MARK2

  • Official Full Name

    MAP/microtubule affinity-regulating kinase 2

  • Overview

    Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family (

  • Synonyms

    MARK2;MAP/microtubule affinity-regulating kinase 2;ELKL motif kinase , EMK1;serine/threonine-protein kinase MARK2;ELKL motif kinase 1;PAR 1;Par1b;protein serine/threonine kinase;Ser/Thr protein kinase PAR 1B;serine/threonine kinase;PAR1 homolog

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Sf21 Cells
  • His
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    MARK2 involved in several pathways and played different roles in them. We selected most pathways MARK2 participated on our site, such as LKB1 signaling events,Notch signaling pathway,Regulation of Microtubule Cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    TNF-alpha/NF-kB Signaling Pathway TRPC4AP,COPS3,PFDN2,LRPPRC,USP2,G3BP2,UNC5CL,PPP1R13L,TANK,ZFAND5
    LKB1 signaling events MARK4,MAP2,CTSD,SIK3,STK11IP,CDC37
    Regulation of Microtubule Cytoskeleton TESK2,MARK1,TPPP,CFL2,MAP1B,DPYSL2
    Notch signaling pathway MIB1,HER6,NOTCH1,DTX3L,ADAM17A,MYCBP,DTX2,RBPJA,LFNG,MFAP2
    Wnt Signaling Pathway NetPath BCL9,HIPK2,ANKRD6,TCF4,SALL1,PAX2,BRD7,MAP1B,ROR2,CSNK2A1P

    Protein Function

    MARK2 has several biochemical functions, for example, ATP binding,lipid binding,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARK2 itself. We selected most functions MARK2 had, and list some proteins which have the same functions with MARK2. You can find most of the proteins on our site.

    Function Related Protein
    tau-protein kinase activity CDK5,MARK4,PHKG2,GSK3B,MARK1,GSK3A,PRKAA1,PHKG1,CSNK1D
    ATP binding ORC1L,SMCHD1,NMNAT3,CKMT2A,TOR1,CSNK1G3,CLCN4-2,PPP1CA,ATP1A1,HARS2
    lipid binding CRABP2A,FABP1B.1,PLTP,ACBD7,ACBD4,BAIAP2L2B,ANXA6,LPAR4,ATP5G1,FNBP1
    protein kinase activator activity FAM58A,NKX3-1,GPRC5B,EPO,DBF4B,MAPK8IP2,WNT11,PRKAG2,CAB39,PIK3CA
    protein serine/threonine kinase activity LMTK2,LIMK1,RPS6KAL,TRIO,MASTL,CAMKK1A,BSK146,ULK4,PIM1,MTOR
    magnesium ion binding ENO3,MTPAP,NT5C1BA,ZNF143B,ALPI,GTPBP5,HPRT1,DOM3Z,STK11,IDH2
    protein binding RAB37,KCNQ5,AHCY,GAS2L3,STARD13,GFI1,TESK1,MID2,PLK2,TMEM106C
    poly(A) RNA binding CSTF2T,AKAP17A,POLR2A,PRPF40A,NAT10,ELAVL2,EPPK1,SRSF12,EWSR1,MYEF2

    Interacting Protein

    MARK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARK2.

    YWHAH;YWHAZ;MTCL1;MAPT

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