Recombinant Mouse Mef2c Protein, Myc/DDK-tagged

• Cat.No.: Mef2c-4026M
• Product Overview: Purified recombinant protein of mouse full-length myocyte enhancer factor 2C (cDNA clone MGC:25468 IMAGE:4481227), complete cds, with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. May also be involved in neurogenesis and in the development of cortical architecture. Isoforms that lack the repressor domain are more active than isoform 1. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells.
• Molecular Mass: 48 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mef2c myocyte enhancer factor 2C [ Mus musculus (house mouse) ]
• Official Symbol: Mef2c
• Synonyms: Mef2c; myocyte enhancer factor 2C; Mef2; AV011172; 5430401D19Rik; 9930028G15Rik; myocyte-specific enhancer factor 2C
• Gene ID: 17260
• mRNA Refseq: NM_025282
• Protein Refseq: NP_079558
• UniProt ID: Q8CFN5