MAP2K7

  • Official Full Name

    MAP2K7 mitogen-activated protein kinase kinase 7

  • Overview

    The stress response of mammalian cells results in activation of kinases of the SAPK1 and SAPK2 families. The SAP kinases are specifically activated by dual phosphorylation of a conserved T-X-Y motif by MAP kinase kinases (MKK). The 3 isoforms of the SAPK1 family (SAPK1 alpha/jnk2; SAPK1 beta/jnk3; SAPK1 beta/jnk1) are synergistically activated by phosphorylation of the threonine residue by MKK7 and the tyrosine residue by MKK4.
  • Synonyms

    MAP2K7; mitogen-activated protein kinase kinase 7; PRKMK7; dual specificity mitogen-activated protein kinase kinase 7; Jnkk2; MKK7; MEK 7; JNKK 2; MAPKK 7; SAPK kinase 4; MAPK/ERK kinase 7; MAP kinase kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4; MAPKK7; SAPKK4; SAPKK-4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP2K7-8083H Recombinant Human MAP2K7 protein, His & T7-tagged E.coli His/T7
Human MAP2K7-4508HCL Recombinant Human MAP2K7 293 Cell Lysate HEK293 N/A
Human MAP2K7-1511HFL Recombinant Full Length Human MAP2K7 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP2K7-8085H Recombinant Human MAP2K7 Protein, GST-tagged Insect cell GST
Human MAP2K7-1356H Recombinant Human MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP2K7-0394H Recombinant Human MAP2K7 Protein (A2-R419), Tag Free Insect Cell No tag
Human MAP2K7-1356H-B Recombinant Human MAP2K7 Protein Pre-coupled Magnetic Beads HEK293
Human MAP2K7-2337HF Active Recombinant Full Length Human MAP2K7 Protein, GST-tagged Insect (sf21) GST
Human MAP2K7-5009H Recombinant Human MAP2K7 Protein (Thr103-Arg419), N-His tagged E.coli N-His
Human MAP2K7-4603HF Active Recombinant Full Length Human MAP2K7 Protein, GST-tagged Insect (sf21) GST
Human MAP2K7-3775HF Active Recombinant Full Length Human MAP2K7 Protein, GST-tagged E.coli GST
Human MAP2K7-0395H Recombinant Human MAP2K7 Protein (A2-R419), His/GST tagged Insect Cell His/GST
Mouse Map2k7-8084M Recombinant Mouse Map2k7 protein, His & T7-tagged E.coli His/T7
Mouse MAP2K7-9504M Recombinant Mouse MAP2K7 Protein Mammalian Cell His
Mouse MAP2K7-5327M Recombinant Mouse MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Map2k7-3925M Recombinant Mouse Map2k7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MAP2K7-5327M-B Recombinant Mouse MAP2K7 Protein Pre-coupled Magnetic Beads HEK293
Rat MAP2K7-3562R Recombinant Rat MAP2K7 Protein Mammalian Cell His
Rat MAP2K7-3218R Recombinant Rat MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAP2K7-3218R-B Recombinant Rat MAP2K7 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAP2K7-7761Z Recombinant Zebrafish MAP2K7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MAP2K7 Related Articles

MAP2K7 involved in several pathways and played different roles in them. We selected most pathways MAP2K7 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayIKBKG;FGF13A;ARR3A;RAC1;HSPA1A;STMN1B;PRKACBB;TGFBR2;PAK2A
ErbB signaling pathwayPAK2B;BRAF;PRKCBB;PAK1;PRKCB;ERBB4A;ERBB4;EREG;NRG2
Protein processing in endoplasmic reticulumSEC61G;PKZ;CUL1;MBTPS2;SEC61A1;DNAJA1;CAPN2A;RRBP1B;DERL1
Osteoclast differentiationPPP3CA;MAP2K6;SIRP-BETA;FOSL2;IFNGR2;IFNGR1;PPP3R1;FCGR2C;NFKBIA
Toll-like receptor signaling pathwayPIK3CD;TLR4BB;IL8L2;IL-8;AKT2;IL12BA;IL6;IL12A;MYD88
T cell receptor signaling pathwayNFKBIA;PIK3CB;CD28;PIK3R1;CD3G;PPP3CC;SOS1;GRAPA;VAV1
Fc epsilon RI signaling pathwayVAV1;MAPK10;PIK3CA;RAC1;VAV3;PLA2G4A;SYK;IL5;LCP2
TNF signaling pathwayLTA;IKBKG;DNM1L;MAPK10;TRAF3;CCL2;MAPK8;IL6;SELE
Neurotrophin signaling pathwayCAMK2B;PIK3R3;CALML3;SHC1;RPS6KA2;RPS6KA1;MAP2K5;RAP1A;CDC42
GnRH signaling pathwayPRKACG;MAP2K2;GRB2B;MAPK12;PRKCDA;ATF4B1;CAMK2D1;ADCY2B;CALML5
Influenza AIFNGR2;CCL2;KPNA2;NFKBIA;IFNA13;BLB1;IFNB;HSPA8;TNFSF10
Epstein-Barr virus infectionPSMD13;TRAF1;PIK3R5;POLR3K;POLR2A;PSMC2;HLA-A;GTF2E1;PIK3R3

MAP2K7 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K7 itself. We selected most functions MAP2K7 had, and list some proteins which have the same functions with MAP2K7. You can find most of the proteins on our site.

Function Related Protein
ATP bindingVRK2;DCLK3;SPG7;KIF15;DHX38;CERK;TUT1;ULK4;WNK2
MAP kinase kinase activityMAP2K2A;MAP2K2;MAP2K3;MAP2K1;LRRK2;MAP2K7;ALPK2;MAPK14;MAP3K14
enzyme bindingUGT1A4;RARA;PARK2;BLZF1;RXRA;PHKG1;HDAC6;PARK7;EHHADH
magnesium ion bindingSIK2;DXO;FEN1;IDH3A;NIM1;PPM1AB;NT5C1AA;Atp8a2;ALPP
protein bindingDYRK4;RAB1;LCMT1;CLSTN1;WDR34;ZSCAN21;KCNMB4;SIRPB1;LAMP2
protein kinase bindingACVRL1;CCNA2;KCNQ3;FZD5;STX1B;TRIM6;PEBP1;ERRFI1;BCAR1
protein phosphatase bindingMVP;ERBB2;IRS2;DLG3;CDC27;EIF2AK3;DLG4;GRB2;FLT4
protein serine/threonine kinase activityNEK1;SMG1;TTBK1;STK30;NEK6;TAOK3;ACVR2A;MAP4K2;AKT2
protein tyrosine kinase activityBCR;HCK;ERBB2;SRC;MUSK;FYNA;TTN;BAZ1B;JAK1

MAP2K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K7.

MAP3K7; (dtp3)-tyr,arg,phe; GADD45B; MAPK8IP1

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
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