CD8B; CBLC; CD40LG; PIK3CB; EVLB
    HTLV-I infection CD3G; ATF4; WNT5A; HLA-DRB4; ITGB2; ANAPC11; FOS; KAT2B; HLA-C; TRP53
    Primary i IKBKG; RAG1; IL2RG; DCLRE1C; CD40LG; IL7R; AICDA; CD40; ZAP70; IGLL1
    nodeficiency ZAP70; RFXANK; CD8B; DCLRE1C; ICOS; BLNK; TAP1; IL2RG; IKBKG; CD40

    lck has several biochemical functions, for example, ATP binding, ATPase binding, CD4 receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by lck itself. We selected most functions lck had, and list some proteins which have the same functions with lck. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding BCS1L; VARS2; DNAJA3A; GUK1; STK25A; STK30; PPIP5K1; UBE2K; NUBP1; NLK1
    ATPase binding TOR1AIP2; DNAJB1; ATP6V0A4; SDF2L1; FXYD1; NUFIP1; DRD1; FXYD7; ATP1B1; ESR1
    CD4 receptor binding FYN; LCK; PLSCR1; SPG21; PLSCR4
    CD8 receptor binding FYN; LCK
    SH2 domain binding INPPL1; PAG1; SHCBP1; IRS1; LAX1; JAK2; MS4A2; SKAP1; TRPV4; SYP
    antigen binding LILRA2; IGHM; TSPAN4; SLAMF1; FCN3; LILRA1; LILRB4; IL7R; LILRA3; IGJ
    glycoprotein binding BMPR1B; SHB; DNAJA2; FBXO6; CDH1; LCK; LGALS1; EDEM2; FBXO2; PLAT
    identical protein binding INS2; RUVBL2; PCM1; LDHA; RBM10; AKT1; HSD17B10; KCTD13; GCG; HJURP
    non-membrane spanning protein tyrosine kinase activity PTK2AA; PTK6B; PRKCD; FYNB; JAK2; TNK2; TXK; RIPK2; ABL2; Fert2
    phosphatidylinositol 3-kinase binding ATP1A1; IGF1R; FLT3; HCST; CALM3; CALM2; IGF1RA; INSRR; DAB1; IGF1RB
    protein C-terminus binding CDC20; FBLN1; AXIN1; LCK; C11orf60; CORO1A; VTA1; AP2A1; VPS36; ITGB3BP
    protein binding PHOSPHO2-KLHL23; RAB32; ANXA9; SMARCB1; LAIR1; ADAM23; APLF; SMARCE1; CTNNAL1; IKZF3
    protein complex binding CEBPA; NCKAP1; MAPK8IP2; SIX2; EPCAM; LRRC16A; CALY; KCTD5; VPS28; AP2A1
    protein kinase binding AKAP1; FBXW5; KAT2B; TP73; TTN; CDK5RAP2; YWHAZ; WAS; PDCD10; MEF2A
    protein phosphatase binding CDC27; JAK1; ANAPC4; AP3B1; GNB2L1; CDH5; ANAPC7; DLG3; ITPR1; PIK3R1
    protein serine/threonine phosphatase activity PPM1F; DUSP23; PPM1BB; PPM1AB; CDC14A; PDP2; PPP6C; PPA2; PPM1G; PPM1J
    protein tyrosine kinase activity SYK; EPHB2; MAP2K1; KIT; KITA; ALK; KIAA1804; NTRK2B; TNK2B; MAP2K4

    lck has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with lck here. Most of them are supplied by our site. Hope this information will be useful for your research of lck.

    PTPRC; KHDRBS1; tip_shv2c

    Guo, N; Zhang, K; et al. CD147 and CD98 complex-mediated homotypic aggregation attenuates the CypA-induced chemotactic effect on Jurkat T cells. MOLECULAR IMMUNOLOGY 63:253-263(2015).
    Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).

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