MAP2K7 Protein


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Official Full Name MAP2K7 mitogen-activated protein kinase kinase 7
Background The stress response of mammalian cells results in activation of kinases of the SAPK1 and SAPK2 families. The SAP kinases are specifically activated by dual phosphorylation of a conserved T-X-Y motif by MAP kinase kinases (MKK). The 3 isoforms of the SAPK1 family (SAPK1 alpha/jnk2; SAPK1 beta/jnk3; SAPK1 beta/jnk1) are synergistically activated by phosphorylation of the threonine residue by MKK7 and the tyrosine residue by MKK4.
Synonyms MAP2K7; mitogen-activated protein kinase kinase 7; PRKMK7; dual specificity mitogen-activated protein kinase kinase 7; Jnkk2; MKK7; MEK 7; JNKK 2; MAPKK 7; SAPK kinase 4; MAPK/ERK kinase 7; MAP kinase kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4; MAPKK7; SAPKK4; SAPKK-4;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect (sf21)
    • Insect cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K7-8083H Recombinant Human MAP2K7 protein, His & T7-tagged E.coli His/T7
    Mouse Map2k7-8084M Recombinant Mouse Map2k7 protein, His & T7-tagged E.coli His/T7
    Mouse MAP2K7-9504M Recombinant Mouse MAP2K7 Protein Mammalian Cell His
    Rat MAP2K7-3562R Recombinant Rat MAP2K7 Protein Mammalian Cell His
    Zebrafish MAP2K7-7761Z Recombinant Zebrafish MAP2K7 Mammalian Cell His
    Human MAP2K7-4508HCL Recombinant Human MAP2K7 293 Cell Lysate HEK293 N/A
    Human MAP2K7-2337HF Recombinant Full Length Human MAP2K7 Protein, GST-tagged Insect (sf21) GST
    Human MAP2K7-3775HF Recombinant Full Length Human MAP2K7 Protein, GST-tagged E.coli GST
    Human MAP2K7-4603HF Recombinant Full Length Human MAP2K7 Protein, GST-tagged Insect (sf21) GST
    Human MAP2K7-8085H Recombinant Human MAP2K7 Protein, GST-tagged Insect cell GST
    Mouse Map2k7-3925M Recombinant Mouse Map2k7 Protein, Myc/DDK-tagged HEK293T Myc/DDK

    MAP2K7 involved in several pathways and played different roles in them. We selected most pathways MAP2K7 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway NR4A1; CACNA2D2; FGF16; AKT1; FGFR4; BRAF; MAP2K3; FASLG; TGFB3; MAPK8
    ErbB signaling pathway PAK2A; CAMK2B; CAMK2D; MAPK8A; CBLB; HRAS; PTK2; KRAS; NCK2A; PAK7
    Protein processing in endoplasmic reticulum SEC24D; UBQLN1; STT3A; ATF6; UBXN6; SEC31A; ERLEC1; TUSC3; DERL1; SVIP
    Osteoclast differentiation TRAF6; SIRPG; FCGR4; LILRA5; LILRA3; ACP5; AKT1; NCF4; PIK3R1; SYK
    Toll-like receptor signaling pathway TLR1; IFNA8; IFNA16; IFNA12; CXCL9; IFNAR1; TLR2-1; IFNA3; CD80; MAP2K2
    T cell receptor signaling pathway FYN; PPP3R2; IKBKB; CBLB; VAV1; BCL10; PAK2; PRKCQ; GSK3B; SOS1
    Fc epsilon RI signaling pathway INPP5D; PIK3CA; LAT; PRKCA; FYN; PIK3CB; VAV1; GM-CSF; MS4A2; NRAS
    TNF signaling pathway BAG4; CASP8; NFKB1; MAPK13; TRAF5; TRAF2; MAPK9; CX3CL1; VCAM1; CREB3L1
    Neurotrophin signaling pathway MAP2K1; ATF4; CALML5; PRDM4; ARHGDIB; CALM4; RPS6KA3; MAGED1; CAMK2B; RPS6KA6
    GnRH signaling pathway MAP2K1; CALM1A; MAP2K2B; NRAS; GNRHR2; MAPK14B; ITPR3; CAMK2B; CACNA1DA; GRB2B
    Epstein-Barr virus infection CCNA2; HLA-B; POLR3C; PSMC6; RIPK1; TAB2; FGR; SFPI1; IRF3; HLA-A

    MAP2K7 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K7 itself. We selected most functions MAP2K7 had, and list some proteins which have the same functions with MAP2K7. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding CCC2; UBE2G2; HARS; ACVR1B; STK17A; RFC5; DHX32A; TAOK1; UBE2O; SCYL2
    MAP kinase kinase activity MAP2K7; ALPK2; MAP2K1; MAP3K20; MAP2K2; MAP3K14; MAPKAPK5; PAK3; MAP2K2B; MAP2K2A
    enzyme binding UGT1A3; PCCA; SLPI; SELS; NPM2; CCND1; PCBP2; PTPLA; HDAC10; KIAA1967
    magnesium ion binding MAP3K6; PPA2; FIGNL1; ABL2; IDH3A; RPS6KA3; NUDT7; BPNT1; RPS6KA2; PI4K2A
    protein binding VPS54; TOR1AIP1; LBX1; DHH; DDX41; R3HDM2; FAM46C; BCAS2; SEC23A; TBC1D5
    protein kinase binding CCND1; FAM83D; PLK1S1; STK39; PDCD10; RAB8A; TRAF2; TEX14; HDAC7; KCNQ3
    protein phosphatase binding PPP1R3C; EGFR; DLG4; PARD3; VCAN; EIF2AK3; TP53; PIK3R1; PIK3R2; FGF19
    protein serine/threonine kinase activity CDC7; ILK; ULK4; PDPK1; RPS6KA2; PAK3; MAP4K1; STK32C; CAMKK1B; PRKCZ
    protein tyrosine kinase activity TNK2B; JAK2A; EPHA4B; KDRL; LCK; KIAA1804; DYRK3; FYNB; MUSK; DYRK4

    MAP2K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K7.

    MAP3K7; (dtp3)-tyr,arg,phe; GADD45B; MAPK8IP1

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).

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