MAP2K7

  • Official Full Name

    MAP2K7 mitogen-activated protein kinase kinase 7
  • Overview

    The stress response of mammalian cells results in activation of kinases of the SAPK1 and SAPK2 families. The SAP kinases are specifically activated by dual phosphorylation of a conserved T-X-Y motif by MAP kinase kinases (MKK). The 3 isoforms of the SAPK1 family (SAPK1 alpha/jnk2; SAPK1 beta/jnk3; SAPK1 beta/jnk1) are synergistically activated by phosphorylation of the threonine residue by MKK7 and the tyrosine residue by MKK4.
  • Synonyms

    MAP2K7;mitogen-activated protein kinase kinase 7;PRKMK7;dual specificity mitogen-activated protein kinase kinase 7;Jnkk2;MKK7;MEK 7;JNKK 2;MAPKK 7;SAPK kinase 4;MAPK/ERK kinase 7;MAP kinase kinase 7;JNK-activating kinase 2;c-Jun N-terminal kinase kinase 2;stress-activated protein kinase kinase 4;MAPKK7;SAPKK4;SAPKK-4

Recombinant Proteins

  • Human
  • Rat
  • Zebrafish
  • Mouse
  • E.coli
  • Mammalian Cells
  • HEK293
  • Insect Cells
  • Sf21 Cells
  • His
  • T7
  • Non
  • GST
  • Avi
  • Fc
  • Flag
  • DDK
  • Myc
Cat.# Product name Source (Host) Species Tag Protein Length Price
MAP2K7-8083H Recombinant Human MAP2K7 protein, His & T7-tagged E.coli Human His&T7 Tyr113~Val388
MAP2K7-3562R Recombinant Rat MAP2K7 Protein Mammalian Cells Rat His
MAP2K7-7761Z Recombinant Zebrafish MAP2K7 Mammalian Cells Zebrafish His
Map2k7-8084M Recombinant Mouse Map2k7 protein, His & T7-tagged E.coli Mouse His&T7 Met181~His429
MAP2K7-9504M Recombinant Mouse MAP2K7 Protein Mammalian Cells Mouse His
MAP2K7-4508HCL Recombinant Human MAP2K7 293 Cell Lysate HEK293 Human Non
MAP2K7-0394H Recombinant Human MAP2K7 Protein (A2-R419), Tag Free Insect Cells Human Non A2-R419
MAP2K7-0395H Recombinant Human MAP2K7 Protein (A2-R419), His/GST tagged Insect Cells Human GST&His A2-R419
MAP2K7-1356H Recombinant Human MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
MAP2K7-1356H-B Recombinant Human MAP2K7 Protein Pre-coupled Magnetic Beads HEK293 Human
MAP2K7-1511HFL Recombinant Full Length Human MAP2K7 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
MAP2K7-2337HF Active Recombinant Full Length Human MAP2K7 Protein, GST-tagged Sf21 Cells Human GST Full L. 1-419(end)
MAP2K7-3218R Recombinant Rat MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
MAP2K7-3218R-B Recombinant Rat MAP2K7 Protein Pre-coupled Magnetic Beads HEK293 Rat
MAP2K7-3775HF Active Recombinant Full Length Human MAP2K7 Protein, GST-tagged E.coli Human GST Full L. 1-419(end)
Map2k7-3925M Recombinant Mouse Map2k7 Protein, Myc/DDK-tagged HEK293 Mouse DDK&Myc
MAP2K7-4603HF Active Recombinant Full Length Human MAP2K7 Protein, GST-tagged Sf21 Cells Human GST Full L. 1-419(end)
MAP2K7-5009H Recombinant Human MAP2K7 Protein (Thr103-Arg419), N-His tagged E.coli Human His Thr103-Arg419
MAP2K7-5327M Recombinant Mouse MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
MAP2K7-5327M-B Recombinant Mouse MAP2K7 Protein Pre-coupled Magnetic Beads HEK293 Mouse
MAP2K7-8085H Recombinant Human MAP2K7 Protein, GST-tagged Insect Cells Human GST

    Involved Pathway

    MAP2K7 involved in several pathways and played different roles in them. We selected most pathways MAP2K7 participated on our site, such as MAPK signaling pathway,ErbB signaling pathway,Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Toll-like receptor signaling pathway MAP2K4B,IFNA10,CD14,IL8L1,IFNPHI3,MAPK10,AKT1,TNF,CCL4L1,MAPK8A
    Osteoclast differentiation FCGR3B,FOSL1,CSF1,IFNGR1,IFNAR1,FOS,LCP2,IKBKG,IFNB1,PIK3CB
    Influenza A IL1B,NFKBIB,DNAJB1,TNF,Ifna11,STAT2,IFNGR1,IFNA7,IFNGR2,BCL2L2-PABPN1
    Neurotrophin signaling pathway PIK3CB,RELA,TP53,TP73,PIK3CA,ARHGDIA,NGFR,MAP2K2,PIK3CG,BDNF
    Epstein-Barr virus infection POLR2A,PIK3R1,PLCG2,HSPA1B,SFPI1,GTF2E2,HLA-DRA,VIM,BCL2,NFKBIE
    GnRH signaling pathway PRKACB,MAP2K2B,CAMK2D,GRB2B,HRAS,PLA2G4C,CDC42L2,PLA2G4A,GNAQ,MAPK9
    MAPK signaling pathway PLA2G4F,PRKCB,FAS,HSPB1,MAP3K2,RAC1B,PRKCA,NF1,NTF4,ARR3B
    Protein processing in endoplasmic reticulum SEC24C,BCAP31,BAK1,MAPK9,SEC31A,UBE2D4,DNAJB2,UBE2D2,DNAJC1,MBTPS1
    T cell receptor signaling pathway PAK6,PIK3R1,IKBKB,PAK3,PDCD1,OXSR1A,PAK2,CD3D,NCK2,GRB2

    Protein Function

    MAP2K7 has several biochemical functions, for example, ATP binding,MAP kinase kinase activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K7 itself. We selected most functions MAP2K7 had, and list some proteins which have the same functions with MAP2K7. You can find most of the proteins on our site.

    Function Related Protein
    enzyme binding CD4,RARA,ERN1,BRCA1,PHB,UGT1A7,ABCD1,UGT1A1,DDC,HSPA6
    protein serine/threonine kinase activity STK19,NEK1,PRKCQ,SLK,PLK1,RAF1B,SRPK3,CAMK1GA,ALPK2,TAOK2
    protein binding TJP1,ZNF821,FSHB,ANO2,DDX39A,AHSA2,CEACAM21,ARPIN,WIF1,FRK
    protein phosphatase binding CDC27,VCAN,FLT4,SNX3,IRS2,ROS1,ANAPC5,TRP53,AP3B1,KCNN4
    MAP kinase kinase activity MAP3K9,MAP2K2B,MAPK10,ALPK2,MAP3K20,SBK3,MAPKAPK5,MAPK14,MAP2K3,MAP3K14
    magnesium ion binding STK11,CDC42BPG,MAST2,MAST4,ATP8B3,PKMB,TSSK2,STK4,OPA1,GSS
    protein tyrosine kinase activity TESK1,DYRK3,MAP2K1,PTK2BB,BLK,DYRK2,IGF1RB,KIAA1804,PDGFRB,KDRL
    protein kinase binding ACVRL1,CHEK2,CD4,CAV2,SLC12A7,MAP3K12,GPRC5B,KIF11,PEBP1,HSPB1
    ATP binding PIK3C3,MAP2K1,DDX28,RIPK2,TIMM44,MAP3K6,NME4,NADK,TNK2B,CKB

    Interacting Protein

    MAP2K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K7.

    MAP3K7;(dtp3)-tyr,arg,phe;GADD45B;MAPK8IP1

    Resources

    References

    • Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
    • Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).

    Ask a Question for All MAP2K7 Products

    Required fields are marked with *

    My Review for All MAP2K7 Products

    Required fields are marked with *