MAF

  • Official Full Name

    v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)

  • Overview

    The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    MAF; v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian); v maf musculoaponeurotic fibrosarcoma (avian) oncogene homolog; transcription factor Maf; c MAF; AS42 oncogene homolog; Avian musculoaponeurotic fibrosarcoma (MAF) protooncogene; Avian musculoaponeurotic fibrosarcoma (v maf); c maf proto oncogene; cMaf; MAF_HUMAN; MAF2; MGC71685; Proto oncogene c Maf; Proto-oncogene c-maf; v maf musculoaponeurotic fibrosarcoma oncogene homolog (avian); v maf musculoaponeurotic fibrosarcoma oncogene homolog; V-maf musculoaponeurotic fibrosarcoma oncogene homolog; OTTHUMP00000174965; OTTHUMP00000196745; c-maf proto-oncogene; T lymphocyte c-maf long form; c-MAF;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Bacillus subtilis
  • Chicken
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E. coli or Yeast
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAF-26878TH Recombinant Human MAF Wheat Germ N/A 100 amino acids
Mouse MAF-9435M Recombinant Mouse MAF Protein Mammalian Cell His
Mouse MAF-5294M Recombinant Mouse MAF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MAF-5294M-B Recombinant Mouse MAF Protein Pre-coupled Magnetic Beads HEK293
Rat MAF-3532R Recombinant Rat MAF Protein Mammalian Cell His
Rat MAF-3188R Recombinant Rat MAF Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAF-3188R-B Recombinant Rat MAF Protein Pre-coupled Magnetic Beads HEK293
Bacillus subtilis MAF-0344B Recombinant Bacillus subtilis MAF protein, His-tagged E. coli or Yeast His
Zebrafish MAF-9351Z Recombinant Zebrafish MAF Mammalian Cell His
Chicken MAF-3463C Recombinant Chicken MAF Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MAF involved in several pathways and played different roles in them. We selected most pathways MAF participated on our site, such as Transcriptional misregulation in cancer, Inflammatory bowel disease (IBD), which may be useful for your reference. Also, other proteins which involved in the same pathway with MAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Transcriptional misregulation in cancerHIST1H3D;IL6;IL-8;Pdgfa&Pdgfb;LMO2;SSX1;MYCN;PFTK1;EWSR1
Inflammatory bowel disease (IBD)IFNGR1;TGFB1;IL18RAP;IL2RG;IL21;IFNGR2;HLA-DQA1;TLR2;IL12A

MAF has several biochemical functions, for example, protein binding, sequence-specific DNA binding, transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAF itself. We selected most functions MAF had, and list some proteins which have the same functions with MAF. You can find most of the proteins on our site.

Function Related Protein
protein bindingDHX40;POLR2A;LOH12CR1;GNAI3;KLC1;ZNF202;UBE2N;ZFPM2A;MPPED2
sequence-specific DNA bindingPAX6A;DBPB;SOX14;ZNF397;RXRAA;FOXD4;IRX1A;FOXL2;NKX1-2
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific bindingMAFGA;GATA1;GRHL3;DLX2;EP300;BARX1;NR1I2;OVOL2;ARID3A

MAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAF here. Most of them are supplied by our site. Hope this information will be useful for your research of MAF.

BACH1; HBZ; ATF4; MAFB; AHR; nusA

Research Area

Related articles

Xie, J; Cui, DW; et al. Changes in Follicular Helper T Cells in Idiopathic Thrombocytopenic Purpura Patients. INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES 11:220-229(2015).
Ma, CS; Uzel, G; et al. Human T follicular helper cells in primary immunodeficiencies. CURRENT OPINION IN PEDIATRICS 26:720-726(2014).
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