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LIG3

  • Official Full Name

    ligase III, DNA, ATP-dependent

  • Overview

    This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized.
  • Synonyms

    LIG3; ligase III, DNA, ATP-dependent; LIG2, ligase II, DNA, ATP dependent; DNA ligase 3; ligase II, DNA, ATP-dependent; polydeoxyribonucleotide synthase [ATP] 3; LIG2;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human LIG3-1520H Recombinant Human LIG3 Protein, His-tagged E. coli His
Human LIG3-26931TH Recombinant Human LIG3 protein, His-tagged E.coli His
Human Lig3-26932TH Recombinant Human LIG3 protein, His-tagged E. coli His
Human LIG3-3683H Recombinant Human LIG3 protein, GST-tagged E.coli GST 254-390 aa
Human LIG3-1294H Recombinant Human LIG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human LIG3-521H Recombinant Human LIG3 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human LIG3-2567H Recombinant Human LIG3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human LIG3-3345H Recombinant Human LIG3 protein, His-tagged E.coli His 254-390 aa
Human LIG3-68H Recombinant Human LIG3 Protein, His-tagged E.coli His
Human LIG3-1294H-B Recombinant Human LIG3 Protein Pre-coupled Magnetic Beads HEK293
Human LIG3-599HFL Recombinant Full Length Human LIG3 Protein, C-Flag-tagged Mammalian cells Flag
Mouse Lig3-1319M Recombinant Mouse Lig3 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rhesus Macaque LIG3-2511R Recombinant Rhesus monkey LIG3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque LIG3-2332R Recombinant Rhesus Macaque LIG3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque LIG3-2332R-B Recombinant Rhesus Macaque LIG3 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish LIG3-3281Z Recombinant Zebrafish LIG3 Mammalian Cell His
Chicken LIG3-1363C Recombinant Chicken LIG3 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

LIG3 involved in several pathways and played different roles in them. We selected most pathways LIG3 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIG3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Base excision repairAPEX1;PARP2;mutY;POLL;POLD3;UNGA;NTHL1;MBD4;SMUG1

LIG3 has several biochemical functions, for example, ATP binding, DNA binding, DNA ligase (ATP) activity. Some of the functions are cooperated with other proteins, some of the functions could acted by LIG3 itself. We selected most functions LIG3 had, and list some proteins which have the same functions with LIG3. You can find most of the proteins on our site.

Function Related Protein
ATP bindingPRKD3;CKB;CLK2B;PAK2B;ATP12A;HSP70;DDX5;DDX41;KIF1B
DNA bindingFBXL19;POU3F2B;RFX2;TFDP2;FOXO3;RECQL;ZNF559-ZNF177;CXXC1A;ZNF669
DNA ligase (ATP) activityLIG1;LIG4;LIG3
DNA ligase activityLIG1;LIG3;LIG4
protein bindingDLAT;TMEM100;SOX13;CA8;R3HDM2;NFATC1;HGF;TRAM2;RTN3
zinc ion bindingTTF2;KDM7AB;SIRT6;NAPEPLD;MIB1;TRIM24;ADAMTS3;TRIM8;KLF4

LIG3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIG3 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIG3.

XRCC1; ABL1; SRC; PLCG1; PIK3R1; CRK; PNKP; ssdna_dtdg

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