Recombinant Pig MMP1 Protein, His-tagged

• Cat.No.: MMP1-1116P
• Product Overview: Recombinant Pig MMP1 Protein (Phe100-Asn469) with His tag was expressed in E. coli.

Specification

• Description: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This secreted protease breaks down the interstitial collagens, including types I, II, and III. The gene is part of a cluster of MMP genes on chromosome 11. Mutations in this gene are associated with chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.
• Source: E. coli
• Species: Pig
• Tag: His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 42.6 kDa; Accurate Molecular Mass: 46 kDa
• Protein length: Phe100-Asn469
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in PBS or others.

Gene Information

• Gene Name: MMP1 matrix metallopeptidase 1 (interstitial collagenase) [ Sus scrofa ]
• Official Symbol: MMP1
• Synonyms: MMP1; matrix metallopeptidase 1 (interstitial collagenase); interstitial collagenase; MMP-1; matrix metalloproteinase-1; matrix metalloproteinase 1 (type I collagenase); Mmp1a
• Gene ID: 397320
• mRNA Refseq: NM_001166229
• Protein Refseq: NP_001159701
• UniProt ID: P21692

Reviews

08/26/2021

The manufacturer can offer technical support and expertise to guide researchers through the experimental process.

11/09/2020

The manufacturer can play a vital role in supporting and optimizing the research process.

07/20/2020

This guarantees that the protein is reliable, consistent, and suitable for experiments, reducing variability and enhancing the reproducibility of findings.

Q&As

How does MMP1 relate to wound healing?

MMP1 is involved in the remodeling of tissue during wound healing by facilitating the breakdown of damaged extracellular matrix components.

Are there therapeutic implications of targeting MMP1 in cancer treatment?

Inhibiting MMP1 activity is being explored as a potential therapeutic strategy to impede cancer progression and metastasis.

How does MMP1 contribute to tissue remodeling?

MMP1 plays a key role in tissue remodeling by degrading collagen, a major component of the extracellular matrix, which is essential for processes like wound healing.

In what diseases is MMP1 overexpressed?

MMP1 overexpression is associated with various diseases, including rheumatoid arthritis, atherosclerosis, and certain types of cancer.

Can MMP1 be a biomarker for prognosis in cancer patients?

High MMP1 levels have been correlated with poor prognosis in certain cancer types, making it a potential biomarker for predicting disease outcomes.