LUM
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Official Full Name
lumican
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Overview
This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair. -
Synonyms
LUM; lumican; LDC; lumican proteoglycan; SLRR2D; Keratan sulfate proteoglycan lumican; KSPG Lumican; LUM_HUMAN; Lumican precursor; OTTHUMP00000242889;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Human Cell
- In Vitro Cell Free System
- Insect Cell
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- C
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- LUM Related Articles
- LUM Related Research Area
LUM involved in several pathways and played different roles in them. We selected most pathways LUM participated on our site, such as Proteoglycans in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with LUM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Proteoglycans in cancer | HGF;MAPK13;SMAD2;PIK3CD;CBLC;TWIST1;RAC1;ACTG1;RPS6KB1 |
LUM has several biochemical functions, for example, collagen binding, extracellular matrix structural constituent, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LUM itself. We selected most functions LUM had, and list some proteins which have the same functions with LUM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| collagen binding | ASPN;ITGA1;CD44;LUM;RELL2;ANTXR1;PDGFB;SMAD7;GP5 |
| extracellular matrix structural constituent | COL24A1;MGP;KAL1;TINAGL1;FBLN2;PRELP;IMPG2;OPTC;COL5A1 |
| protein binding | MYH8;LONP1;HNRNPUL1;CCNF;TBX2A;GRB7;DDOST;NFE2L2;GDNF |
LUM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LUM here. Most of them are supplied by our site. Hope this information will be useful for your research of LUM.
MMP14; GNAQ; TRA2B; d-mannose
- Q&As
- Reviews
Q&As (5)
Ask a questionLUM is expressed in articular cartilage, muscle, intestines, kidneys and lungs.
High expression of LUM can promote gastric cancer cell invasion, migration and proliferation.
LUM is involved in regulating biological processes such as cell proliferation and migration.
LUM was highly expressed in gastric cancer cells, and its expression was significantly correlated with the depth of gastric cancer infiltration and lymph node metastasis.
LUM has been closely associated with research into diseases such as stomach, breast and pancreatic cancer.
Customer Reviews (3)
Write a reviewThe LUM proteins purchased from your company is suitable for ELISA.
Customer service was very prompt in dealing with the issue and patiently communicated with me about the details of the experiment.
The company provides one-stop service, from the purchase of products to the completion of experiments in one go.
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