MAP2K7 Protein


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Official Full Name MAP2K7 mitogen-activated protein kinase kinase 7
Background The stress response of mammalian cells results in activation of kinases of the SAPK1 and SAPK2 families. The SAP kinases are specifically activated by dual phosphorylation of a conserved T-X-Y motif by MAP kinase kinases (MKK). The 3 isoforms of the SAPK1 family (SAPK1 alpha/jnk2; SAPK1 beta/jnk3; SAPK1 beta/jnk1) are synergistically activated by phosphorylation of the threonine residue by MKK7 and the tyrosine residue by MKK4.
Synonyms MAP2K7; mitogen-activated protein kinase kinase 7; PRKMK7; dual specificity mitogen-activated protein kinase kinase 7; Jnkk2; MKK7; MEK 7; JNKK 2; MAPKK 7; SAPK kinase 4; MAPK/ERK kinase 7; MAP kinase kinase 7; JNK-activating kinase 2; c-Jun N-terminal kinase kinase 2; stress-activated protein kinase kinase 4; MAPKK7; SAPKK4; SAPKK-4;
    • Species :
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect (sf21)
    • Insect cell
    • Mammalian Cell
    • Mammalian cells
    • Tag :
    • Flag
    • GST
    • His
    • His (Fc)-Avi
    • His/GST
    • T7
    • Myc/DDK
    • N/A
    • No tag
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MAP2K7-8083H Recombinant Human MAP2K7 protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse Map2k7-8084M Recombinant Mouse Map2k7 protein, His & T7-tagged E.coli His/T7 Inquiry
    Mouse MAP2K7-9504M Recombinant Mouse MAP2K7 Protein Mammalian Cell His Inquiry
    Rat MAP2K7-3562R Recombinant Rat MAP2K7 Protein Mammalian Cell His Inquiry
    Zebrafish MAP2K7-7761Z Recombinant Zebrafish MAP2K7 Mammalian Cell His Inquiry
    Human MAP2K7-4508HCL Recombinant Human MAP2K7 293 Cell Lysate HEK293 N/A Inquiry
    Human MAP2K7-0394H Recombinant Human MAP2K7 Protein (A2-R419), Tag Free Insect Cell No tag Inquiry
    Human MAP2K7-0395H Recombinant Human MAP2K7 Protein (A2-R419), His/GST tagged Insect Cell His/GST Inquiry
    Human MAP2K7-1356H Recombinant Human MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human MAP2K7-1511HFL Recombinant Full Length Human MAP2K7 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Human MAP2K7-2337HF Recombinant Full Length Human MAP2K7 Protein, GST-tagged Insect (sf21) GST Inquiry
    Rat MAP2K7-3218R Recombinant Rat MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human MAP2K7-3775HF Recombinant Full Length Human MAP2K7 Protein, GST-tagged E.coli GST Inquiry
    Human MAP2K7-4603HF Recombinant Full Length Human MAP2K7 Protein, GST-tagged Insect (sf21) GST Inquiry
    Mouse MAP2K7-5327M Recombinant Mouse MAP2K7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi Inquiry
    Human MAP2K7-8085H Recombinant Human MAP2K7 Protein, GST-tagged Insect cell GST Inquiry
    Mouse Map2k7-3925M Recombinant Mouse Map2k7 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry

    MAP2K7 involved in several pathways and played different roles in them. We selected most pathways MAP2K7 participated on our site, such as MAPK signaling pathway, ErbB signaling pathway, Protein processing in endoplasmic reticulum, which may be useful for your reference. Also, other proteins which involved in the same pathway with MAP2K7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    MAPK signaling pathway MAP3K2; MAP3K13; CACNB1; NFKB2; MAP3K4; PLA2G4AA; NTF4; HSPB1; Casp3; MAPT
    ErbB signaling pathway PAK3; AREG; CDKN1BA; ERBB3A; ERBB3B; AKT2L; NRG2B; ERBB4; PIK3CA; MAPK8B
    Protein processing in endoplasmic reticulum MAPK9; SEC31B; RNF5; MBTPS1; DNAJB12; LMAN1L; HSP70L; ERO1L; HSPA4L; PDIP5
    Osteoclast differentiation TAB2; PPARG; LILRA4; LILRB2; STAT2; NFKBIA; CALCR; MAP2K1; PPP3R2; TRAF6
    Toll-like receptor signaling pathway IL8L1; MAPK8; RIPK1L; TRAF6; MAPK11; TLR1LA; CD86; CXCL8B.3; CASP8; CD14
    T cell receptor signaling pathway IKBKG; IKBKB; HRAS; PDCD1; PAK7; AKT1; MAPK3; PRKCQ; AKT2; CABIN1
    Fc epsilon RI signaling pathway PLA2G4C; SOS1; VAV3; RAC1; PLA2G4A; PDPK1; IL3; IL5; KRAS; GAB2
    TNF signaling pathway MAGI2; ITCH; MAPK10; TRAF1; DNM1L; TRADD; FADD; LIF; IL6; CXCL3
    Neurotrophin signaling pathway IRS1; MAPK8; MAP2K7; MAGED1; PIK3R3; ABL1; BDNF; RAP1B; NTF4; NFKBIB
    GnRH signaling pathway GRB2; CALM2A; HRASB; ATF4; CAMK2G1; PRKACAA; PLA2G4D; GNA11A; MAP2K4; PTK2BB
    Epstein-Barr virus infection NFKBIA; HLA-DRB1; XPO1; HSPA2; PSMD4; EIF2AK1; HLA-A; PSMD1; ENTPD1; YWHAH

    MAP2K7 has several biochemical functions, for example, ATP binding, MAP kinase kinase activity, enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MAP2K7 itself. We selected most functions MAP2K7 had, and list some proteins which have the same functions with MAP2K7. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding VWA8; OAS2; MYH6; SIK2; RIPK1; KIF15; DDX23; EPHB3; DDX10; OPLAH
    MAP kinase kinase activity PAK3; MAP2K2; MAPK10; MAP2K1; MAP3K14; MAP3K9; MAP2K6; LRRK2; MAPK14; MAP2K2A
    enzyme binding RPS3; RYR2; GRIN1; CAD; KALRN; HDAC3; TSPYL1; CUTA; PEBP1; NPC2
    magnesium ion binding RPS6KA2; FAN1; STK38L; PPM1AA; ENO3; IDH3A; ATP8B1; PKM2; NIM1K; HMGCL
    protein binding PAGE5; MPPE1; HIPK2; MRPS23; ZNF821; KCP; DTL; CDC5L; TSEN2; HIPK1
    protein kinase binding NGFRAP1; CDC25A; DPYSL2; GHR; NME2; PRKAG3; DOK7; PLK1; LIPE; MAP2K7
    protein phosphatase binding HSF4; SNX3; JUPA; IRS2; RPA2; RPA3; PPP1R3C; Itga10&Itgb1; SHOC2; KAT2A
    protein serine/threonine kinase activity PRKAA2; EIF2AK4; STK32C; ADCK2; ULK1A; PIM1; LRRK2; TRIO; CAMK2G1; PRKD1
    protein tyrosine kinase activity TEK; EPHB4A; FYNA; ERBB4; EPHB2; WEE1; EPHA2A; PTK2; JAK2B; ABL2

    MAP2K7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MAP2K7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MAP2K7.

    MAP3K7; (dtp3)-tyr,arg,phe; GADD45B; MAPK8IP1

    Aslani, F; Schuppe, HC; et al. Targeting high mobility group box protein 1 ameliorates testicular inflammation in experimental autoimmune orchitis. HUMAN REPRODUCTION 30:417-431(2015).
    Chang, CH; Wang, Y; et al. Extensive crosslinking of CD22 by epratuzumab triggers BCR signaling and caspase-dependent apoptosis in human lymphoma cells. MABS 7:199-211(2015).

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