Active Recombinant Human MMP1 Protein
Cat.No. : | MMP1-5412H |
Product Overview : | Human MMP1 (P03956) partial recombinant protein expressed in Escherichia coli. |
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Description : | Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq |
Source : | E. coli |
Species : | Human |
Form : | Lyophilized |
Bio-activity : | The protein is biologically active as determined by MMP-1 activity assay. |
Molecular Mass : | 19.9 kDa |
Endotoxin : | < 0.1 ng/μg |
Purity : | >= 95% by SDS-PAGE and HPLC |
Applications : | Functional Study SDS-PAGE |
Storage : | Store at -20 centigrade on dry atmosphere. After reconstitution with sterilized PBS, store at -20 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | No additive |
Tag : | Non |
Gene Name : | MMP1 matrix metallopeptidase 1 (interstitial collagenase) [ Homo sapiens ] |
Official Symbol : | MMP1 |
Synonyms : | MMP1; matrix metallopeptidase 1 (interstitial collagenase); CLG, matrix metalloproteinase 1 (interstitial collagenase); interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1; CLG; CLGN; |
Gene ID : | 4312 |
mRNA Refseq : | NM_001145938 |
Protein Refseq : | NP_001139410 |
MIM : | 120353 |
UniProt ID : | P03956 |
Products Types
◆ Recombinant Protein | ||
MMP1-2535H | Recombinant Human MMP1 protein(111-290 aa), N-MBP & C-His-tagged | +Inquiry |
MMP1-799H | Recombinant Human MMP1 Protein, His-tagged | +Inquiry |
MMP1-1115R | Recombinant Rabbit MMP1 Protein, His-tagged | +Inquiry |
MMP1-2536H | Recombinant Human MMP1 protein(20-469 aa), N-MBP & C-His-tagged | +Inquiry |
MMP1-4560H | Active Recombinant Human MMP1 protein(Met1-Asn469), His-tagged | +Inquiry |
◆ Native Protein | ||
MMP1-45H | Native Human MMP-1 | +Inquiry |
◆ Lysates | ||
MMP1-2884HCL | Recombinant Human MMP1 cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Customer Reviews (3)
Write a reviewThe manufacturer can offer technical support and expertise to guide researchers through the experimental process.
The manufacturer can play a vital role in supporting and optimizing the research process.
This guarantees that the protein is reliable, consistent, and suitable for experiments, reducing variability and enhancing the reproducibility of findings.
Q&As (5)
Ask a questionMMP1 is involved in the remodeling of tissue during wound healing by facilitating the breakdown of damaged extracellular matrix components.
Inhibiting MMP1 activity is being explored as a potential therapeutic strategy to impede cancer progression and metastasis.
MMP1 plays a key role in tissue remodeling by degrading collagen, a major component of the extracellular matrix, which is essential for processes like wound healing.
MMP1 overexpression is associated with various diseases, including rheumatoid arthritis, atherosclerosis, and certain types of cancer.
High MMP1 levels have been correlated with poor prognosis in certain cancer types, making it a potential biomarker for predicting disease outcomes.
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