MAF
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Official Full Name
v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
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Overview
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. -
Synonyms
MAF; v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian); v maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog; transcription factor Maf; c MAF; AS42 oncogene homolog; Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; Avian musculoaponeurotic fibrosarcoma (v maf); c maf proto oncogene; cMaf; MAF_HUMAN; MAF2; MGC71685; Proto oncogene c Maf; Proto-oncogene c-maf; v maf musculoaponeurotic fibrosarcoma oncogene homolog (avian); v maf musculoaponeurotic fibrosarcoma oncogene homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog; OTTHUMP00000174965; OTTHUMP00000196745; c-maf proto-oncogene; T lymphocyte c-maf long form; c-MAF;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Bacillus subtilis
- Chicken
- Human
- Mouse
- Rat
- Zebrafish
- E. coli or Yeast
- HEK293
- Mammalian Cell
- Wheat Germ
- His
- Fc
- Avi
- Non
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | MAF-26878TH | Recombinant Human MAF | Wheat Germ | Non | 100 amino acids |
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| Mouse | MAF-9435M | Recombinant Mouse MAF Protein | Mammalian Cell | His |
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| Mouse | MAF-5294M | Recombinant Mouse MAF Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Mouse | MAF-5294M-B | Recombinant Mouse MAF Protein Pre-coupled Magnetic Beads | HEK293 |
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| Rat | MAF-3532R | Recombinant Rat MAF Protein | Mammalian Cell | His |
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| Rat | MAF-3188R | Recombinant Rat MAF Protein, His (Fc)-Avi-tagged | HEK293 | His&Fc&Avi |
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| Rat | MAF-3188R-B | Recombinant Rat MAF Protein Pre-coupled Magnetic Beads | HEK293 |
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| Bacillus subtilis | MAF-0344B | Recombinant Bacillus subtilis MAF protein, His-tagged | E. coli or Yeast | His |
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| Zebrafish | MAF-9351Z | Recombinant Zebrafish MAF | Mammalian Cell | His |
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| Chicken | MAF-3463C | Recombinant Chicken MAF | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
MAF involved in several pathways and played different roles in them. We selected most pathways MAF participated on our site, such as Transcriptional misregulation in cancer, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with MAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | H3F3B;ZBTB16;PTK2;ETV4;CD14;CDK14;PBX3;RXRB;FEV |
| Inflammatory bowel disease (IBD) | HLA-DQA1;STAT3;IFNG;IL23;IL4R;RORC;IL21;SMAD2;IL13 |
MAF has several biochemical functions, for example, protein binding, sequence-specific DNA binding, transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAF itself. We selected most functions MAF had, and list some proteins which have the same functions with MAF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PYCARD;TXNRD1;OAZ3;NEGR1;AHSA1;MLLT1;CLINT1;CCND2;ATP6V1B2 |
| sequence-specific DNA binding | HOXC13A;HOXA11A;SALL3B;GCM2;DMRT2;NR2F1;NR1H3;PAX7B;HOXC6B |
| transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding | FEZF2;GATA2;ALX4;SOHLH2;PKNOX1;MSX1;BARHL2;RAD21;GATA6 |
MAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAF here. Most of them are supplied by our site. Hope this information will be useful for your research of MAF.
BACH1; HBZ; ATF4; MAFB; AHR; nusA
Research Area
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