MAP2K7

  • Official Full Name

    MAP2K7 mitogen-activated protein kinase kinase 7

  • Overview

    The stress response of mammalian cells results in activation of kinases of the SAPK1 and SAPK2 families. The SAP kinases are specifically activated by dual phosphorylation of a conserved T-X-Y motif by MAP kinase kinases (MKK). The 3 isoforms of the SAPK1 family (SAPK1 alpha/jnk2; SAPK1 beta/jnk3; SAPK1 beta/jnk1) are synergistically activated by phosphorylation of the threonine residue by MKK7 and the tyrosine residue by MKK4.
  • Synonyms

    MAP2K7; mitogen-activated protein kinase kinase 7; PRKMK7; dual specificity mitogen-activated protein kinase kinase 7; Jnkk2; MKK7; MEK 7; JNKK 2; MAPKK 7; SAPK kinase 4; MAPK/ERK kinase 7; MAP kinase kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4; MAPKK7; SAPKK4; SAPKK-4;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect (sf21)
  • Insect cell
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • Myc
  • DDK
  • N/A
  • N
  • No tag
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MAP2K7-8083H Recombinant Human MAP2K7 protein, His & T7-tagged E.coli His/T7 Tyr113~Val388 (Accession # O14733)
Human MAP2K7-4508HCL Recombinant Human MAP2K7 293 Cell Lysate HEK293 N/A
Human MAP2K7-1511HFL Recombinant Full Length Human MAP2K7 Protein, C-Flag-tagged Mammalian cells Flag
Human MAP2K7-8085H Recombinant Human MAP2K7 Protein, GST-tagged Insect cell GST
Human MAP2K7-1356H Recombinant Human MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MAP2K7-0394H Recombinant Human MAP2K7 Protein (A2-R419), Tag Free Insect Cell No tag A2-R419
Human MAP2K7-1356H-B Recombinant Human MAP2K7 Protein Pre-coupled Magnetic Beads HEK293
Human MAP2K7-2337HF Active Recombinant Full Length Human MAP2K7 Protein, GST-tagged Insect (sf21) GST 1-419(end)
Human MAP2K7-5009H Recombinant Human MAP2K7 Protein (Thr103-Arg419), N-His tagged E.coli N-His Thr103-Arg419
Human MAP2K7-4603HF Active Recombinant Full Length Human MAP2K7 Protein, GST-tagged Insect (sf21) GST 1-419(end)
Human MAP2K7-3775HF Active Recombinant Full Length Human MAP2K7 Protein, GST-tagged E.coli GST 1-419(end)
Human MAP2K7-0395H Recombinant Human MAP2K7 Protein (A2-R419), His/GST tagged Insect Cell His/GST A2-R419
Mouse Map2k7-8084M Recombinant Mouse Map2k7 protein, His & T7-tagged E.coli His/T7 Met181~His429 (Accession # Q8CE90)
Mouse MAP2K7-9504M Recombinant Mouse MAP2K7 Protein Mammalian Cell His
Mouse MAP2K7-5327M Recombinant Mouse MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Map2k7-3925M Recombinant Mouse Map2k7 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse MAP2K7-5327M-B Recombinant Mouse MAP2K7 Protein Pre-coupled Magnetic Beads HEK293
Rat MAP2K7-3562R Recombinant Rat MAP2K7 Protein Mammalian Cell His
Rat MAP2K7-3218R Recombinant Rat MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MAP2K7-3218R-B Recombinant Rat MAP2K7 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish MAP2K7-7761Z Recombinant Zebrafish MAP2K7 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MAP2K7 involved in several pathways and played different roles in them. We selected most pathways MAP2K7 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayPLA2G4C;HSPA1B;PAK2A;CASP3A;PRKCB;FGF1B;PDGFA;LAMTOR3;PPM1BB
ErbB signaling pathwayRAF1A;MTOR;PAK2A;AREGB;ERBB2;AKT1;MAPK10;EREG;MAPK3
Protein processing in endoplasmic reticulumATF4B1;RAD23AA;TRAM1;MAPK8A;UBE2E2;DNAJA2;HSP70;MAN1A;HSP90AA1
Osteoclast differentiationLILRB1;SIRPA;IL1R1;CSF1;FOSB;NCF2;STAT2;TGFB2;TGFBR1
Toll-like receptor signaling pathwayTLR9;IFNA5;IFNA21;CCL3;MAP2K1;IRAK4;NFKBIAA;RAC1;CRFB2
T cell receptor signaling pathwayPTPRC;GRB2;MAPK13;VAV3;CD4;CBLB;PPP3R1;NFATC3;IKBKG
Fc epsilon RI signaling pathwayHRAS;MAPK1;VAV3;FCER1G;RAC3;PLCG1;MAPK13;MAPK10;GAB2
TNF signaling pathwayCXCL1;CASP7;MAP3K5;IKBKG;TNF;VEGFC;Casp3;PIK3R5;MAP3K7
Neurotrophin signaling pathwayRAPGEF1;SOS1;FASLG;IRS1;MAP2K2;MAPK10;YWHAE;RPS6KA6;IRAK2
GnRH signaling pathwayMMP14A;GNRHR4;CALM3B;HRAS;Adcy4;PRKACAB;RAF1B;PTK2B;CALM
Influenza AHSPA1A;PRKCB;IFNA5;IFIH1;IFNA7;IL1B;NXF2;HSPA8;IL6
Epstein-Barr virus infectionCR2;EIF2AK2;TRAF5;PSMD6;CD44;PSMC3;XPO1;TRAF3;HSPA8

MAP2K7 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K7 itself. We selected most functions MAP2K7 had, and list some proteins which have the same functions with MAP2K7. You can find most of the proteins on our site.

Function Related Protein
ATP bindingNADK;HSPA4A;MYH8;PRKAG3;DGKE;CAMK2D2;CLK2;HK1;SMC2
MAP kinase kinase activitySBK3;MAP2K6;MAP3K20;MAP3K9;PAK3;MAP3K14;MAPK10;MAPK14;MAP2K7
enzyme bindingPRKCA;TRIO;HINFP;CCDC99;GOT2;P4HB;UGT1A6A;RPS19BP1;HNRNPUL1
magnesium ion bindingCDC42BPG;NUDT16;SPHK1;ITPK1A;RPS6KA4;TDP2B;STK38;NIM1K;CIB4
protein bindingMEP1B;MDFI;SPSB4;STAP2;UNC45B;SOX7;WIBG;STX16;TXN
protein kinase bindingSPDYA;JTB;THY1;PRDX3;STAT3;CNPPD1;PFKFB2;NME2;MVP
protein phosphatase bindingCSF1R;TP53;SKAP1;DRD1A;ANAPC7;CTNNB1;MAP2K7;LCK;CDH5
protein serine/threonine kinase activityVRK2;BMPR1AA;VRK3;FAM20C;NEK12;WNK1;CHEK1;CDK14;MELK
protein tyrosine kinase activityAatk;AXL;MAP2K5;FGFR1B;INSR;EGFR;INSRB;PTK7A;TTN

MAP2K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K7.

MAP3K7; (dtp3)-tyr,arg,phe; GADD45B; MAPK8IP1

Research Area

Related articles

Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).
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