MEF2C
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Official Full Name
myocyte enhancer factor 2C
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Overview
This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. -
Synonyms
MEF2C; myocyte enhancer factor 2C; myocyte-specific enhancer factor 2C; MADS box transcription enhancer factor 2, polypeptide C; C5DELq14.3; DEL5q14.3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rhesus Macaque
- HEK293
- HEK293T
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- N/A
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
MEF2C involved in several pathways and played different roles in them. We selected most pathways MEF2C participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, Oxytocin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MEF2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| MAPK signaling pathway | FGF8;CACNG7;PTPN7;MAPKAPK5;MAP2K7;NFKB2;RAC2;Casp3;NFKB1 |
| cGMP-PKG signaling pathway | ATP2B4;CALML3;GTF2IRD1;PDE5A;PLCB1;BNP;ROCK2;ATP1A3;SLC25A31 |
| Oxytocin signaling pathway | PIK3R2;ROCK1;MAPK1;KRAS;RHOA;PRKAB1;CCND1;RCAN1;GNAI3 |
| Transcriptional misregulation in cancer | MEN1;FUT8;CCNT1;PROM1;PTK2;BCL6;CLSTN2;ETV5;HIST1H3H |
MEF2C has several biochemical functions, for example, AT DNA binding, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MEF2C itself. We selected most functions MEF2C had, and list some proteins which have the same functions with MEF2C. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| AT DNA binding | HMGA2;CRIP1;HMGA1;POU3F4;MEF2C |
| DNA binding | ANO9A;MCM2;TCEB3B;ZNF668;ZNF8;ZNF560;MNX2B;ZNF76;HOXD3A |
| RNA polymerase II regulatory region sequence-specific DNA binding | PAX9;SP5;ZNF583;ATF5A;FOXF1;BCL6;SP1;PRKCBP1L;ZNF773 |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FLI1A;SOX9A;FOXS1;FOXD2;ERF;SP1;FOXO3A;ATF4;FOXG1C |
| activating transcription factor binding | MEF2D;DGKQ;EP300;ZFP516;RELA;HDAC1;ATOH8;TAF9;GATA4 |
| chromatin binding | REL;UXT;PARP1;SIX1;CITED2;KAT2A;NCOA5;GATA2A;POLG |
| core promoter proximal region sequence-specific DNA binding | DMRT2B;SP3A;CXXC1;DMRTA1;CREBBP;DMRT3;MIXL1;MEF2C;DMRTC1B |
| miRNA binding | PNPT1;AGO2;EIF2C3;AGO1;LIN28A;MEF2C;TARBP2;DICER1;RBM4 |
| protein binding | DHRS1;AVPR1A;ROS1;OBFC1;MOCS3;MAP3K3;EFNB2;APIP;TIFA |
| protein heterodimerization activity | ADRA2C;MYO5A;GABRR1;ALX4;H2AFY;MPP7;RBP4;ADIPOR1;HIST1H4H |
| transcription factor activity, RNA polymerase II core promoter sequence-specific | MEF2C;NKX3;TFAP2B;HEY2;MAX;HEY1;SMAD3;HEYL;PAX7 |
| transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding | RELA;AHR;SOX10;HNF1B;SOX7;PDX1;POU4F1;POU3F3;FOXP3 |
| transcription factor activity, sequence-specific DNA binding | FOXD1;PBX1B;RARGB;ZFP628;FOXP3;NR5A1B;ASCL1B;MAFA;TFAM |
| transcription regulatory region DNA binding | LEF1;GLIS2;WNT1;ZNF821;PAX8;AHR;GATA3;SFPQ;RCOR1 |
| transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding | ONECUTL;SOX9;GLI3;ZFP639;POU4F1;SMAD2;MEIS3;NFAT5;SIX2 |
MEF2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MEF2C here. Most of them are supplied by our site. Hope this information will be useful for your research of MEF2C.
MYLK2; HDAC4; Hdac5; EP300; TFCP2; Mylk2; YWHAZ; SPTBN1; MAPK7; MAPK14; COPS5; EPAS1; PLA2G12A; HDAC9; HDAC7; HDAC5
Research Area
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