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LIFR

  • Official Full Name

    Leukemia Inhibitory Factor Receptor

  • Overview

    LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.
  • Synonyms

    LIFR; Interferon α Receptor β Chain; leukemia inhibitory factor receptor alpha; SWS; SJS2; STWS; CD118; LIF-R; FLJ98106; FLJ99923; leukemia inhibitory factor receptor; CD118 antigen; LIF receptor;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human Cell
  • Insect Cell
  • Insect cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Wheat Germ
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • human|IgG1|Fc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LIFR-687H Active Recombinant Human LIFR HEK293 N/A
Human LIFR-044H Active Recombinant Human LIFR Protein, Fc-tagged HEK293 Fc
Human LIFR-611H Active Recombinant Human LIFR protein(Met1-Ser833), His-tagged HEK293 C-His Met1-Ser833
Human LIFR-1663H Recombinant Human Leukemia Inhibitory Factor Receptor Alpha Sf21 Insect Cell N/A
Human LIFR-28855TH Recombinant Human LIFR Wheat Germ N/A 110 amino acids
Human LIFR-30H Recombinant Human LIFR protein, His-tagged Insect Cell His
Human LIFR-2818H Recombinant Human LIFR protein, His-tagged E.coli His Trp522~Phe691 (Accession # P42702)
Human LIFR-2817H Recombinant Human LIFR protein, His-tagged E.coli His Gln45~Leu184 (Accession # P42702)
Human LIFR-612H Recombinant Human LIFR protein, Fc-tagged HEK293 human/IgG1/Fc 789
Human LIFR-2819H Recombinant Human LIFR protein, His-tagged E.coli His Arg692~Ser833 (Accession # P42702)
Human LIFR-2778HCL Recombinant Human LIFR cell lysate Human Cell N/A
Human LIFR-0358H Active Recombinant Human LIFR protein, Fc-tagged HEK293 Fc Gln45-Ser833
Human LIFR-351H Recombinant Human LIFR Protein, Fc-tagged HEK293 Fc 1097
Human LIFR-1085H Recombinant Human LIFR protein(Met1-Ser833), His-tagged, Biotinylated HEK293 C-His Met1-Ser833
Human LIFR-094H Recombinant Human LIFR Protein, C-His-tagged E.coli C-His
Human LIFR-4445H Recombinant Human LIFR Protein (Met1-Ser833), C-His tagged Mammalian cells C-His Met1-Ser833
Mouse LIFR-868M Active Recombinant Mouse LIFR protein(Met1-Ser828), His-tagged HEK293 C-His Met1-Ser828
Mouse Lifr-3295M Active Recombinant Mouse Lifr, His-tagged Human Cell GST
Mouse Lifr-2820M Recombinant Mouse Lifr protein, His-tagged E.coli His Lys151~Gln290 (Accession # P42703)
Mouse Lifr-2821M Recombinant Mouse Lifr protein, His-tagged E.coli His Glu381~Ser485 (Accession # P42703)
Mouse Lifr-2822M Recombinant Mouse Lifr protein, His-tagged E.coli His Thr641~Thr790 (Accession # P42703)
Mouse LIFR-2285MCL Recombinant Mouse LIFR cell lysate Human Cell N/A
Mouse Lifr-021M Active Recombinant Mouse Lifr Protein, His-tagged Insect cells His
Rat LIFR-3408R Active Recombinant Rat LIFR protein, His-tagged HEK293 His Met1-Ser829
Rat Lifr-8774R Recombinant Rat Lifr, His tagged Human Cell N/A
Rat Lifr-2824R Recombinant Rat Lifr protein, His-tagged E.coli His Glu382~Ser486 (Accession # O70535)
Rat Lifr-2823R Recombinant Rat Lifr protein, His-tagged E.coli His Lys152~Glu291 (Accession # O70535)
Rat Lifr-2825R Recombinant Rat Lifr protein, His-tagged E.coli His Ser642~Thr791 (Accession # O70535)
Rat LIFR-1200RCL Recombinant Rat LIFR cell lysate Human Cell N/A
Rat LIFR-3064R Recombinant Rat LIFR Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat LIFR-3064R-B Recombinant Rat LIFR Protein Pre-coupled Magnetic Beads HEK293
Chicken LIFR-6144C Recombinant Chicken LIFR Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • LIFR Related Articles
  • LIFR Related Gene Family
  • LIFR Related Research Area

LIFR involved in several pathways and played different roles in them. We selected most pathways LIFR participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIFR were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIFNK;TNFSF14;Flt3l;INHBB;CCR7;TNFRSF21;CRLF2;IFNGR1;CTF1
Signaling pathways regulating pluripotency of stem cellsFZD9;MAPK13;ACVR1C;WNT1;ACVR1;LEFTY2;WNT2;WNT11;NEUROG1
Jak-STAT signaling pathwayIFNA12;MCL1A;AKT2;IL20RA;AOX2P;IFNA7;SOCS9;CSF3;GRB2

LIFR has several biochemical functions, for example, contributes_to ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, cytokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIFR itself. We selected most functions LIFR had, and list some proteins which have the same functions with LIFR. You can find most of the proteins on our site.

Function Related Protein
contributes_to ciliary neurotrophic factor receptor activityCNTFR;LIFR;Il6ra;IL6R
ciliary neurotrophic factor receptor bindingCLCF1;CNTF;LIFR;IL6ST;Ctf2
cytokine bindingCRLF1;CXCR4;TNFRSF11A;IL31RA;NOG;Fzd4;PARK7;CSF1R;KIT
growth factor bindingKDR;ACVR1C;IGFBP2A;LTBP2;NRP1;GHR;NRP2;RHBDF1;HTRA1B
leukemia inhibitory factor receptor activity
contributes_to leukemia inhibitory factor receptor activityLIFR;IL6ST
contributes_to oncostatin-M receptor activityIL6ST;OSMR;LIFR
protein heterodimerization activityTENM3;UGT1A9;UBXN6;ATF3;HIST1H2AL;H2-AB1;SMAD3;PRSS28;RAB3GAP2

LIFR has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIFR here. Most of them are supplied by our site. Hope this information will be useful for your research of LIFR.

OSM; LIF; CNTF; PRPF4; BAG3; Bmpr1a; GOLT1B

Sommer, J; Engelowski, E; et al. Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:651-660(2014).
Larrea, E; Echeverria, I; et al. Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection. JOURNAL OF HEPATOLOGY 60:482-489(2014).
IL
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