lifr

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lifr

Official Full Name Leukemia Inhibitory Factor Receptor
Background LIFR also known as CD118 (Cluster of Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor is a polyfunctional cytokine that affects the differentiation, survival, and proliferation of a wide variety of cells in the adult and the embryo. LIF action appears to be mediated through a high-affinity receptor complex composed of a low-affinity LIF binding chain (LIF receptor) and a high-affinity converter subunit, gp130. Both LIFR and gp130 are members of a family of cytokine receptors that includes components of the receptors for the majority of hematopoietic cytokines and for cytokines that affect other systems, including the ciliary neurotrophic factor, growth hormone and prolactin.
Synonyms LIFR; Interferon α Receptor β Chain; leukemia inhibitory factor receptor alpha; SWS; SJS2; STWS; CD118; LIF-R; FLJ98106; FLJ99923; leukemia inhibitory factor receptor; CD118 antigen; LIF receptor
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Insect cells
    • Mammalian Cell
    • Sf21 Insect Cell
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • human
    • IgG1
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human LIFR-044H Recombinant Human LIFR Protein, Fc-tagged HEK293 Fc
    Human LIFR-1663H Recombinant Human Leukemia Inhibitory Factor Receptor Alpha Sf21 Insect Cell N/A
    Human LIFR-2778HCL Recombinant Human LIFR cell lysate Human Cell N/A
    Human LIFR-2817H Recombinant Human LIFR protein, His-tagged E.coli His
    Human LIFR-2818H Recombinant Human LIFR protein, His-tagged E.coli His
    Human LIFR-2819H Recombinant Human LIFR protein, His-tagged E.coli His
    Human LIFR-28855TH Recombinant Human LIFR Wheat Germ N/A
    Human LIFR-30H Recombinant Human LIFR protein, His-tagged Insect Cell His
    Human LIFR-611H Recombinant Human LIFR, His tagged Human Cell His
    Human LIFR-612H Recombinant Human LIFR protein, Fc-tagged HEK293 human/IgG1/Fc
    Human LIFR-687H Recombinant Human LIFR HEK293 N/A
    Mouse Lifr-021M Recombinant Mouse Lifr Protein, His-tagged Insect cells His
    Mouse LIFR-2285MCL Recombinant Mouse LIFR cell lysate Human Cell N/A
    Mouse Lifr-2820M Recombinant Mouse Lifr protein, His-tagged E.coli His
    Mouse Lifr-2821M Recombinant Mouse Lifr protein, His-tagged E.coli His
    Mouse Lifr-2822M Recombinant Mouse Lifr protein, His-tagged E.coli His
    Mouse Lifr-3295M Recombinant Mouse Lifr, His-tagged Human Cell GST
    Mouse LIFR-868M Recombinant Mouse LIFR Protein, His-tagged HEK293 His
    Rat LIFR-1200RCL Recombinant Rat LIFR cell lysate Human Cell N/A
    Rat Lifr-2823R Recombinant Rat Lifr protein, His-tagged E.coli His
    Rat Lifr-2824R Recombinant Rat Lifr protein, His-tagged E.coli His
    Rat Lifr-2825R Recombinant Rat Lifr protein, His-tagged E.coli His
    Rat LIFR-3408R Recombinant Rat LIFR Protein Mammalian Cell His
    Rat Lifr-8774R Recombinant Rat Lifr, His tagged Human Cell N/A
    Chicken LIFR-6144C Recombinant Chicken LIFR Mammalian Cell His

    lifr involved in several pathways and played different roles in them. We selected most pathways lifr participated on our site, such as Cytokine-cytokine receptor interaction, Signaling pathways regulating pluripotency of stem cells, Jak-STAT signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with lifr were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL15; CXCL14; CCL28; CCR8; Il2; IL18; IL2RB; IFNE; IFNAR2; IL28RA
    Signaling pathways regulating pluripotency of stem cells PIK3CD; SMAD2; ZFHX3; Fzd4; ESX1; PIK3CG; FZD6; FZD7; SMAD5; BMP4
    Jak-STAT signaling pathway STAT2; STAT1A; PIK3CD; IL24; AKT2; CRFB4; IFNA21; IL2RB; IL7R; IFNW1

    lifr has several biochemical functions, for example, contributes_to ciliary neurotrophic factor receptor activity, ciliary neurotrophic factor receptor binding, cytokine binding. Some of the functions are cooperated with other proteins, some of the functions could acted by lifr itself. We selected most functions lifr had, and list some proteins which have the same functions with lifr. You can find most of the proteins on our site.

    Function Related Protein
    contributes_to ciliary neurotrophic factor receptor activity Il6ra; CNTFR; LIFR; IL6R
    ciliary neurotrophic factor receptor binding LIFR; CLCF1; Ctf2; IL6ST; CNTF
    cytokine binding IFNGR1; NRP1; CSF1RA; Fzd4; KITA; NRP2; ELANE; CSF1R; TNFRSF11A; CNTFR
    growth factor binding IGFBP2A; ACVR2A; IL6ST; SDCBP; KDR; IGFBP2B; RHBDF1; TEK; HTRA1A; ACVR1C
    leukemia inhibitory factor receptor activity LIFR
    contributes_to leukemia inhibitory factor receptor activity LIFR; IL6ST
    contributes_to oncostatin-M receptor activity OSMR; IL6ST; LIFR
    protein heterodimerization activity IKBKG; EFHA1; BAD; APITD1; EXT2; CEBPG; NEFH; MYF5; HIST1H3G; SNX1

    lifr has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with lifr here. Most of them are supplied by our site. Hope this information will be useful for your research of lifr.

    OSM; LIF; CNTF; PRPF4; BAG3; Bmpr1a; GOLT1B

    Sommer, J; Engelowski, E; et al. Interleukin-6, but not the interleukin-6 receptor plays a role in recovery from dextran sodium sulfate-induced colitis. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34:651-660(2014).
    Larrea, E; Echeverria, I; et al. Characterization of the CD40L/Oncostatin M/Oncostatin M receptor axis as an antiviral and immunostimulatory system disrupted in chronic HCV infection. JOURNAL OF HEPATOLOGY 60:482-489(2014).

    IL

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