LIPE
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Official Full Name
lipase, hormone-sensitive
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Overview
The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids. [provided by RefSeq, Jul 2008] -
Synonyms
LIPE; lipase, hormone-sensitive; HSL; LHS; hormone-sensitive lipase; hormone-sensitive lipase testicular isoform;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- E.coli
- HEK293
- HEK293T
- Insect cell
- Insect Cells
- Mammalian Cell
- Mammalian cells
- Sf21 Insect Cell
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- MYC
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- LIPE Related Articles
- LIPE Related Research Area
LIPE involved in several pathways and played different roles in them. We selected most pathways LIPE participated on our site, such as cAMP signaling pathway, AMPK signaling pathway, Insulin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIPE were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| cAMP signaling pathway | CALM4;RELA;GABBR2;MAP2K2;GRIN2A;MAPK8;PPP1CA;GHSR;GRIN2B |
| AMPK signaling pathway | Scd2;FBP1;INS2;PFKM;MAP3K7;PRKAB2;ELAVL1;RPS6KB2;EEF2 |
| Insulin signaling pathway | CALML5;CALM2A;HK3;MTOR;CBLB;EIF4E1C;FBP1;PPP1CAA;PPP1R3C |
| Regulation of lipolysis in adipocytes | INS2;GNAI2;PIK3R1;PNPLA2;AKT1;NPY;AQP7;PTGS1;PRKACG |
| Aldosterone synthesis and secretion | CALM1;AGTR1;PLCB1;CREB3L1;ATF2;ADCY6;DAGLB;PLCB4;SLC14A2 |
LIPE has several biochemical functions, for example, hormone-sensitive lipase activity, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIPE itself. We selected most functions LIPE had, and list some proteins which have the same functions with LIPE. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hormone-sensitive lipase activity | |
| protein binding | CEP57;ATN1;TSSK3;ZFP523;EXOC8;RPL22;SOX14;LCMT2;PHOSPHO2-KLHL23 |
| protein kinase binding | HSP90AB1;CEP152;CCNT2B;TEX14;CCNB1;CCNL1B;FOXO3;GSTP2;PTPRR |
| triglyceride lipase activity | CES1;PNPLA4;PNPLA3;LIPC;AADAC;LIPCA;CES5A;PNLIPRP1;CES3 |
LIPE has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIPE here. Most of them are supplied by our site. Hope this information will be useful for your research of LIPE.
NSFL1C
- Q&As
- Reviews
Q&As (7)
Ask a questionLIPE works in conjunction with other metabolic enzymes and is regulated by hormonal signals like insulin and adrenaline.
LIPE, also known as hormone-sensitive lipase, is critical for hydrolyzing stored triglycerides in fat cells.
Genetic mutations in LIPE can lead to abnormal fat metabolism, contributing to obesity and related disorders.
Altered LIPE activity can affect insulin signaling pathways, influencing the risk of diabetes.
Modulating LIPE activity could offer new treatments for obesity, diabetes, and other metabolic conditions.
It plays a key role in fat mobilization by breaking down stored fats into fatty acids for energy.
LIPE is involved in obesity and metabolic syndrome by regulating fat storage and release.
Customer Reviews (3)
Write a reviewEssential partner in our research. Accurate and timely results.
Trustworthy partner, accelerates our research progress.
Reliable data for our protein studies. Highly recommended service.
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