MEF2C

  • Official Full Name

    myocyte enhancer factor 2C

  • Overview

    This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe mental retardation, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described.
  • Synonyms

    MEF2C; myocyte enhancer factor 2C; myocyte-specific enhancer factor 2C; MADS box transcription enhancer factor 2, polypeptide C; C5DELq14.3; DEL5q14.3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rhesus Macaque
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MEF2C-29558TH Recombinant Human MEF2C Wheat Germ N/A 469 amino acids
Human MEF2C-4375HCL Recombinant Human MEF2C 293 Cell Lysate HEK293 N/A
Human MEF2C-1393H Recombinant Human MEF2C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MEF2C-811H Recombinant Human MEF2C Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MEF2C-1393H-B Recombinant Human MEF2C Protein Pre-coupled Magnetic Beads HEK293
Human MEF2C-4455H Recombinant Human MEF2C Protein, GST-tagged Wheat Germ GST
Human MEF2C-310HF Recombinant Full Length Human MEF2C Protein In Vitro Cell Free System 469 amino acids
Human MEF2C-671HFL Recombinant Full Length Human MEF2C Protein, C-Flag-tagged Mammalian cells Flag
Human MEF2C-6260HF Recombinant Full Length Human MEF2C Protein, GST-tagged In Vitro Cell Free System GST 469 amino acids
Mouse Mef2c-4026M Recombinant Mouse Mef2c Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque MEF2C-2730R Recombinant Rhesus monkey MEF2C Protein, His-tagged Mammalian Cell His
Rhesus Macaque MEF2C-2550R-B Recombinant Rhesus Macaque MEF2C Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque MEF2C-2550R Recombinant Rhesus Macaque MEF2C Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MEF2C involved in several pathways and played different roles in them. We selected most pathways MEF2C participated on our site, such as MAPK signaling pathway, cGMP-PKG signaling pathway, Oxytocin signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MEF2C were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayFGF8;CACNG7;PTPN7;MAPKAPK5;MAP2K7;NFKB2;RAC2;Casp3;NFKB1
cGMP-PKG signaling pathwayATP2B4;CALML3;GTF2IRD1;PDE5A;PLCB1;BNP;ROCK2;ATP1A3;SLC25A31
Oxytocin signaling pathwayPIK3R2;ROCK1;MAPK1;KRAS;RHOA;PRKAB1;CCND1;RCAN1;GNAI3
Transcriptional misregulation in cancerMEN1;FUT8;CCNT1;PROM1;PTK2;BCL6;CLSTN2;ETV5;HIST1H3H

MEF2C has several biochemical functions, for example, AT DNA binding, DNA binding, RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MEF2C itself. We selected most functions MEF2C had, and list some proteins which have the same functions with MEF2C. You can find most of the proteins on our site.

Function Related Protein
AT DNA bindingHMGA2;CRIP1;HMGA1;POU3F4;MEF2C
DNA bindingANO9A;MCM2;TCEB3B;ZNF668;ZNF8;ZNF560;MNX2B;ZNF76;HOXD3A
RNA polymerase II regulatory region sequence-specific DNA bindingPAX9;SP5;ZNF583;ATF5A;FOXF1;BCL6;SP1;PRKCBP1L;ZNF773
RNA polymerase II transcription factor activity, sequence-specific DNA bindingFLI1A;SOX9A;FOXS1;FOXD2;ERF;SP1;FOXO3A;ATF4;FOXG1C
activating transcription factor bindingMEF2D;DGKQ;EP300;ZFP516;RELA;HDAC1;ATOH8;TAF9;GATA4
chromatin bindingREL;UXT;PARP1;SIX1;CITED2;KAT2A;NCOA5;GATA2A;POLG
core promoter proximal region sequence-specific DNA bindingDMRT2B;SP3A;CXXC1;DMRTA1;CREBBP;DMRT3;MIXL1;MEF2C;DMRTC1B
miRNA bindingPNPT1;AGO2;EIF2C3;AGO1;LIN28A;MEF2C;TARBP2;DICER1;RBM4
protein bindingDHRS1;AVPR1A;ROS1;OBFC1;MOCS3;MAP3K3;EFNB2;APIP;TIFA
protein heterodimerization activityADRA2C;MYO5A;GABRR1;ALX4;H2AFY;MPP7;RBP4;ADIPOR1;HIST1H4H
transcription factor activity, RNA polymerase II core promoter sequence-specificMEF2C;NKX3;TFAP2B;HEY2;MAX;HEY1;SMAD3;HEYL;PAX7
transcription factor activity, RNA polymerase II distal enhancer sequence-specific bindingRELA;AHR;SOX10;HNF1B;SOX7;PDX1;POU4F1;POU3F3;FOXP3
transcription factor activity, sequence-specific DNA bindingFOXD1;PBX1B;RARGB;ZFP628;FOXP3;NR5A1B;ASCL1B;MAFA;TFAM
transcription regulatory region DNA bindingLEF1;GLIS2;WNT1;ZNF821;PAX8;AHR;GATA3;SFPQ;RCOR1
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific bindingONECUTL;SOX9;GLI3;ZFP639;POU4F1;SMAD2;MEIS3;NFAT5;SIX2

MEF2C has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MEF2C here. Most of them are supplied by our site. Hope this information will be useful for your research of MEF2C.

MYLK2; HDAC4; Hdac5; EP300; TFCP2; Mylk2; YWHAZ; SPTBN1; MAPK7; MAPK14; COPS5; EPAS1; PLA2G12A; HDAC9; HDAC7; HDAC5

Research Area

Related articles

Yu, ZS; Kong, JJ; et al. Islet-1 May Function as an Assistant Factor for Histone Acetylation and Regulation of Cardiac Development-Related Transcription Factor Mef2c Expression. PLOS ONE 8:-(2013).
Madonna, R; Wu, DL; et al. Myocardin-A enhances expression of promyogenic genes without depressing telomerase activity in adipose tissue-derived mesenchymal stem cells. INTERNATIONAL JOURNAL OF CARDIOLOGY 167:2912-2921(2013).
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