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Official Full Name mediator complex subunit 17
Background The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors.
Synonyms MED17; mediator complex subunit 17; cofactor required for Sp1 transcriptional activation, subunit 6 (77kD) , cofactor required for Sp1 transcriptional activation, subunit 6, 77kDa , CRSP6; mediator of RNA polymerase II transcription subunit 17; CRSP77; D
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED17-1907H Recombinant Human MED17 Protein, GST-tagged Wheat Germ GST
    Human MED17-4391HCL Recombinant Human MED17 293 Cell Lysate HEK293 N/A
    Human MED17-663H Recombinant Human MED17 Mammalian Cell His
    Human MED17-804H Recombinant Human MED17, GST-tagged E.coli GST
    Mouse MED17-9689M Recombinant Mouse MED17 Protein Mammalian Cell His
    Rhesus Macaque MED17-2719R Recombinant Rhesus monkey MED17 Protein, His-tagged Mammalian Cell His
    Chicken MED17-1427C Recombinant Chicken MED17 Mammalian Cell His
    Zebrafish MED17-4783Z Recombinant Zebrafish MED17 Mammalian Cell His

    MED17 involved in several pathways and played different roles in them. We selected most pathways MED17 participated on our site, such as Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Thyroid hormone signaling pathway RXRA; HDAC1; PLCZ1; ATP1B4; STAT1; RXRB; PIK3CD; MED1; ATP1A4; SLC16A2

    MED17 has several biochemical functions, for example, RNA polymerase II transcription cofactor activity, ligand-dependent nuclear receptor transcription coactivator activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MED17 itself. We selected most functions MED17 had, and list some proteins which have the same functions with MED17. You can find most of the proteins on our site.

    Function Related Protein
    RNA polymerase II transcription cofactor activity NKX2-5; MED24; CNOT2; MED19B; MED11; THRAP3; MED30; RBM14; MED7; MED15
    ligand-dependent nuclear receptor transcription coactivator activity HMGA1; SRA1; NCOA3; PPRC1; SMARCD3; DCAF6; ATXN7L3; THRAP3; PUS1; PKN1
    protein binding HPGDS; CYB561; MCM4; UBE2E2; CTSC; TAF7L; SERPINI2; ATP5O; SLC7A1; AICDA
    receptor activity ICAM1; VAC14; PROCR; VMN1R50; NLGN2; NLGN3B; NPR2; FPR3; LDLR; THRAP3
    thyroid hormone receptor binding NR0B2; NSD1; NCOR1; MED17; MED13; TAF7; OASL; GTF2B; ZNHIT3; THRAP3
    transcription coactivator activity MED14; SAP130; NFATC4; TAF9; MNT; YAF2; MAGED1; SMARCA2; NEUROD1; KAT2A
    transcription cofactor activity BTG1; HES6; TRIP13; LDB1B; ZNF763; SLC26A3; NRG1; PHF21A; PSMC5; PIR
    ubiquitin protein ligase activity CDC34B; ARIH1; UBE2J2; PJA2; UBE2G1; PDZD4; UBR2; RAG1; MGRN1; MED20
    vitamin D receptor binding MED30; TAF11; RXRA; MED17; MED1; MED24; SNW1; MED14; MED4; TAF7

    MED17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED17 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED17.

    MED10; MED19; MED29; MED22; Med30

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