MCFD2

Official Full Name

multiple coagulation factor deficiency 2
Overview

This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 (lectin mannose binding protein 1; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D); a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3 UTR of this gene contains a transposon-like human repeat element named THE 1. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms

MCFD2; multiple coagulation factor deficiency 2; multiple coagulation factor deficiency protein 2; F5F8D; LMAN1IP; SDNSF; neural stem cell derived neuronal survival protein; neural stem cell-derived neuronal survival protein; F5F8D2; DKFZp686G21263;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat
Zebrafish

Source

E. coli
E.coli
HEK293
HEK293T
Mammalian Cell

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MCFD2-28037TH	Recombinant Human MCFD2, T7 -tagged	E.coli	T7	120 amino acids	Inquiry
Human	MCFD2-29454TH	Recombinant Human MCFD2, T7 -tagged	E.coli	T7		Inquiry
Human	MCFD2-1836H	Recombinant Human MCFD2, T7-tagged	E.coli	T7		Inquiry
Human	MCFD2-4425HCL	Recombinant Human MCFD2 293 Cell Lysate	HEK293	Non		Inquiry
Human	MCFD2-4405H	Recombinant Human MCFD2 Protein, Myc/DDK-tagged, C13 and N15-labeled	HEK293T	Myc&DDK		Inquiry
Human	MCFD2-12H	Recombinant Human MCFD2 protein, His-tagged	E. coli	N-His	1-146 aa	Inquiry
Human	MCFD2-13H	Recombinant Human MCFD2 Protein, His-tagged	E. coli	C-His	Glu27-Gln146	$319 / 50ug
Human	MCFD2-14H	Recombinant Human MCFD2 protein, His-tagged	HEK293	C-His	Glu27-Gln146	Inquiry
Mouse	Mcfd2-3994M	Recombinant Mouse Mcfd2 Protein, Myc/DDK-tagged	HEK293T	Myc&DDK		Inquiry
Rat	MCFD2-3616R	Recombinant Rat MCFD2 Protein	Mammalian Cell	His		Inquiry
Rat	MCFD2-3272R	Recombinant Rat MCFD2 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Rat	MCFD2-3272R-B	Recombinant Rat MCFD2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Zebrafish	MCFD2-1473Z	Recombinant Zebrafish MCFD2	Mammalian Cell	His		Inquiry
Chicken	MCFD2-1542C	Recombinant Chicken MCFD2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

MCFD2 involved in several pathways and played different roles in them. We selected most pathways MCFD2 participated on our site, such as Asparagine N-linked glycosylation, COPII (Coat Protein 2) Mediated Vesicle Transport, Cargo concentration in the ER, which may be useful for your reference. Also, other proteins which involved in the same pathway with MCFD2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Asparagine N-linked glycosylation	NAPAB;DERL2;NEU3;BET1;ANKRD28;SERPINA1L;SCFD1;SEC23IP;NAPAA
COPII (Coat Protein 2) Mediated Vesicle Transport	PPP6R3;NSFB;GORASP1;ANKRD28;CNIH3;TRAPPC3;TRAPPC6BL;TMED10;SEC22C
Cargo concentration in the ER	SEC24A;AREG;CTSZ;MIA3;LMAN2;LMAN2L;MCFD2;CTAGE5;CNIH3
ER to Golgi Anterograde Transport	TRAPPC2L;SEC22C;TRAPPC6A;SEC22A;NSFA;TRAPPC3;YKT6;NAPAB;MCFD2
Membrane Trafficking	SNX9;TPD52;EXOC5;CLINT1;SH3D19;TBC1D8B;PICALMB;TRAPPC6BL;BET1
Metabolism of proteins	NEU4;EEF1A2;ZNF408;PFDN4;IGFALS;SAMM50;SLC30A5;ARL2;EXOC6
Post-translational protein modification	MUC12;A4GNT;ADAMTS1;NAPG;CTAGE5;B3GNT6;TRAPPC4;B3GNT8;EID3
Transport to the Golgi and subsequent modification	SEC22A;CNIH3;NAPB;TRAPPC3;MGAT4A;SEC16B;YKT6;TRAPPC2;CNIH

MCFD2 has several biochemical functions, for example, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MCFD2 itself. We selected most functions MCFD2 had, and list some proteins which have the same functions with MCFD2. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	CAPN2;PCDHB5;SLC25A24L;ANXA5;PCDHB12;SNCA;CDH8;MEGF6;ACTN2B

MCFD2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MCFD2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MCFD2.

LMAN1; RXRB; etcb_yerpe