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Official Full Name MAP2K7 mitogen-activated protein kinase kinase 7
Background The stress response of mammalian cells results in activation of kinases of the SAPK1 and SAPK2 families. The SAP kinases are specifically activated by dual phosphorylation of a conserved T-X-Y motif by MAP kinase kinases (MKK). The 3 isoforms of the SAPK1 family (SAPK1 alpha/jnk2; SAPK1 beta/jnk3; SAPK1 beta/jnk1) are synergistically activated by phosphorylation of the threonine residue by MKK7 and the tyrosine residue by MKK4.
Synonyms MAP2K7; mitogen-activated protein kinase kinase 7; PRKMK7; dual specificity mitogen-activated protein kinase kinase 7; Jnkk2; MKK7; MEK 7; JNKK 2; MAPKK 7; SAPK kinase 4; MAPK/ERK kinase 7; MAP kinase kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4; MAPKK7; SAPKK4; SAPKK-4;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K7-8085H Recombinant Human MAP2K7 Protein, GST-tagged Insect cell GST
    Human MAP2K7-4508HCL Recombinant Human MAP2K7 293 Cell Lysate HEK293 N/A
    Human MAP2K7-8083H Recombinant Human MAP2K7 protein, His & T7-tagged E.coli His/T7
    Mouse Map2k7-8084M Recombinant Mouse Map2k7 protein, His & T7-tagged E.coli His/T7
    Mouse MAP2K7-9504M Recombinant Mouse MAP2K7 Protein Mammalian Cell His
    Rat MAP2K7-3562R Recombinant Rat MAP2K7 Protein Mammalian Cell His
    Zebrafish MAP2K7-7761Z Recombinant Zebrafish MAP2K7 Mammalian Cell His

    map2k7 involved in several pathways and played different roles in them. We selected most pathways map2k7 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with map2k7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway CACNA2D3; HSC70; MOS; MAPT; MAPK8; MAP4K1; TNF; CDC42L2; TGFB1; TGFB2
    ErbB signaling pathway AKT2; CAMK2G; MAP2K4B; CAMK2A; EGFRA; CAMK2B; AKT3A; NCK2B; TGFA; MAPK9
    Protein processing in endoplasmic reticulum ATF6; ATXN3; HSP70L; ATXN3L; FBXO6; SSR1; TRAF2; ERLEC1; GANAB; RNF185
    Osteoclast differentiation LILRB4; ITGB3; CALCR; FCGR1; TYK2; FCGR3B; AKT1; TNFRSF11B; LILRA2; IFNAR1
    Toll-like receptor signaling pathway IFNA16; RAC1B; TBK1; IFNA1; PIK3CD; IFNA17; TLR5; CCL4L1; NFKBIAA; CRFB2
    T cell receptor signaling pathway PPP3CA; PIK3CG; NFATC3; IKBKG; NCK2; FOS; NFATC2; VAV3; PPP3R2; BCL10
    Fc epsilon RI signaling pathway BTK; VAV1; PIK3R3; RAF1; MAP2K3; MAPK3; MAP2K4; PDPK1; INPP5D; LCP2
    TNF signaling pathway MLKL; FAS; TNFAIP3; ITCH; Ccl12; RPS6KA5; ICAM1; SOCS3; IL18R1; CASP8
    Neurotrophin signaling pathway NTF4; ARHGDIG; CALM1; NRAS; RPS6KA3; YWHAE; RPS6KA1; MAPK12; MATK; RAF1
    GnRH signaling pathway GNRHR1; CGNRH-R; PLD1A; PLCB3; CALM3B; MAP2K2A; GNRHR; PLA2G4AA; HRAS; MAPK10
    Influenza A IFNA8; MAPK10; RSAD2; IRF9; TNFRSF10D; HSPA2; BLA; FAS; IFNAR1; NXF2
    Epstein-Barr virus infection HLA-G; PIK3R5; PRKACA; CD58; ENTPD3; EIF2AK4; YWHAE; MAPK11; NFKBIA; PSMC5

    map2k7 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by map2k7 itself. We selected most functions map2k7 had, and list some proteins which have the same functions with map2k7. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase activity MAPKAPK5; MAPK10; LRRK2; MAP3K14; MAP2K6; MAP3K9; MAP2K7; SBK3; MAP2K2A; MAP3K20
    enzyme binding EGLN1; TH; PLSCR1; LDB1; UBE2I; PRKCE; HIST1H2AM; RFC5; APP; PLCE1
    magnesium ion binding CERK; PRPS1; ADPRHL1; SRPK1; Atp8a2; PPM1NB; NUDT18; ATP9A; ATP4A; ENO3
    protein binding TBPL1; BCL2L1; PLXDC1; PRKDC; SELENBP1; NUP205; MYL12A; TXNL4B; IL15; RTP4
    protein kinase binding MAVS; MLKL; CD24; TRIB3; SV2A; LSM2; CDKN2C; ACTA2; PRC1; WAS
    protein phosphatase binding GNB2L1; KCNN4; MVP; TRAF3; ERBB2; LCK; STAT3; CSK; IRS2; NEK2
    protein serine/threonine kinase activity PAK2; CSNK1A1; TAF1; CSNK1G2; MAP3K10; PDIK1L; PRKD2; CDK15; MINK1; CAMK1GB
    protein tyrosine kinase activity EK1; SRC; EGFR; CLK2; MAP2K2; FGFR1OP; TEK; BLK; CSK; MAP2K1

    map2k7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with map2k7 here. Most of them are supplied by our site. Hope this information will be useful for your research of map2k7.

    MAP3K7; (dtp3)-tyr,arg,phe; GADD45B; MAPK8IP1

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).

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