• Official Full Name

    MAP2K7 mitogen-activated protein kinase kinase 7

  • Background

    The stress response of mammalian cells results in activation of kinases of the SAPK1 and SAPK2 families. The SAP kinases are specifically activated by dual phosphorylation of a conserved T-X-Y motif by MAP kinase kinases (MKK). The 3 isoforms of the SAPK1 family (SAPK1 alpha/jnk2; SAPK1 beta/jnk3; SAPK1 beta/jnk1) are synergistically activated by phosphorylation of the threonine residue by MKK7 and the tyrosine residue by MKK4.
  • Synonyms

    MAP2K7; mitogen-activated protein kinase kinase 7; PRKMK7; dual specificity mitogen-activated protein kinase kinase 7; Jnkk2; MKK7; MEK 7; JNKK 2; MAPKK 7; SAPK kinase 4; MAPK/ERK kinase 7; MAP kinase kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4; MAPKK7; SAPKK4; SAPKK-4;
    • Type:
    • Protein Pre-coupled Magnetic Beads
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cell
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • His (Fc)
    • Avi
    • His|T7
    • Myc
    • DDK
    • N/A
    • No tag
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K7-1356H-B Recombinant Human MAP2K7 Protein Pre-coupled Magnetic Beads HEK293
    Human MAP2K7-8085H Recombinant Human MAP2K7 Protein, GST-tagged Insect cell GST
    Human MAP2K7-8083H Recombinant Human MAP2K7 protein, His & T7-tagged E.coli His/T7
    Human MAP2K7-4508HCL Recombinant Human MAP2K7 293 Cell Lysate HEK293 N/A
    Human MAP2K7-1356H Recombinant Human MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Human MAP2K7-0395H Recombinant Human MAP2K7 Protein (A2-R419), His/GST tagged Insect Cell His/GST
    Human MAP2K7-0394H Recombinant Human MAP2K7 Protein (A2-R419), Tag Free Insect Cell No tag
    Mouse Map2k7-3925M Recombinant Mouse Map2k7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse MAP2K7-5327M-B Recombinant Mouse MAP2K7 Protein Pre-coupled Magnetic Beads HEK293
    Mouse MAP2K7-9504M Recombinant Mouse MAP2K7 Protein Mammalian Cell His
    Mouse Map2k7-8084M Recombinant Mouse Map2k7 protein, His & T7-tagged E.coli His/T7
    Mouse MAP2K7-5327M Recombinant Mouse MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat MAP2K7-3218R Recombinant Rat MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat MAP2K7-3562R Recombinant Rat MAP2K7 Protein Mammalian Cell His
    Rat MAP2K7-3218R-B Recombinant Rat MAP2K7 Protein Pre-coupled Magnetic Beads HEK293
    Zebrafish MAP2K7-7761Z Recombinant Zebrafish MAP2K7 Mammalian Cell His
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • MAP2K7 Related Articles

    MAP2K7 involved in several pathways and played different roles in them. We selected most pathways MAP2K7 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    ErbB signaling pathwayMAP2K2;EGFRA;SHC2;CAMK2D;SRC;PIK3R3B;ERBB2;AKT2L;PIK3CB
    Protein processing in endoplasmic reticulumHSP90AA1;MAPK10;MAN1C1;PDIA6;CUL1A;SEC24B;SIL1;PRKCSH;HYOU1
    Osteoclast differentiationACP5;LILRA5;IL1A;PPARG;SIRP-BETA;TYROBP;PIK3R2;SIRPG;TEC
    Toll-like receptor signaling pathwayMAPK14A;LBP;IFNA10;MAPK10;IFNA21;CXCL8B.3;TLR1LB;MAP2K6;IKBKE
    T cell receptor signaling pathwayCD4;PPP3R2;CD40LG;MAP2K2;NFATC2;PIK3CG;PAK6;ZAP70;GRB2
    Fc epsilon RI signaling pathwayIL4;PLCG1;AKT1;PLA2G4D;PRKCA;LYN;MAP2K7;MAPK11;NRAS
    TNF signaling pathwayLIF;MAP3K14;CFLAR;CASP7;PIK3R3;RIPK1;BIRC3;IL15;MAPK3
    Neurotrophin signaling pathwayCALML5;PIK3CG;NFKBIB;MAPK13;SH2B1;RPS6KA2;GSK3B;RHOA;CALM4
    Epstein-Barr virus infectionPOLR3E;PSMD3;ICAM1;YWHAZ;CR2;TNFAIP3;NEDD4;HDAC1;POLR2J3

    MAP2K7 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K7 itself. We selected most functions MAP2K7 had, and list some proteins which have the same functions with MAP2K7. You can find most of the proteins on our site.

    Function Related Protein
    MAP kinase kinase activityMAP3K9;MAP2K1;PAK3;MAP2K7;MAP2K2;LRRK2;MAP2K6;MAP2K3;MAP3K20
    magnesium ion bindingEPHX2;NUAK2;STK38L;FARSB;ERN2;PTENA;NEK6;LHPP;ITPK1
    protein bindingDNMT3A;SLC30A2;MBIP;GATA1A;NT5C3B;TBX3;CASP2;PGLS;RBMS1
    protein kinase bindingIBTK;CDKN2A;TNNI3;TUBB3;ERRFI1;RACGAP1;CCNY;PIH1D1;VRK2
    protein phosphatase bindingCDH2;PARD3;GRB2;PPP6R1;PIK3R2;JAK3;TRP53;JUPA;KAT2A
    protein serine/threonine kinase activityALPK1;IRAK2;VRK1;MYO3A;MAPK14A;ACVR2B;MAP4K5;WNK1;SYK
    protein tyrosine kinase activityTYK2;MET;JAK2;EPHB4A;FER;KIAA1804;HCK;IGF1RA;EPHA4A

    MAP2K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K7.

    MAP3K7; (dtp3)-tyr,arg,phe; GADD45B; MAPK8IP1

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
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