map2k3
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  • Official Full Name
  • mitogen-activated protein kinase kinase 3
  • Background
  • MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAP
  • Synonyms
  • MAP2K3; mitogen-activated protein kinase kinase 3; PRKMK3; dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK3; MEK3; MKK3; MEK 3; MAPKK 3
Cat.#:MAP2K3-29204THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K3, His-tagged
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Cat.#:MAP2K3-303HTag:His|MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K3 protein, His/MBP-tagged
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Cat.#:MAP2K3-9500MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MAP2K3 Protein
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Cat.#:MAP2K3-2664RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey MAP2K3 Protein, His-tagged
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Cat.#:MAP2K3-2016CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MAP2K3
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Cat.#:MAP2K3-794HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MAP2K3, His-tagged
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Cat.#:MAP2K3-4510HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAP2K3 293 Cell Lysate
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Cat.#:MAP2K3-4511HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human MAP2K3 293 Cell Lysate
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Involved Pathway

MAP2K3 involved in several pathways and played different roles in them. We selected most pathways MAP2K3 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
MAPK signaling pathway
PRKCG; FGF9; SRF; FGF4; FGF6; RPS6KA4; TNFRSF1A; MAP4K4; MAX; HRAS
Rap signaling pathway
ITGB2L; RRAS; FGF21; PFN1; VEGFC; PRKD2; FGFR4; ITGAL; KITLG; RAPGEF1
Toll-like receptor signaling pathway
TNF; IL6; CCL5; MAP2K2; Ifna15; CCL3L3; FOS; PIK3CD; TAB2; TLR2
Fc epsilon RI signaling pathway
AKT1; MAPK1; LYN; SOS1; VAV2; NRAS; LAT; MAP2K1; IL3; PIK3CA
TNF signaling pathway
TRAF1; PTGS2; CREB3L1; MAPK11; MAP2K3; TRAF2; ICAM1; NFKB1; MMP3; CASP8
Inflammatory mediator regulation of TRP channels
PIK3R2; IL1RAP; MAPK10; BDKRB1; PIK3R5; ASIC2; MAPK12; CYP2C39; CYP2J2; TRPV3
GnRH signaling pathway
PRKACBA; MAPK3; CALM4; CAMK2B1; PLA2G4A; MAPK7; GNRHR1; MAPK10; ITPR3; PLCB3
Amyotrophic lateral sclerosis (ALS)
GRIN1; BID; TNFRSF1B; PPP3R2; NEFH; BCL2L1; RAC1; GPX1; BAX; DERL1
Toxoplasmosis
IFNGR1; BAD; SOCS1; BCL2L1; TAB2; IFNGR2; HLA-DMA; LAMA1; ITGA6; MAP3K7
Influenza A
HLA-DPB1; MAP2K7; ACTG1; PIK3CA; NUP98; IRF3; IFNA7; IFNA21; MAVS; KPNA2
Epstein-Barr virus infection
GTF2E1; MAP2K6; HLA-B; MAP2K7; CDK1; PSMD7; EIF2AK2; POLR2H; PSMC1; HSPA1L

Protein Function

MAP2K3 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K3 itself. We selected most functions MAP2K3 had, and list some proteins which have the same functions with MAP2K3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein DCK; PGK2; NAIP6; PAK1; FIGNL1; MYH4; AK7B; MYHC4; PLK4; WEE1
Function MAP kinase kinase activity
Related Protein MAPK14; MAP3K20; MAP3K9; MAP2K2; MAP2K2B; LRRK2; MAP2K3; SBK3; ALPK2; PAK3
Function protein binding
Related Protein GRIN1; PPP2R2C; E2F2; THOC4; CCNF; CHCHD3; NFU1; LRP6; LMO2; HSPA1B
Function protein kinase binding
Related Protein EEF1A1; Cd24a; CD8A; PLK1; PARP1; CCNYL1; CCNL1B; FBXO7; CYLD; BCL10
Function protein serine/threonine kinase activity
Related Protein HIPK1; LIMK2; HIPK2; DCLK1; DCLK1A; CAMK2G1; SIK2; PRPF4B; VRK3; TAF1L
Function protein tyrosine kinase activity
Related Protein FGFR3; EPHA4A; FGFR1; PTK7A; DYRK1A; EPHA2A; WEE1; FGFR1OP; IGF1R; KITB

Interacting Protein

MAP2K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K3.
LRRK2; MAPK14; DYRK1B; TINF2; MAP3K5; MAP2K6; PKN1; MAPK14; TAOK2; MAP3K4; ALDOC; RPL13

MAP2K3 Related Articles

Sharaf, H; Matou-Nasri, S; et al. Advanced glycation endproducts increase proliferation, migration and invasion of the breast cancer cell line MDA-MB-231. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 1852:429-441(2015).
Wang, R; Yang, J; et al. GARDENAMIDE A ATTENUATED CELL APOPTOSIS INDUCED BY SERUM DEPRIVATION INSULT VIA THE ERK1/2 AND PI3K/AKT SIGNALING PATHWAYS. NEUROSCIENCE 286:242-250(2015).