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MC1R

  • Official Full Name

    melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

  • Overview

    This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
  • Synonyms

    MC1R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocyte-stimulating hormone receptor; MSH R; MC1-R; Melanocortin 1 receptor; Melanocortin receptor 1; MSH-R; MSHR; MSHR_HUMAN; melanotropin receptor; CMM5; SHEP2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Assay Kits
  • Alces alces alces (European moose) (Elk)
  • Allenopithecus nigroviridis (Allen's swamp monkey)
  • Alouatta caraya (Black howler monkey)
  • Alouatta palliata (Mantled howler monkey)
  • Alouatta pigra (Guatemalan howler monkey) (Mexican black howler monkey)
  • Alouatta sara (Bolivian red howler monkey)
  • Alouatta seniculus (Red howler monkey)
  • Ateles paniscus (Black spider monkey) (Red-faced black spider monkey)
  • Bos taurus (Bovine)
  • Callimico goeldii (Goeldi's marmoset)
  • Callithrix argentata (Silvery marmoset) (Mico argentatus)
  • Callithrix geoffroyi (Geoffroy's marmoset)
  • Callithrix jacchus (White-tufted-ear marmoset)
  • Callithrix pygmaea (Pygmy marmoset) (Cebuella pygmaea)
  • Canis lupus familiaris (Dog) (Canis familiaris)
  • Capreolus capreolus (Roe deer)
  • Cebus albifrons (White-fronted capuchin)
  • Cercopithecus diana (Diana monkey)
  • Cercopithecus mitis (Blue monkey)
  • Cercopithecus neglectus (De Brazza's monkey)
  • Cervus elaphus (Red deer)
  • Chaetodipus baileyi (Bailey's pocket mouse) (Perognathus baileyi)
  • Chaetodipus penicillatus (Desert pocket mouse) (Perognathus penicillatus)
  • Chicken
  • Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops)
  • Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey)
  • Dama dama (Fallow deer) (Cervus dama)
  • Equus caballus (Horse)
  • Erythrocebus patas (Red guenon) (Cercopithecus patas)
  • Eulemur fulvus fulvus (Brown lemur)
  • Felis catus (Cat) (Felis silvestris catus)
  • Galago senegalensis (Northern lesser bushbaby) (Senegal bushbaby)
  • Gallus gallus (Chicken)
  • Goat
  • Gorilla gorilla gorilla (Western lowland gorilla)
  • Hapalemur griseus (Gray gentle lemur) (Eastern lesser bamboo lemur)
  • Homo sapiens (Human)
  • Human
  • Hylobates lar (Common gibbon) (White-handed gibbon)
  • Hylobates muelleri (Mueller's Bornean gibbon)
  • Lemur catta (Ring-tailed lemur)
  • Leontopithecus chrysomelas (Golden-headed lion tamarin)
  • Leontopithecus chrysopygus (Golden-rumped lion tamarin) (Leontopithecus rosalia chrysopygus)
  • Leontopithecus rosalia (Golden lion tamarin)
  • Loris tardigradus (Slender loris)
  • Macaca mulatta (Rhesus macaque)
  • Macaca nemestrina (Pig-tailed macaque)
  • Macaca nigra (Celebes black macaque) (Crested black macaque)
  • Macaca silenus (Lion-tailed macaque)
  • Macaca sylvanus (Barbary macaque)
  • Mammuthus primigenius (Siberian woolly mammoth)
  • Mandrillus sphinx (Mandrill) (Papio sphinx)
  • Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin)
  • Mouse
  • Mus musculus (Mouse)
  • Nomascus concolor (Black crested gibbon) (Hylobates concolor)
  • Ovibos moschatus (Muskox)
  • Ovis aries (Sheep)
  • Pan troglodytes (Chimpanzee)
  • Panthera onca (Jaguar) (Felis onca)
  • Papio anubis (Olive baboon)
  • Papio hamadryas (Hamadryas baboon)
  • Pongo pygmaeus (Bornean orangutan)
  • Presbytis comata (Grizzled leaf monkey)
  • Puma yagouaroundi (Jaguarundi) (Herpailurus yagouaroundi)
  • Rangifer tarandus (Reindeer) (Cervus tarandus)
  • Saguinus fuscicollis (Brown-headed tamarin)
  • Saguinus geoffroyi (Geoffroy's tamarin)
  • Saguinus imperator (Emperor tamarin)
  • Saguinus midas (Midas tamarin) (Golden-handed tamarin)
  • Saguinus oedipus (Cotton-top tamarin)
  • Saimiri oerstedii (Central American squirrel monkey)
  • Semnopithecus entellus (Hanuman langur) (Presbytis entellus)
  • Sus scrofa (Pig)
  • Trachypithecus auratus (Javan langur)
  • Trachypithecus cristatus (Silvered leaf-monkey) (Presbytis cristata)
  • Trachypithecus francoisi (Francois' leaf monkey) (Presbytis francoisi)
  • Trachypithecus obscurus (Dusky leaf-monkey) (Presbytis obscura)
  • Varecia variegata rubra (Red ruffed lemur) (Varecia rubra)
  • Varecia variegata variegata (Black and white ruffed lemur)
  • Vulpes lagopus (Arctic fox) (Alopex lagopus)
  • Vulpes vulpes (Red fox)
  • Zebrafish
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • C
  • His
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MC1R-29451TH Recombinant Human MC1R Wheat Germ N/A 100 amino acids
Human MC1R-4434HCL Recombinant Human MC1R 293 Cell Lysate HEK293 N/A
Mouse Mc1r-0183M Recombinant Mouse Mc1r Full Length Transmembrane Protein(1-315aa), His-tagged(VLPs) HEK293 C-His 1-315aa
Alces alces alces (European moose) (Elk) RFL29288AF Recombinant Full Length Alces Alces Alces Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Allenopithecus nigroviridis (Allen's swamp monkey) RFL22448AF Recombinant Full Length Allenopithecus Nigroviridis Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Alouatta caraya (Black howler monkey) RFL6739AF Recombinant Full Length Alouatta Caraya Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Alouatta palliata (Mantled howler monkey) RFL36034AF Recombinant Full Length Alouatta Palliata Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Alouatta pigra (Guatemalan howler monkey) (Mexican black howler monkey) RFL20458AF Recombinant Full Length Alouatta Pigra Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Alouatta sara (Bolivian red howler monkey) RFL4558AF Recombinant Full Length Alouatta Sara Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Alouatta seniculus (Red howler monkey) RFL20641AF Recombinant Full Length Alouatta Seniculus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Ateles paniscus (Black spider monkey) (Red-faced black spider monkey) RFL31716AF Recombinant Full Length Ateles Paniscus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Bos taurus (Bovine) RFL31770BF Recombinant Full Length Bovine Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Callimico goeldii (Goeldi's marmoset) RFL21131CF Recombinant Full Length Callimico Goeldii Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-344)
Callithrix argentata (Silvery marmoset) (Mico argentatus) RFL32738CF Recombinant Full Length Callithrix Argentata Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-344)
Callithrix geoffroyi (Geoffroy's marmoset) RFL1863CF Recombinant Full Length Callithrix Geoffroyi Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-344)
Callithrix jacchus (White-tufted-ear marmoset) RFL30884CF Recombinant Full Length Callithrix Jacchus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-344)
Callithrix pygmaea (Pygmy marmoset) (Cebuella pygmaea) RFL30418CF Recombinant Full Length Cebuella Pygmaea Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-344)
Canis lupus familiaris (Dog) (Canis familiaris) RFL23397CF Recombinant Full Length Dog Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Capreolus capreolus (Roe deer) RFL17811CF Recombinant Full Length Capreolus Capreolus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Cebus albifrons (White-fronted capuchin) RFL32755CF Recombinant Full Length Cebus Albifrons Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-316)
Cercopithecus diana (Diana monkey) RFL3748CF Recombinant Full Length Cercopithecus Diana Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Cercopithecus mitis (Blue monkey) RFL16940CF Recombinant Full Length Cercopithecus Mitis Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Cercopithecus neglectus (De Brazza's monkey) RFL15019CF Recombinant Full Length Cercopithecus Neglectus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Cervus elaphus (Red deer) RFL15327CF Recombinant Full Length Cervus Elaphus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Chaetodipus baileyi (Bailey's pocket mouse) (Perognathus baileyi) RFL20250CF Recombinant Full Length Chaetodipus Baileyi Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Chaetodipus penicillatus (Desert pocket mouse) (Perognathus penicillatus) RFL34928CF Recombinant Full Length Chaetodipus Penicillatus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Chlorocebus aethiops (Green monkey) (Cercopithecus aethiops) RFL36441CF Recombinant Full Length Chlorocebus Aethiops Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Colobus guereza (Mantled guereza) (Eastern black-and-white colobus monkey) RFL2270CF Recombinant Full Length Colobus Guereza Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Dama dama (Fallow deer) (Cervus dama) RFL25732DF Recombinant Full Length Dama Dama Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Equus caballus (Horse) RFL1765EF Recombinant Full Length Horse Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Erythrocebus patas (Red guenon) (Cercopithecus patas) RFL19212EF Recombinant Full Length Erythrocebus Patas Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Eulemur fulvus fulvus (Brown lemur) RFL1229EF Recombinant Full Length Eulemur Fulvus Fulvus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Felis catus (Cat) (Felis silvestris catus) RFL14300FF Recombinant Full Length Cat Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Galago senegalensis (Northern lesser bushbaby) (Senegal bushbaby) RFL3158GF Recombinant Full Length Galago Senegalensis Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Gallus gallus (Chicken) RFL3134GF Recombinant Full Length Chicken Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-314)
Goat RFL24495CF Recombinant Full Length Goat Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Gorilla gorilla gorilla (Western lowland gorilla) RFL5188GF Recombinant Full Length Gorilla Gorilla Gorilla Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-316)
Hapalemur griseus (Gray gentle lemur) (Eastern lesser bamboo lemur) RFL18232HF Recombinant Full Length Hapalemur Griseus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Homo sapiens (Human) RFL19774HF Recombinant Full Length Human Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317aa )
Hylobates lar (Common gibbon) (White-handed gibbon) RFL31045HF Recombinant Full Length Hylobates Lar Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Hylobates muelleri (Mueller's Bornean gibbon) RFL8537HF Recombinant Full Length Hylobates Muelleri Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Lemur catta (Ring-tailed lemur) RFL28065LF Recombinant Full Length Lemur Catta Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Leontopithecus chrysomelas (Golden-headed lion tamarin) RFL17645LF Recombinant Full Length Leontopithecus Chrysomelas Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-310)
Leontopithecus chrysopygus (Golden-rumped lion tamarin) (Leontopithecus rosalia chrysopygus) RFL25188LF Recombinant Full Length Leontopithecus Chrysopygus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-318)
Leontopithecus rosalia (Golden lion tamarin) RFL10130LF Recombinant Full Length Leontopithecus Rosalia Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-318)
Loris tardigradus (Slender loris) RFL23573LF Recombinant Full Length Loris Tardigradus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Macaca mulatta (Rhesus macaque) RFL15814MF Recombinant Full Length Macaca Mulatta Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Macaca nemestrina (Pig-tailed macaque) RFL956MF Recombinant Full Length Macaca Nemestrina Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Macaca nigra (Celebes black macaque) (Crested black macaque) RFL7457MF Recombinant Full Length Macaca Nigra Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Macaca silenus (Lion-tailed macaque) RFL5087MF Recombinant Full Length Macaca Silenus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Macaca sylvanus (Barbary macaque) RFL14475MF Recombinant Full Length Macaca Sylvanus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Mammuthus primigenius (Siberian woolly mammoth) RFL22525MF Recombinant Full Length Mammuthus Primigenius Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Mandrillus sphinx (Mandrill) (Papio sphinx) RFL10558MF Recombinant Full Length Mandrillus Sphinx Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Miopithecus talapoin (Angolan talapoin) (Cercopithecus talapoin) RFL19982MF Recombinant Full Length Miopithecus Talapoin Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Mus musculus (Mouse) RFL5631MF Recombinant Full Length Mouse Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-315)
Nomascus concolor (Black crested gibbon) (Hylobates concolor) RFL34363NF Recombinant Full Length Nomascus Concolor Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Ovibos moschatus (Muskox) RFL30979OF Recombinant Full Length Ovibos Moschatus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Ovis aries (Sheep) RFL16665OF Recombinant Full Length Sheep Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Pan troglodytes (Chimpanzee) RFL18956PF Recombinant Full Length Pan Troglodytes Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Panthera onca (Jaguar) (Felis onca) RFL15670PF Recombinant Full Length Panthera Onca Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Papio anubis (Olive baboon) RFL6831PF Recombinant Full Length Papio Anubis Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Papio hamadryas (Hamadryas baboon) RFL31862PF Recombinant Full Length Papio Hamadryas Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Pongo pygmaeus (Bornean orangutan) RFL16912PF Recombinant Full Length Pongo Pygmaeus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Presbytis comata (Grizzled leaf monkey) RFL23245PF Recombinant Full Length Presbytis Comata Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Puma yagouaroundi (Jaguarundi) (Herpailurus yagouaroundi) RFL16275PF Recombinant Full Length Puma Yagouaroundi Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Rangifer tarandus (Reindeer) (Cervus tarandus) RFL24596RF Recombinant Full Length Rangifer Tarandus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Saguinus fuscicollis (Brown-headed tamarin) RFL16270SF Recombinant Full Length Saguinus Fuscicollis Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-316)
Saguinus geoffroyi (Geoffroy's tamarin) RFL9520SF Recombinant Full Length Saguinus Geoffroyi Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-316)
Saguinus imperator (Emperor tamarin) RFL23282SF Recombinant Full Length Saguinus Imperator Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Saguinus midas (Midas tamarin) (Golden-handed tamarin) RFL36130SF Recombinant Full Length Saguinus Midas Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Saguinus oedipus (Cotton-top tamarin) RFL24833SF Recombinant Full Length Saguinus Oedipus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Saimiri oerstedii (Central American squirrel monkey) RFL36275SF Recombinant Full Length Saimiri Oerstedii Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Semnopithecus entellus (Hanuman langur) (Presbytis entellus) RFL19973SF Recombinant Full Length Semnopithecus Entellus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Sus scrofa (Pig) RFL17659SF Recombinant Full Length Pig Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-320)
Trachypithecus auratus (Javan langur) RFL10997TF Recombinant Full Length Trachypithecus Auratus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Trachypithecus cristatus (Silvered leaf-monkey) (Presbytis cristata) RFL20828TF Recombinant Full Length Trachypithecus Cristatus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Trachypithecus francoisi (Francois' leaf monkey) (Presbytis francoisi) RFL17719TF Recombinant Full Length Trachypithecus Francoisi Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Trachypithecus obscurus (Dusky leaf-monkey) (Presbytis obscura) RFL4535TF Recombinant Full Length Trachypithecus Obscurus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Varecia variegata rubra (Red ruffed lemur) (Varecia rubra) RFL26092VF Recombinant Full Length Varecia Variegata Rubra Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Varecia variegata variegata (Black and white ruffed lemur) RFL27339VF Recombinant Full Length Varecia Variegata Variegata Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Vulpes lagopus (Arctic fox) (Alopex lagopus) RFL29405VF Recombinant Full Length Vulpes Lagopus Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Vulpes vulpes (Red fox) RFL10108VF Recombinant Full Length Vulpes Vulpes Melanocyte-Stimulating Hormone Receptor(Mc1R) Protein, His-Tagged E.coli expression system His Full Length (1-317)
Zebrafish MC1R-9612Z Recombinant Zebrafish MC1R Mammalian Cell His
Chicken MC1R-3109C Recombinant Chicken MC1R Mammalian Cell His
Kit-1008 Cell Migration/Chemotaxis Assay Kit (96-well, 3 μm) N/A
Kit-1371 MC1R U2OS β-Arrestin GPCR Assay Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MC1R Related Articles
  • MC1R Related Gene Family

MC1R involved in several pathways and played different roles in them. We selected most pathways MC1R participated on our site, such as Neuroactive ligand-receptor interaction, Melanogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with MC1R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Neuroactive ligand-receptor interactionPRSS3;HTR5AL;MTNR1BB;TRPV1;HTR1D;TAAR14F;GH2;TAAR12E;F2RL2
MelanogenesisWNT5A;KRAS;PRKCB;GNAS;KITLGB;ADCY1A;MC1R;FZD3;FZD3A

MC1R has several biochemical functions, for example, G-protein coupled peptide receptor activity, hormone binding, melanocortin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MC1R itself. We selected most functions MC1R had, and list some proteins which have the same functions with MC1R. You can find most of the proteins on our site.

Function Related Protein
G-protein coupled peptide receptor activityGPR84;NPR3;TSHR;MCHR2;GPR37;LHCGR;RXFP4;GPR37L1;FSHR
hormone bindingGPR30;UCN2;ADIPOR2;MC5R;NPR1;NPR3;ADIPOR1B;TTR;AMHR2
melanocortin receptor activityMC5RB;MC5R;MC5RA;MC2R;MC1R;MC3R;MC4R
melanocyte-stimulating hormone receptor activityMC3R;MC1R;MC4R
protein bindingCALB1;HDDC2;SEC13;KRR1;FES;PDGFRB;GALT;CCDC87;STBD1
ubiquitin protein ligase bindingRANGAP1;MFN2;UBE2K;RPA2;SMAD5;CUL4A;UBE2S;SLC25A5;RAD18

MC1R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MC1R here. Most of them are supplied by our site. Hope this information will be useful for your research of MC1R.

MRAP; MRAP2

Duarte, CW; Stohn, JP; et al. Elevated Plasma Levels of the Pituitary Hormone Cthrc1 in Individuals with Red Hair but Not in Patients with Solid Tumors. PLOS ONE 9:-(2014).
Spichty, R; Balimann, M; et al. A bioassay for the detection of neutralizing antibodies against the alpha-melanocyte stimulating hormone analog afamelanotide in patients with erythropoietic protoporphyria. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 75:192-198(2013).
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