MARK2

  • Official Full Name

    MAP/microtubule affinity-regulating kinase 2

  • Overview

    Microtubule associated proteins regulate the stability of microtubules and control processes such as cell polarity/differentiation, neurite outgrowth, cell division and organelle trafficking. The MARK (MAP/microtubule affinity-regulating kinases) family (

  • Synonyms

    MARK2;MAP/microtubule affinity-regulating kinase 2;ELKL motif kinase , EMK1;serine/threonine-protein kinase MARK2;ELKL motif kinase 1;PAR 1;Par1b;protein serine/threonine kinase;Ser/Thr protein kinase PAR 1B;serine/threonine kinase;PAR1 homolog

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • E.coli
  • Sf9 Cells
  • Mammalian Cells
  • HEK293
  • Sf21 Cells
  • His
  • GST
  • Non
  • Avi
  • Fc
  • DDK
  • Myc

    Involved Pathway

    MARK2 involved in several pathways and played different roles in them. We selected most pathways MARK2 participated on our site, such as LKB1 signaling events,Notch signaling pathway,Regulation of Microtubule Cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with MARK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    LKB1 signaling events SIK3,CDC37,MARK4,MAP2,CTSD,STK11IP
    TNF-alpha/NF-kB Signaling Pathway KPNA6,AKAP8,DPF2,RNF25,RNF216,NR2C2,SMARCE1,PPP1R13L,NKIRAS1,COPS3
    Regulation of Microtubule Cytoskeleton TPPP,TESK2,CFL2,MARK1,MAP1B,DPYSL2
    Notch signaling pathway CTBP2,DVL3A,CNTN6,CTBP1,APH1B,DLK1,RBPJ,ADAM17A,NUMBL,MFAP5
    Wnt Signaling Pathway NetPath HIPK2,PAX2,SALL1,TAX1BP3,BRD7,SOX1,ROR2,ANKRD6,BCL9,CRYBB2

    Protein Function

    MARK2 has several biochemical functions, for example, ATP binding,lipid binding,magnesium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MARK2 itself. We selected most functions MARK2 had, and list some proteins which have the same functions with MARK2. You can find most of the proteins on our site.

    Function Related Protein
    tau-protein kinase activity PRKAA1,PHKG1,GSK3B,GSK3A,CSNK1D,MARK1,PHKG2,MARK4,CDK5
    protein serine/threonine kinase activity STK40,CSNK1DA,BMPR1A,CAMK1DA,RPS6KA4,ACVR1B,MINK1,FASTK,PRKCHA,PLK3
    poly(A) RNA binding HDGF,DUT,LARP1,PPAN,P4HB,PRMT1,PSMC1,UPF1,RPS14,RPL7A
    lipid binding BPIFB4,APOL4,ACBD5,Fert2,PACSIN1B,AP2M1,APOA1B,FABP1A,APOA4,SH3GL3
    ATP binding EGFRA,ACACA,MAP3K3,SIK3,MTHFD1L,P2RX4B,PFKL,ATP1A3A,CENPE,CSNK1G2
    protein kinase activator activity TOM1L1,WNT11,AGAP2,FGF13,FAM58A,STK11,PRKAG2,NKX3,MT3,NKX3-1
    protein binding KIR2DL4,BCAP31,XAGE2,SH3BP4,HNRNPR,TNK1,VSIG4,FAM86A,HOXB7,HPCAL4
    magnesium ion binding MAP3K6,NT5C3A,ENO1,NT5C1BA,NEK6,ATP9B,CDC42BPA,RPS6KAL,DYRK3,PRPS1A

    Interacting Protein

    MARK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MARK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MARK2.

    YWHAH;YWHAZ;MTCL1;MAPT

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