MAP2K3 Protein


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Official Full Name mitogen-activated protein kinase kinase 3
Background MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAP
Synonyms MAP2K3; mitogen-activated protein kinase kinase 3; PRKMK3; dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK3; MEK3; MKK3; MEK 3; MAPKK 3;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect (sf21)
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • His (Fc)-Avi
    • MBP
    • His-SUMO
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K3-29204TH Recombinant Human MAP2K3, His-tagged E.coli His Inquiry
    Human MAP2K3-303H Recombinant Human MAP2K3 protein, His/MBP-tagged E.coli His/MBP Inquiry
    Human MAP2K3-794H Recombinant Human MAP2K3, His-tagged E.coli His Inquiry
    Mouse MAP2K3-9500M Recombinant Mouse MAP2K3 Protein Mammalian Cell His Inquiry
    Rhesus Macaque MAP2K3-2664R Recombinant Rhesus monkey MAP2K3 Protein, His-tagged Mammalian Cell His Inquiry
    Chicken MAP2K3-2016C Recombinant Chicken MAP2K3 Mammalian Cell His Inquiry
    Human MAP2K3-4510HCL Recombinant Human MAP2K3 293 Cell Lysate HEK293 N/A Inquiry
    Human MAP2K3-4511HCL Recombinant Human MAP2K3 293 Cell Lysate HEK293 N/A Inquiry
    Rhesus Macaque MAP2K3-2484R Recombinant Rhesus Macaque MAP2K3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human MAP2K3-3202H Recombinant Human MAP2K3 protein, His-SUMO-tagged E.coli His-SUMO Inquiry
    Mouse MAP2K3-5324M Recombinant Mouse MAP2K3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human MAP2K3-8612HF Recombinant Full Length Human MAP2K3 Protein, GST-tagged Insect (sf21) GST Inquiry
    Human MAP2K3-2270H Recombinant Human MAP2K3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human MAP2K3-5595H Recombinant Human MAP2K3 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Mouse Map2k3-3922M Recombinant Mouse Map2k3 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry

    MAP2K3 involved in several pathways and played different roles in them. We selected most pathways MAP2K3 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway ARR3B; HSC70; MAPK8IP2; GNA12A; HSPA1B; NGF; CACNG7A; MAP3K4; RAF1B; HSPA2
    Rap signaling pathway HGF; MLLT4; PARD3; FGF20; FGF5; KLK1B4; GNAI1; INS; PIK3CG; GRIN1
    Toll-like receptor signaling pathway IL12B; CASP8; IFNA10; MAPK8B; IFNA6; NFKBIA; FOS; PIK3R3B; IRF5; TLR2-1
    Fc epsilon RI signaling pathway RAC2; LAT; TNF; FCER1A; MAP2K4; MAPK10; PDPK1; MAP2K2; PIK3R3; MAPK13
    TNF signaling pathway PIK3R3; VCAM1; CREB3L3; MAGI2; TRAF1; MAPK9; IKBKG; BIRC2; ITCH; CXCL5
    Inflammatory mediator regulation of TRP channels CYP2C37; CYP4A10; ACCN5; TRPV2; TRPV1; MAPK10; CALM3; ASIC3; PIK3R3; PIK3R1
    GnRH signaling pathway PLCB2; MMP2; CACNA1D; MAPK3; CALM1A; CAMK2G; MAPK1; CALM1; CALM4; GNA15.1
    Amyotrophic lateral sclerosis (ALS) BAD; CAT; GRIN2C; MAP3K5; MAP2K6; TOMM40L; BCL2; CASP12; ALS2; PRPH
    Toxoplasmosis TNF; PIK3R1; CYCS; HSPA8; HLA-DQA2; HLA-DQA1; MAPK10; IRAK1; LAMB2; LAMA2
    Influenza A PIK3CG; MAP2K4; TMPRSS4; RAF1; IFNA6; CYCS; IFNA12; NXT1; CXCL8; Fasl
    Epstein-Barr virus infection POLR2E; TAB2; HLA-G; EIF2AK3; EIF2AK1; CR2; CD44; PSMC1; ENTPD3; HLA-DQB1

    MAP2K3 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K3 itself. We selected most functions MAP2K3 had, and list some proteins which have the same functions with MAP2K3. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding TYRO3; TTN; MYH11; VARS2; EPHB3A; DCLK3; MCM3; ATP2A2A; NUBP1; PSMC2
    MAP kinase kinase activity ALPK2; MAP3K14; MAP2K3; MAP2K2B; MAPK14; MAP3K20; LRRK2; MAP2K1; MAP2K7; MAP2K2
    protein binding CD8B; FAM83A; HMGCR; GINS2; FYTTD1; FBXL12; TPCN2; SH3BP4; CD200R2; MASP2
    protein kinase binding MAP2K3; ACTA2; PTPN23; PGAM1; ADIPOR1; CDH2; MAP2K7; KIF13B; TSACC; ACSL3
    protein serine/threonine kinase activity PLK1; NEK8; CDC42BPG; ROCK2; DCLK3; ULK1A; STK35; GM4922; MAPK14; PRPF4B
    protein tyrosine kinase activity FGFR3; INSRA; KIT; PDGFRB; PTK2BB; KITA; AXL; TYK2; PTK7; Fert2

    MAP2K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K3.


    Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).

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