MAP2K3

  • Official Full Name

    mitogen-activated protein kinase kinase 3

  • Background

    MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAP
  • Synonyms

    MAP2K3; mitogen-activated protein kinase kinase 3; PRKMK3; dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK3; MEK3; MKK3; MEK 3; MAPKK 3;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Protein Pre-coupled Magnetic Beads
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect (sf21)
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • His|MBP
    • SUMO
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Chicken MAP2K3-2016C Recombinant Chicken MAP2K3 Mammalian Cell His
    Human MAP2K3-5595H Recombinant Human MAP2K3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAP2K3-4510HCL Recombinant Human MAP2K3 293 Cell Lysate HEK293 N/A
    Human MAP2K3-8612HF Recombinant Full Length Human MAP2K3 Protein, GST-tagged Insect (sf21) GST
    Human MAP2K3-4511HCL Recombinant Human MAP2K3 293 Cell Lysate HEK293 N/A
    Human MAP2K3-303H Recombinant Human MAP2K3 protein, His/MBP-tagged E.coli His/MBP
    Human MAP2K3-794H Recombinant Human MAP2K3, His-tagged E.coli His
    Human MAP2K3-2270H Recombinant Human MAP2K3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human MAP2K3-29204TH Recombinant Human MAP2K3, His-tagged E.coli His
    Human MAP2K3-3202H Recombinant Human MAP2K3 protein, His-SUMO-tagged E.coli His-SUMO
    Mouse MAP2K3-5324M Recombinant Mouse MAP2K3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Mouse MAP2K3-5324M-B Recombinant Mouse MAP2K3 Protein Pre-coupled Magnetic Beads HEK293
    Mouse Map2k3-3922M Recombinant Mouse Map2k3 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MAP2K3-9500M Recombinant Mouse MAP2K3 Protein Mammalian Cell His
    Rhesus Macaque MAP2K3-2484R Recombinant Rhesus Macaque MAP2K3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque MAP2K3-2664R Recombinant Rhesus monkey MAP2K3 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque MAP2K3-2484R-B Recombinant Rhesus Macaque MAP2K3 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • MAP2K3 Related Articles
    • MAP2K3 Related Research Area

    MAP2K3 involved in several pathways and played different roles in them. We selected most pathways MAP2K3 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathwayPRKACAA;FGF8;TRAF2;NTF3;MKNK2;FGF11;FGFR1;PDGFAA;FGF10
    Rap signaling pathwayPRKD3;MAP2K2;Pdgfa&Pdgfb;VEGFA;RAPGEF5;RRAS;FGF6;RAC3;IGF1
    Toll-like receptor signaling pathwayIL-8;PIK3R3;MAP2K4;Ifna15;IL12B;IRF5;IL1B;IKBKG;CCL3L3
    Fc epsilon RI signaling pathwayLAT;VAV3;IL4;HRAS;MAP2K2;PLCG1;MS4A2;FCER1A;PDPK1
    TNF signaling pathwayMAP3K7;MAP3K7IP3;CASP10;BIRC2;CXCL10;FADD;LTA;LIF;CCL2
    Inflammatory mediator regulation of TRP channelsPIK3R3;PLCB4;CYP4A14;TRPV2;PLA2G4F;CYP2J2;PLCB3;ACCN4;CAMK2A
    GnRH signaling pathwayMAP3K2;MMP14B;ITPR1;ADCY2B;CAMK2D;GRB2B;HBEGFA;MAPK11;LHBETA1
    Amyotrophic lateral sclerosis (ALS)GRIN2D;NEFM;TOMM40;TNFRSF1A;ALS2;PPP3R2;GRIN1;BCL2;GPX1
    ToxoplasmosisMAP2K6;LAMC2;CASP9;TLR2;HLA-DQA1;ALOX5;HSPA8;CASP8;PIK3R3
    Influenza ABLA;IL18;HSPA1A;MAP2K1;HLA-DOB;HLA-DQB1;ACTG1;BCL2L2-PABPN1;IFNA2
    Epstein-Barr virus infectionHLA-A;NFKBIA;YWHAG;PSMC6;POLR1D;HLA-DPA1;PSMD13;CD19;RAN

    MAP2K3 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K3 itself. We selected most functions MAP2K3 had, and list some proteins which have the same functions with MAP2K3. You can find most of the proteins on our site.

    Function Related Protein
    ATP bindingEPHA2A;CCT8L2;RFC4;CDK3;CDK10;IPPK;PFKFB4L;UHMK1;UCK1
    MAP kinase kinase activityMAP2K7;MAP3K20;MAP2K3;MAP3K14;MAPK14;MAP2K2A;MAP2K6;MAP2K2B;LRRK2
    protein bindingPSMA7;ETS1;TSSK4;ZNF559-ZNF177;UBE2Q1;MXI1;PTEN;MID1IP1;UBE2V2
    protein kinase bindingMAG;RACGAP1;JTB;MAP2K7;SKI;CALM1;TRIM6;TRAF4;TCTN2
    protein serine/threonine kinase activityIRAK2;CSNK1G1;CAMK2G1;SMOK3A;CDK16;TAOK3;GRK5;RPS6KAL;AKT1
    protein tyrosine kinase activityIGF1R;JAK2B;JAK2;PTK2BB;ALK;TTN;FYNB;SYK;WEE1

    MAP2K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K3.

    LRRK2; MAPK14; DYRK1B; TINF2; MAP3K5; MAP2K6; PKN1; MAPK14; TAOK2; MAP3K4; ALDOC; RPL13

    Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
    Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).
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