MAP2K3
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Official Full Name
mitogen-activated protein kinase kinase 3
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Overview
MKK3 and MKK6 are two closely related dual-specificity protein kinases that activate p38 MAP kinase (1-5). MKK3 and MKK6 both phosphorylate and activate p38 MAP kinase at its activation site, Thr-Gly-Tyr, but do not phosphorylate or activate Erk1/2 or SAP -
Synonyms
MAP2K3; mitogen-activated protein kinase kinase 3; PRKMK3; dual specificity mitogen-activated protein kinase kinase 3; dual specificity mitogen activated protein kinase kinase 3; MAP kinase kinase 3; MAPK/ERK kinase 3; MAPKK3; MEK3; MKK3; MEK 3; MAPKK 3;
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MAP2K3 involved in several pathways and played different roles in them. We selected most pathways MAP2K3 participated on our site, such as MAPK signaling pathway, Rap signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | RPS6KA6;CACNG4;GADD45G;PPM1AB;TGFBR2;MAPK8B;CACNG2A;RRAS2;MEF2CA |
| Rap signaling pathway | F2R;PIK3R3;MAP2K3;ITGB3;MAGI1;PRKD2;PRKCZ;DOCK4;CALM2 |
| Toll-like receptor signaling pathway | IFNPHI3;MAP2K1;IKBKG;IFNA17;TLR4BB;IL12BA;TRAF3;AKT2;CCL4L2 |
| Fc epsilon RI signaling pathway | IL4;PLA2G4D;FCER1A;LCP2;MAPK3;NRAS;MAPK12;PLA2G4A;KRAS |
| TNF signaling pathway | CCL2;CXCL1;CCL5;RPS6KA5;TAB2;PIK3CB;PTGS2;MAPK9;MMP9 |
| Inflammatory mediator regulation of TRP channels | BDKRB2;ASIC3;PRKCE;ACCN4;PIK3R1;GNAQ;IL1RAP;PLA2G4A;IL1B |
| GnRH signaling pathway | MAPK9;RAF1;MAPK7;HRAS;PLD1;GNA11;CALM2B;CALML3;CALML5 |
| Amyotrophic lateral sclerosis (ALS) | BAX;TP53;TNF;TOMM40;CYCS;TNFRSF1A;GRIN2A;MAPK13;GPX1 |
| Toxoplasmosis | HLA-DQA1;MAPK1;LAMB2;AKT1;HSPA6;IL12B;PPIF;IL10RB;IL10RA |
| Influenza A | RSAD2;EIF2AK1;PLG;IFNA10;EIF2AK3;KPNA1;EP300;MAP2K6;TRIM25 |
| Epstein-Barr virus infection | TNFAIP3;TBK1;POLR2E;POLR2D;PRKACB;POLR2F;PSMD1;TBP;STAT3 |
MAP2K3 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K3 itself. We selected most functions MAP2K3 had, and list some proteins which have the same functions with MAP2K3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ASNS;ATRX;ABCG2C;DYNC1LI2;CLPXA;SHPK;FKBP4;DCLK2;KIF6 |
| MAP kinase kinase activity | SBK3;MAP2K2B;PAK3;MAP3K9;LRRK2;ALPK2;MAP2K7;MAPK14;MAP2K1 |
| protein binding | MALL;Car4;KIF1C;PPP1R3C;NAMPT;TRAPPC10;C12orf40;RPL4;SCNN1G |
| protein kinase binding | CCND3;SPRY2;JTB;FAM83D;B4GALT1;PLCG1;CEP68;CCNB1;MAPKAP1 |
| protein serine/threonine kinase activity | HIPK3;SQSTM1;PRKCI;CAMKK1A;SIK2A;KSR2;LATS1;CSNK1DB;WNK1 |
| protein tyrosine kinase activity | MAP2K5;TYRO3;TNK2;ERBB4;IGF1R;Fert2;DYRK4;LCK;EPHB3A |
MAP2K3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K3 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K3.
LRRK2; MAPK14; DYRK1B; TINF2; MAP3K5; MAP2K6; PKN1; MAPK14; TAOK2; MAP3K4; ALDOC; RPL13
Research Area
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Customer Reviews (3)
Write a reviewThe manufacturer's commitment to customer satisfaction extends beyond providing the protein itself.
They offer comprehensive technical support, including responsive customer service, availability of product information, and timely delivery of the product.
MAP2K3 protein offers numerous advantages in trials, ranging from its stability and bioactivity to the manufacturer's commitment to customer support.
Q&As (5)
Ask a questionEvidence suggests that MAP2K3 expression levels can correlate with disease prognosis, aiding in predicting outcomes for some cancers.
Clinical trials investigating the efficacy of targeting MAP2K3 in cancer treatments are underway, assessing its potential as a therapeutic target.
MAP2K3 dysregulation has been observed in various cancers, including colorectal, lung, and breast cancers.
While specific inhibitors for MAP2K3 are under development, some drugs indirectly impact its activity by targeting related proteins in the signaling cascade.
Expression levels of MAP2K3 can be assessed through techniques like immunohistochemistry or molecular analyses in patient samples.
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