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Official Full Name melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
Background This intronless gene encodes the receptor protein for melanocyte-stimulating hormone (MSH). The encoded protein, a seven pass transmembrane G protein coupled receptor, controls melanogenesis. Two types of melanin exist: red pheomelanin and black eumelanin. Gene mutations that lead to a loss in function are associated with increased pheomelanin production, which leads to lighter skin and hair color. Eumelanin is photoprotective but pheomelanin may contribute to UV-induced skin damage by generating free radicals upon UV radiation. Binding of MSH to its receptor activates the receptor and stimulates eumelanin synthesis. This receptor is a major determining factor in sun sensitivity and is a genetic risk factor for melanoma and non-melanoma skin cancer. Over 30 variant alleles have been identified which correlate with skin and hair color, providing evidence that this gene is an important component in determining normal human pigment variation.
Synonyms MC1R; melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor); melanocyte-stimulating hormone receptor; MSH R; MC1-R; Melanocortin 1 receptor; Melanocortin receptor 1; MSH-R; MSHR; MSHR_HUMAN; melanotropin receptor; CMM5; SHEP2
    • Species :
    • Chicken
    • Human
    • Zebrafish
    • Source :
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MC1R-29451TH Recombinant Human MC1R Wheat Germ N/A
    Human MC1R-4434HCL Recombinant Human MC1R 293 Cell Lysate HEK293 N/A
    Chicken MC1R-3109C Recombinant Chicken MC1R Mammalian Cell His
    Zebrafish MC1R-9612Z Recombinant Zebrafish MC1R Mammalian Cell His
    Kit-1008 Cell Migration/Chemotaxis Assay Kit (96-well, 3 μm) N/A
    Kit-1371 MC1R U2OS β-Arrestin GPCR Assay Kit N/A

    mc1r involved in several pathways and played different roles in them. We selected most pathways mc1r participated on our site, such as Neuroactive ligand-receptor interaction, Melanogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with mc1r were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Neuroactive ligand-receptor interaction TACR1; GLRA2; LOC100328615; TAAR7A; S1PR2; GABRB2; TAAR9; PTGER2B; TAAR10A; ADRA2DB
    Melanogenesis PLCB3; WNT11B; NRAS; a; Adcy4; CAMK2A; GNAI2A; MC1R; WNT8A; GNAO1

    mc1r has several biochemical functions, for example, G-protein coupled peptide receptor activity, hormone binding, melanocortin receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by mc1r itself. We selected most functions mc1r had, and list some proteins which have the same functions with mc1r. You can find most of the proteins on our site.

    Function Related Protein
    G-protein coupled peptide receptor activity CYSLTR2; FSHR; NPR1; GPR37; GRPR; LTB4R; TSHR; NPR3; GPR37L1; MC1R
    hormone binding LRP2; NPR1; ADIPOR1A; NPR2; MC5R; UCN2; NPR3; TTR; AMHR2; GPR30
    melanocortin receptor activity MC3R; MC5RB; MC5R; MC1R; MC4R; MC2R; MC5RA
    melanocyte-stimulating hormone receptor activity MC3R; MC4R; MC1R
    protein binding NDP; CD226; C8orf4; ZBTB33; GSTK1; C1orf35; GZMM; USP14; CSRNP2; TTC25
    ubiquitin protein ligase binding PA2G4; ATXN3; UBE2H; ARRB1; H2-AB1; TRIOBP; CDC34; UBE2Z; UBXN6; CBS

    mc1r has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mc1r here. Most of them are supplied by our site. Hope this information will be useful for your research of mc1r.


    Duarte, CW; Stohn, JP; et al. Elevated Plasma Levels of the Pituitary Hormone Cthrc1 in Individuals with Red Hair but Not in Patients with Solid Tumors. PLOS ONE 9:-(2014).
    Spichty, R; Balimann, M; et al. A bioassay for the detection of neutralizing antibodies against the alpha-melanocyte stimulating hormone analog afamelanotide in patients with erythropoietic protoporphyria. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS 75:192-198(2013).

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