Recombinant Human MMP1 Protein, GST-tagged

• Cat.No.: MMP1-5413H
• Product Overview: Human MMP1 full-length ORF ( NP_002412.1, 1 a.a. - 469 a.a.) recombinant protein with GST-tag at N-terminal.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq
• Source: Wheat Germ
• Species: Human
• Tag: GST
• Molecular Mass: 80.4 kDa
• AA Sequence: MHSFPPLLLLLFWGVVSHSFPATLE TQEQDVDLVQKYLEKYYNLKNDGRQ VEKRRNSGPVVEKLKQMQEFFGLKV TGKPDAETLKVMKQPRCGVPDVAQF VLTEGNPRWEQTHLTYRIENYTPDL PRADVDHAIEKAFQLWSNVTPLTFT KVSEGQADIMISFVRGDHRDNSPFD GPGGNLAHAFQPGPGIGGDAHFDED ERWTNNFREYNLHRVAAHELGHSLG LSHSTDIGALMYPSYTFSGDVQLAQ DDIDGIQAIYGRSQNPVQPIGPQTP KACDSKLTFDAITTIRGEVMFFKDR FYMRTNPFYPEVELNFISVFWPQLP NGLEAAYEFADRDEVRFFKGNKYWA VQGQNVLHGYPKDIYSSFGFPRTVK HIDAALSEENTGKTYFFVANKYWRY DEYKRSMDPGYPKMIAHDFPGIGHK VDAVFMKDGFFYFFHGTRQYKFDPK TKRILTLQKANSWFNCRKN
• Applications: Enzyme-linked Immunoabsorbent Assay
  Western Blot (Recombinant protein)
  Antibody Production
  Protein Array
• Notes: Best use within three months from the date of receipt of this protein.
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.
• Storage Buffer: 50 mM Tris-HCI, 10 mM reduced Glutathione, pH=8.0 in the elution buffer.

Gene Information

• Gene Name: MMP1 matrix metallopeptidase 1 (interstitial collagenase) [ Homo sapiens ]
• Official Symbol: MMP1
• Synonyms: MMP1; matrix metallopeptidase 1 (interstitial collagenase); CLG, matrix metalloproteinase 1 (interstitial collagenase); interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1; CLG; CLGN
• Gene ID: 4312
• mRNA Refseq: NM_001145938
• Protein Refseq: NP_001139410
• MIM: 120353
• UniProt ID: P03956

Reviews

08/26/2021

The manufacturer can offer technical support and expertise to guide researchers through the experimental process.

11/09/2020

The manufacturer can play a vital role in supporting and optimizing the research process.

07/20/2020

This guarantees that the protein is reliable, consistent, and suitable for experiments, reducing variability and enhancing the reproducibility of findings.

Q&As

How does MMP1 relate to wound healing?

MMP1 is involved in the remodeling of tissue during wound healing by facilitating the breakdown of damaged extracellular matrix components.

Are there therapeutic implications of targeting MMP1 in cancer treatment?

Inhibiting MMP1 activity is being explored as a potential therapeutic strategy to impede cancer progression and metastasis.

How does MMP1 contribute to tissue remodeling?

MMP1 plays a key role in tissue remodeling by degrading collagen, a major component of the extracellular matrix, which is essential for processes like wound healing.

In what diseases is MMP1 overexpressed?

MMP1 overexpression is associated with various diseases, including rheumatoid arthritis, atherosclerosis, and certain types of cancer.

Can MMP1 be a biomarker for prognosis in cancer patients?

High MMP1 levels have been correlated with poor prognosis in certain cancer types, making it a potential biomarker for predicting disease outcomes.