Home / Products / MED23


Official Full Name mediator complex subunit 23
Background The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.
Synonyms MED23; mediator complex subunit 23; cofactor required for Sp1 transcriptional activation, subunit 3, 130kDa , CRSP3; mediator of RNA polymerase II transcription subunit 23; CRSP130; DRIP130; Sur2; 130 kDa transcriptional co activator; 133 kDa transcriptional co activator; Activator recruited cofactor 130 kDa component; ARC 130; ARC130; Cofactor required for Sp1 transcriptional activation subunit 3 130kDa; Cofactor required for Sp1 transcriptional activation subunit 3 130kDa mediator; Cofactor required for Sp1 transcriptional activation subunit 3; CRSP 130; CRSP 130 kD subunit; CRSP 133; CRSP 3; CRSP complex subunit 3; CRSP133; CRSP3; CRSP3 protein; DKFZp434H0117; DRIP 130; KIAA1216; MED 23; SUR 2; Transcriptional co activator CRSP 130; Transcriptional co activator CRSP130; Vitamin D3 receptor interacting protein; Vitamin D3 receptor interacting protein complex 130 kDa component; 130 kDa transcriptional co-activator; 133 kDa transcriptional co-activator; activator-recruited cofactor 130 kDa component; MRT18; SUR-2
    • Species :
    • Human
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MED23-1906H Recombinant Human MED23 Protein, GST-tagged Wheat Germ GST
    Human MED23-809H Recombinant Human MED23, GST-tagged E.coli GST
    Rhesus Macaque MED23-2722R Recombinant Rhesus monkey MED23 Protein, His-tagged Mammalian Cell His
    Zebrafish MED23-1189Z Recombinant Zebrafish MED23 Mammalian Cell His

    MED23 involved in several pathways and played different roles in them. We selected most pathways MED23 participated on our site, such as Developmental Biology, Fatty acid, triacylglycerol, and ketone body metabolism, Gene Expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with MED23 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Developmental Biology SPAG9; ITGB3A; CFC1; PLXND1; CAP1; SCN3A; CLASP1; NRP2; FGF8B; DUSP5
    Fatty acid, triacylglycerol, and ketone body metabolism G0S2; ELOVL1A; MED23; SIN3B; MED9; SLC25A1; STIL; SREBF2; CYP4A11; MTF1
    Gene Expression NR5A1B; ELAC2; RPP14; TH1L; ZNF563; EEF1A1; ZNF192; XPOT; ZNF75A; ZNF750
    Generic Transcription Pathway ZNF37A; ZIM3; NR1I3; ZNF266; ZNF729; MED23; ZNF718; COX18; ZNF777; ZNF286A
    Metabolism NAALAD2; PROZA; UPP2; ACOT11A; PLD6; GNG13A; CYGB1; CHST14; LYPLA1; SLC25A15
    Metabolism of lipids and lipoproteins CERS5; GDF1; APOA5; Agmo; PPARGC1B; LMF1; ACOT8; CYP4F11; PPM1L; MED16
    PPARA activates gene expression MED18; PLIN2; MED15; MED31; GRHL1; SREBF2; MED8; MED19; MED10; MED23
    Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) GRHL1; MTF1; GLIPR1; PLIN2; MED21; MED6; MED26; G0S2; MED10; MED19

    MED23 has several biochemical functions, for example, protein binding, transcription coactivator activity, ubiquitin protein ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MED23 itself. We selected most functions MED23 had, and list some proteins which have the same functions with MED23. You can find most of the proteins on our site.

    Function Related Protein
    protein binding CLOCKB; RBM12B; COA6; EGR2; ARL2; MTMR7; DICER1; PKN1; TNF; DCX
    transcription coactivator activity MNT; TAF9; PRPF6; WNT3A; TUBB3; NPM1; SETD3; WWTR1; ABT1; TADA2A
    ubiquitin protein ligase activity PDZRN3B; RBX1; UHRF2; UBE2H; ITCH; ZNRF1; RABGEF1; UBE2KB; UBR1; ZNRF2

    MED23 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MED23 here. Most of them are supplied by our site. Hope this information will be useful for your research of MED23.

    MED10; CDK19; MED19; MED26; CDK8; MED14; MED25; MED16; rluC; pyrG

    Related Services & Products

    Apply For A Coupon

    $50 OFF Your First Purchase

    Apply For a Coupon

    Enter your email here to subscribe.

    creative biomart inc.

    Easy access to products and services you need from our library via powerful searching tools.

    Follow Us

    Copyright © 2021 Creative BioMart. All Rights Reserved. Terms and Conditions | Privacy Policy