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Recombinant Human LIPE Protein, His-tagged

Cat.No. : LIPE-017H
Product Overview : Recombinant Human LIPE protein (2-1076) with a N-terminal His-tag was expressed in Sf21 insect cells using a baculovirus expression system
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Description : The protein encoded by this gene has a long and a short form, generated by use of alternative translational start codons. The long form is expressed in steroidogenic tissues such as testis, where it converts cholesteryl esters to free cholesterol for steroid hormone production. The short form is expressed in adipose tissue, among others, where it hydrolyzes stored triglycerides to free fatty acids.
Source : Insect Cells
Species : Human
Tag : His
Molecular Mass : 118.3 kDa
Protein length : 2-1076
Purity : ≥70% estimated by SDS-PAGE
Unit Definition : One unit is defined as the amount of enzyme required to produce 1 nmol of thioglycerol from arachidonoyl-1-thio-glycerol per minute at 37 centigrade in 10 mM Tris-HCl, pH 8.0, containing 1 mM EDTA.
Stability : ≥ 6 months
Storage : -80 centigrade
Shipping : Dry ice in continental US, may vary elsewhere.
Gene Name : LIPE lipase E, hormone sensitive type [ Homo sapiens (human) ]
Official Symbol : LIPE
Synonyms : LIPE; lipase E, hormone sensitive type; HSL; LHS; AOMS4; FPLD6; hormone-sensitive lipase; hormone-sensitive lipase testicular isoform; lipase, hormone-sensitive; EC 3.1.1.79
Gene ID : 3991
mRNA Refseq : NM_005357
Protein Refseq : NP_005348
MIM : 151750
UniProt ID : Q05469

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does LIPE interact with other enzymes and hormones in the regulation of lipid metabolism? 06/11/2022

LIPE works in conjunction with other metabolic enzymes and is regulated by hormonal signals like insulin and adrenaline.

What is the primary role of LIPE in lipid metabolism? 09/25/2021

LIPE, also known as hormone-sensitive lipase, is critical for hydrolyzing stored triglycerides in fat cells.

How do genetic variations in the LIPE gene affect its enzymatic activity and contribute to metabolic disorders? 04/22/2021

Genetic mutations in LIPE can lead to abnormal fat metabolism, contributing to obesity and related disorders.

What is the impact of altered LIPE activity on insulin resistance and diabetes? 10/09/2020

Altered LIPE activity can affect insulin signaling pathways, influencing the risk of diabetes.

What potential therapeutic applications could arise from targeting LIPE in metabolic diseases? 11/22/2019

Modulating LIPE activity could offer new treatments for obesity, diabetes, and other metabolic conditions.

How does LIPE influence the breakdown of stored fats and energy mobilization? 04/03/2018

It plays a key role in fat mobilization by breaking down stored fats into fatty acids for energy.

What role does LIPE play in obesity and metabolic syndrome? 11/24/2017

LIPE is involved in obesity and metabolic syndrome by regulating fat storage and release.

Customer Reviews (3)

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Reviews
08/16/2021

    Essential partner in our research. Accurate and timely results.

    07/29/2020

      Trustworthy partner, accelerates our research progress.

      05/05/2017

        Reliable data for our protein studies. Highly recommended service.

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